Neural responses to kills/deaths in real MOBA games are associated with addiction-related psychological traits and subjective pleasant/unpleasant experiences.

Background And Aims: Players of Multiplayer Online Battle Arena (MOBA) games are at a heightened risk of developing Internet Gaming Disorder (IGD). We aimed to investigate the neural responses triggered by kills and deaths during real MOBA gameplay and explore their association with addiction-related psychological traits and subjective pleasant or unpleasant experiences.

Methods: We developed an experimental protocol to capture moments of kills and deaths during real MOBA gameplay.

Iterative Synthesis of Intrinsically Disordered Protein Mimics.

Artificial intrinsically disordered proteins (IDPs) are often biosynthesized in cells by repeating low-complexity sequences derived from native IDPs through rational engineering. Herein we report the chemical synthesis of stereocontrolled linear and cyclic IDP mimics with up to 640 amino acids (∼52 kDa) via an iterative exponential growth (IEG) strategy. Following a known sequence originating from the disordered region of natural tropoelastin, linear elastin-like polypeptides (ELPs) were synthesized by conjugating monomeric pentapeptides via IEG, which transferred the sequence and chiral features of pentapeptides to the resultant polypeptides, thereby achieving robust control of their molecular weights and stereochemistry.

Stereocomplexation-Promoted Alternating Supramolecular Copolymerization of Peptide-(Lactic Acid) Conjugates.

Spontaneous association of multiple components into coassemblies significantly amplifies the complexity of supramolecular systems. Owing to varied noncovalent interactions, the precise regulation of the copolymerization pathway, molecular arrangement, and assembled morphology remains a huge challenge. Here, we report an intriguing system as the first example of using complementary stereocomplexation between enantiomeric (lactic acid)s (LAs) to govern the supramolecular copolymerization behavior of a series of amphiphilic peptide conjugates.

Cumulative dose assessment with transformer-based deformable image registration addition for cervical cancer patients.

Purpose: Based on the combination mode of internal and external radiotherapy for cervical cancer, this study aimed to investigate an accurate transformer-based deformable image registration (DIR) method for cumulative dose assessment.

Methods And Materials: According to a retrospective analysis conducted on 180 patients with cervical cancer who underwent intracavitary brachytherapy (ICBT) and external beam radiation therapy (EBRT), this study proposed a mix-transformer structure-based deformable image registration (MTDIR) network for registering CT scans of ICBT and EBRT, followed by dose accumulation and assessment. The mean dice similarity coefficient (DSC) and Hausdorff distance (HD) of the rectum and bladder were computed to compare the performance of MTDIR with that of the state-of-the-art VoxelMorph method and the DIR method provided by velocity.

EEG dataset from playing Multiplayer Online Battle Arena games in natural settings.

Mobile Multiplayer Online Battle Arena (MOBA) games have emerged as one of the most popular gaming genres, yet the underlying neurophysiological mechanisms contributing to their addictive potential remain unclear. In this study, 23 participants played six real matches of Honor of Kings while synchronized 64-channel EEG recordings were conducted. We provide EEG data collected during gameplay, alongside corresponding video recordings.

Atomistic mechanisms of superlubricity in carbon nanotube heterostructures under linear elastic deformation.

Heterostructures have been introduced to achieve superior performance by assembling low-dimensional van der Waals materials. However, the friction properties of nanohybrids composed of one-dimensional (1D) nanotubes and two-dimensional (2D) materials remain challenging to detect experimentally. Herein, we employ atomic simulations to investigate the relationship between friction and deformation in a sandwich structure, where a single-walled carbon nanotube (SWCNT) is encapsulated between graphene layers.

Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer.

Targeted therapies for advanced microsatellite stable (MSS) subtype colorectal cancer (MSS-CRC) remain a clinical challenge. Here, we show that death receptor 5 (DR5) is elevated in both MSS and microsatellite instability-high (MSI-H) colorectal cancer (CRC) cohorts, highlighting its potential as a clinical target. Oba01, a clinical-stage DR5-targeting antibody-drug conjugate (ADC) delivering the microtubule-disrupting agent monomethyl auristatin E (MMAE), shows superior efficacy in CRC cell lines, patient-derived xenografts and their corresponding organoids, irrespective of MSS or MSI-H status.

Characterization of tannic acid-intravenous immunoglobulin (IVIG) protein complex and impact on drug-induced cytotoxicity in MDA-MB-468 breast cancer cells.

In this study, we investigated the molecular interaction between intravenous immunoglobulin (IVIG) and tannic acid (TA), a natural polyphenol, to assess the potential impact of this interaction on cellular responses relevant to cancer. Binding analysis revealed that the IVIG-TA complex forms through a single binding site on the protein with lgK = 3.08-4.

Inversed Benzene/Cyclohexene/Cyclohexane Adsorption Selectivities for One-Step Purification of Cyclohexene and Beyond.

Separation of benzene/cyclohexene/cyclohexane (Bz/Cye/Cya) mixtures, especially purification of Cye, is crucial but challenging in the petrochemical industry. Here, we report two new metal-organic frameworks with opposite adsorption selectivities for on-demand separation/purification of Bz/Cye/Cya mixtures. Although they possess similar frameworks and pore structures, their pore surfaces are functionalized by hydrophobic ethyl and hydrophilic hydroxymethyl groups, which interact conversely with Bz/Cye/Cya, giving a record-high Bz selectivity (129) and the first example of Cya/Cye/Bz selectivity (18.

Identification and characterization of chiral vitamin C using ion mobility and theoretical calculation.

Vitamin C (L-( +)-ascorbic acid, L-AA) is an essential micronutrient. Its diastereoisomer, D-(-)-isoascorbic acid (D-IAA), is only 5% as active as L-AA. Therefore, it is crucial to identify and characterize the diastereoisomers of ascorbic acid.

Introducing halogen-bonded gates into zeolitic frameworks for efficient benzene/cyclohexene/cyclohexane separation.

The separation of C cyclic hydrocarbons (benzene, cyclohexene, and cyclohexane) is one of the most challenging chemical processes in the petrochemical industry. Herein, we design and synthesize a new SOD-topology metal azolate framework (MAF) with aperture gating behaviour controlled by C-Br⋯N halogen bonds, which exhibits distinct temperature- and guest-dependent adsorption behaviours for benzene/cyclohexene/cyclohexane. More importantly, the MAF enables the efficient purification of benzene from its binary and ternary mixtures (selectivity up to 113 ± 2; purity up to 98% +), which is the highest record for benzene/cyclohexane/cyclohexene separation to date.

Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter.

Background: In China, 80% of Hepatocellular Carcinoma (HCC) is associated with cirrhosis. Portal hypertension, the most common outcome of cirrhosis progression, has a high incidence. Platelet count/spleen diameter ratio (PSL) with a cut-off value of 909 can predict the presence of esophagogastric varices and thus portal hypertension, which is also an independent risk factor for early recurrence and late recurrence of hepatocellular carcinoma after resection.

Identification of significant single-nucleotide polymorphisms associated with breast cancer recurrence and metastasis using GWAS.

Background: Identification of risk genes and loci associated with the recurrence and metastasis of breast cancer (BC) is of utmost importance. Genome-wide association studies (GWASs) represent valuable tools for identifying the disease risk associated with a given single-nucleotide polymorphism (SNP); they offer significant insights into the disease progression mechanism by analyzing SNP information of the entire genome. Though GWAS has already identified several genetic susceptibility SNPs for BC, their significance in the recurrence and metastasis of this cancer remains unclear.

The Role of Potato Glycoside Alkaloids Mediated Oxidative Stress in Inducing Apoptosis of Wolfberry Root Rot Pathogen Fungi.

Wolfberry () is a vital economic tree species in northwest China, but root rot caused by occurs frequently, which seriously endangers the quality and yield of wolfberry. In this study, potato glycoside alkaloids (PGAs), a plant-derived active substance, were used as materials to explore its inhibitory effect on . By analyzing the changes of reactive oxygen species (ROS) level, antioxidant capacity, and apoptosis, the role of PGAs-mediated oxidative stress in inducing apoptosis of was revealed.

Combination therapy strategies against multidrug resistant bacteria in vitro and in vivo.

Exploring effective combination antibacterial therapies has become a research focus. This study selected seven common antibiotics to perform a series of tests on different Gram-negative bacteria isolated from clinical samples of chronic obstructive pulmonary disease patients. More than 70% of the strains exhibited multidrug resistance but remained sensitive to polymyxin B.

An improved cancer diagnosis algorithm for protein mass spectrometry based on PCA and a one-dimensional neural network combining ResNet and SENet.

Cancer is one of the most serious health problems worldwide. Because cancer has no specific symptoms in its early stages, it is often not diagnosed until it is in advanced stages, reducing the likelihood of successful treatment. Therefore, early diagnosis of cancer is a formidable challenge.

Elevated non-HDL-C to HDL-C ratio as a marker for NAFLD and liver fibrosis risk: a cross-sectional analysis.

Background: Dyslipidemia is a known independent risk factor for Nonalcoholic fatty liver disease (NAFLD). However, the relationship between NAFLD and the serum non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio remains unclear. This study examined the association between the non-HDL-C to HDL-C ratio and NAFLD prevalence, including liver steatosis and fibrosis levels in the population.

Design and Applications of Supramolecular Peptide Hydrogel as Artificial Extracellular Matrix.

Supramolecular peptide hydrogels (SPHs) consist of peptides containing hydrogelators and functional epitopes, which can first self-assemble into nanofibers and then physically entangle together to form dynamic three-dimensional networks. Their porous structures, excellent bioactivity, and high dynamicity, similar to an extracellular matrix (ECM), have great potential in artificial ECM. The properties of the hydrogel are largely dependent on peptides.

Association between RC/HDL-C ratio and risk of non-alcoholic fatty liver disease in the United States.

Background: The occurrence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. The link between serum remnant cholesterol (RC) to high-density lipoprotein cholesterol (HDL-C) ratio and NAFLD remains unclear. Therefore, we sought to clarify the relationship between the RC/HDL-C ratio and the NAFLD.

Stabilizing hexagonally close-packed phase in single-component block copolymers through rational symmetry breaking.

Despite being predicted to be a thermodynamically equilibrium structure, the absence of direct experimental evidence of hexagonally close-packed spherical phase in single-component block copolymers raises uncomfortable concerns regarding the existing fundamental phase principles. This work presents a robust approach to regulate the phase behavior of linear block copolymers by deliberately breaking molecular symmetry, and the hexagonally close-packed lattice is captured in a rigorous single-component system. A collection of discrete ABA triblock copolymers is designed and prepared through an iterative growth method.