Programmed death 1, ligand 1 and 2 correlated genes and their association with mutation, immune infiltration and clinical outcomes of hepatocellular carcinoma.

Background: The exact regulation network of programmed death 1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) signaling in immune escape is largely unknown. We aimed to describe the gene expression profiles related to PD-1 as well as its ligands PD-L1 and PD-L2, thus deciphering their possible biological processes in hepatocellular carcinoma (HCC).

Aim: To find the possible mechanism of function of PD-1, PD-L1, and PD-L2 in HCC.

Clinical Utility of SNP Array Analysis in Prenatal Diagnosis: A Cohort Study of 5000 Pregnancies.

Background: Single nucleotide polymorphism array (SNP-array) has been introduced for prenatal diagnosis. We aimed to evaluate the clinical value of SNP-array in the diagnosis of fetal chromosomal anomalies.

Methods: A retrospective study was conducted on 5000 cases tested by SNP-array, and the results of 4022 cases analyzed by both karyotyping and SNP-array were compared.

New and little-known species of Linnaeus (Diptera, Tipulidae) from Laos, with a new synonym.

Only seven species of the genus Linnaeus were previously known to occur in Laos. Here one new species is added to the fauna of Laos, Tipula (Nippotipula) champasakensis (unplaced) Alexander, 1936 is designated as a synonym of (unplaced) Walker, 1848, A key to species of the genus from Laos is presented.

Undifferentiated embryonal sarcoma of the liver: Clinical characteristics and outcomes.

Background: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver malignancy originating from primary mesenchymal tissue. The clinical manifestations, laboratory tests, and imaging examinations of the disease lack specificity and the preoperative misdiagnosis rate is high. The overall prognosis is poor and survival rate is low.

Ice-interface assisted large-scale preparation of polypyrrole/graphene oxide films for all-solid-state supercapacitors.

In this paper, large-scale, self-standing polypyrrole/graphene oxide (PPy/GO) nanocomposite films were prepared by an environmentally friendly and easy-to-operate confined polymerization method, and were also assembled as electrode materials for symmetric all-solid-state supercapacitors. In this paper, large-scale, self-standing polypyrrole/graphene oxide (PPy/GO) nanocomposite films were prepared by an environmentally friendly and easy-to-operate confined polymerization method, and were also assembled as electrode materials for symmetric all-solid-state supercapacitors. The morphology, chemical structure and electrochemical property were characterized by field emission scanning electron microscope (FESEM), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectroscopy (EIS), respectively.

Pressure-Regulated Dynamic Stereochemical Role of Lone-Pair Electrons in Layered BiOS.

Lone-pair electrons (LPEs) s in subvalent 14 and 15 groups lead to highly anharmonic lattice and strong distortion polarization, which are responsible for the groups' outstanding thermoelectric and optoelectronic properties. However, their dynamic stereochemical role in structural and physical properties is still unclear. Here, by introducing pressure to tune the behavior of LPEs, we systematically investigate the lone-pair stereochemical role in a BiOS.

Catalysis-based specific detection and inhibition of tyrosinase and their application.

Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome, and plays a key role in the pigmentation of hair and skin. The abnormal expression or activation of tyrosinase is associated with several diseases such as albinism, vitiligo, melanoma and Parkinson disease. Excessive deposition of melanin could cause diseases such as freckles and brown spots in the human body, and it is also closely related to browning of fruits and vegetables and insect molting.

Meigen (Diptera, Tipulidae) from Xizang Autonomous Region, China.

Eight species of the genus were previously known to occur in Xizang Autonomous Region. Here, three species are added to the fauna of Xizang. Among them two species, and are described and illustrated as new to science, and one species, Alexander, 1935 is recorded from Xizang for the first time.

The effects of the primary health care providers' prescription behavior interventions to improve the rational use of antibiotics: a systematic review.

Background: Irrational antibiotics use in clinical prescription, especially in primary health care (PHC) is accelerating the spread of antibiotics resistance (ABR) around the world. It may be greatly useful to improve the rational use of antibiotics by effectively intervening providers' prescription behaviors in PHC. This study aimed to systematically review the interventions targeted to providers' prescription behaviors in PHC and its' effects on improving the rational use of antibiotics.

Two new species of Meigen, 1803 from Northwest China (Diptera, Limoniidae).

Two new species of Meigen, 1803, and are described and illustrated from Northwest China. The following five species are re-described and reported from China for the first time: (Schummel, 1829), (Schrank, 1781), (Meigen, 1818), (Schummel, 1829) and (Strobl, 1895). A key to adult males of from Northwest China is presented.

A new species of Sphaeronemoura (Plecoptera: Nemouridae) from Guangxi Zhuang Autonomous Region of southern China.

A new amphinemurine nemourid species, Sphaeronemoura acutispina sp. n. is reported from Guangxi Zhuang Autonomous Region of southern China and is compared to its most similar congener.

A new species of the Indonemoura fujianensis complex (Plecoptera: Nemouridae) from the Guangxi Zhuang Autonomous Region of southern China.

A new species of Nemouridae of the genus Indonemoura Baumann, Indonemoura maoershana sp. nov., is described from Maoershan National Natural Reserve in the Guangxi Zhuang Autonomous Region of southern China, and is recognized as member of the I.

Two new species of the Amphinemura sinensis group (Plecoptera: Nemouridae) from southern China.

Two new species of the genus Amphinemura in the sinensis species group, A. retusilobata sp. n.

A new species of Eucapnopsis (Plecoptera: Capniidae) from China.

A new species of Capniidae, Eucapnopsis yunnana sp. nov., is described and illustrated from Yunnan Province, southwestern China.

Five new species of the genus Noeetomima Enderlein (Diptera: Lauxaniidae) from China, with a key to world species.

Five species of Noeetomima Enderlein, 1937 from Southwest China are described as new to science: Noeetomima hongshanensis sp. nov., N.

A prospective multicentre external validation study of the Liverpool Peritonsillar abscess Score (LPS) with a no-examination COVID-19 modification.

Objectives: Our primary aim was to validate the Liverpool Peritonsillar abscess Score (LPS) externally in a new patient cohort. Our secondary aim was to modify the LPS in the light of the COVID-19 pandemic to produce a no-examination variant for use in this instance.

Design: Prospective multicentre external validation study.

Multiple omics analysis reveals that high fiber diets promote gluconeogenesis and inhibit glycolysis in muscle.

Background: Meat quality is a complex trait affected by genotypic and environmental factors. In a previous study, it was found that feedstuffs have various effects on the growth rate and meat quality of lambs. However, the underlying mechanisms are still not entirely clear.

Spatial distribution, source identification, and risk assessment of organochlorines in wild tilapia from Guangxi, South China.

Seventy-five wild tilapia samples from six rivers (ten sites) in Guangxi province were collected and analyzed for 53 organochlorine compounds. DDTs, endosulfan, and PCBs were the most dominant compounds found in this study. Tiandong County (TD) and Guigang City (GG) sites were found to be heavily contaminated with high levels of endosulfan (385-925 ng/g lw) and/or DDTs (20.

Formation of non-extractable residues as a potentially dominant process in the fate of PAHs in soil: Insights from a combined field and modeling study on the eastern Tibetan Plateau.

Whereas non-extractable residue (NER) formation is recognized as an important process affecting the ecological risk of organic contaminants in soils, it is commonly neglected in regional-scale multi-media models assessing chemical environmental fate and risk. We used a combined field and modeling study to elucidate the relative importance of NER formation to the reduction in available organic contaminants compared with fate processes commonly considered in risk assessment models (volatilization, leaching, and biodegradation). Specifically, four polycyclic aromatic hydrocarbons (PAHs), i.

Editorial: serum HBV RNA biphasic decline in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.

This article is linked to Liu et al papers. To view these articles, visit https://doi.org/10.

Efficacy and safety of tenofovir alafenamide fumarate for preventing mother-to-child transmission of hepatitis B virus: a national cohort study.

Background: Data on tenofovir alafenamide fumarate (TAF) for preventing mother-to-child transmission of hepatitis B virus (HBV) are lacking.

Aims: To investigate the efficacy and safety of TAF therapy for preventing hepatitis B mother-to-child transmission.

Methods: Mothers with chronic HBV infection, positive for hepatitis B e-antigen and with HBV DNA >200 000 IU/mL received TAF for preventing mother-to-child transmission were enrolled retrospectively from multiple centres with data collection on mother-infant dyads up to postpartum week 24-28.

Controlled attenuation parameter value-based diagnostic algorithm improves the accuracy of liver stiffness measurement in chronic hepatitis B patients.

Liver stiffness measurement (LSM) frequently overestimates the severity of liver fibrosis because of steatosis. However, the impact of the controlled attenuation parameter (CAP) on liver stiffness cutoff values remains unknown; CAP was used to quantify and diagnose the severity of hepatic steatosis. The study was conducted to determine the effect of CAP on liver stiffness cutoff values in chronic hepatitis B (CHB) patients.

Four new species of the subfamily Homoneurinae (Diptera, Lauxaniidae) from southwestern China.

Four species of Homoneurinae from southwestern China are described as new to science: , , , and An updated key to the species of the genera , , and recorded in China is presented.

IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO -induced liver fibrosis.

Liver fibrosis is a severe health problem worldwide, and it is characterized by the activation of hepatic stellate cells (HSCs) and excessive deposition of collagen. Prolonged arsenic exposure can induce HSCs activation and liver fibrosis. In the present study, the results showed that chronic NaAsO ingestion could result in liver fibrosis and oxidative stress in Sprague-Dawley rats, along with representative collagen deposition and HSCs activation.