Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway.

Diabetic cardiomyopathy (DCM) is a specific type of cardiac dysfunction in diabetic patients, currently has no effective therapies. The TLR4 signaling pathway, activated through MyD88 and NF-κB, plays a critical role in DCM by triggering the release of pro-inflammatory cytokines and promoting pyroptosis through NLRP3 inflammasomes. Additionally, the TGF-β/Smad signaling pathway drives myocardial fibrosis, further compromising cardiac function.

Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution.

Nonradiative photothermal (PT) and photoacoustic (PA) processes have found widespread applications in imaging, stimulation, and therapy. Mapping the generation and propagation of PA and PT waves with high resolution is important to elucidate the interaction between nonradiative fields and biological systems. To this end, we introduce spatial-offset pump-probe imaging (SOPPI).

VIRMA utilizes m6A-IGF2BP2 to mediate NDRG1, thereby increasing sensitivity to iron-chelating agents and subsequently inhibiting the proliferation and metastasis of oral squamous cell carcinoma.

N6-methyladenosine (m6A) methylation, a key epigenetic modification, plays a critical role in regulating cellular processes such as proliferation, differentiation, apoptosis, and metastasis. VIR-like m6A methyltransferase associated (VIRMA), a major driver of m6A methylation and the largest known component of the m6A machinery, is essential for m6A-dependent biological functions. However, its precise role in oral squamous cell carcinoma (OSCC) progression remains poorly understood.

Screening drought tolerance in potato germplasm resources in the northwestern region of China.

Background: Drought is one of the major factors affecting the growth and development of potatoes. Screening drought-tolerant potato germplasm is of great significance for drought tolerance research and the utilization of drought-tolerant germplasm resources.

Results: In this study, a two-year field evaluation of drought tolerance was conducted on 31 potato germplasm resources from 2023 to 2024.

Cu-doped ZnO nanoparticles and its application for the photocatalytic degradation of Rhodamine B.

Rhodamine B (RhB), a dye with high environmental pollution risks, necessitates effective degradation strategies for environmental protection. Photocatalytic degradation technology offers a viable solution to mitigate such pollution, with ZnO being extensively utilized in dye degradation due to its excellent ultraviolet (UV) photocatalytic performance. In this study, Cu-doped ZnO nanoparticles were successfully synthesized via a facile method.

Global Epidemiology of Early-Onset Digestive System Malignancy: A Systematic Analysis for the Global Burden of Disease Study 2021.

Background And Aim: The researches on the global burden of digestive system malignancy in young populations were limited. This study aimed to comprehensively investigate the burden of early-onset digestive system malignancy (often defined as cancers diagnosed below the age of 50) based on the Global Burden of Disease 2021.

Methods: Data of incidence, prevalence, deaths, disability-adjusted life years (DALYs), and risk factors for the five major early-onset digestive system malignancies, including early-onset esophageal cancer (EOEC), early-onset gastric cancer (EOGC), early-onset liver cancer (EOLC), early-onset pancreatic cancer (EOPC), and early-onset colorectal cancer (EOCRC), were extracted from GBD 2021.

A membrane-free electrochemical reactor for efficient oxygen removal via gravity-assisted product self-separation.

Although electrochemical technologies offer vast industrial prospects, broader adoption-particularly in consumer applications-remains constrained by high costs and limited component lifespans. Here, we present a gravity-assisted, membrane-free electrochemical oxygen (O) removal (EOR) reactor coupling oxygen reduction (ORR) and oxygen evolution (OER) reactions. Leveraging fluid mechanics insights, buoyant O bubbles ascend rapidly, achieving 95% product self-separation and eliminating the need for membranes or external circulation.

Effects of lactoferrin on high-fat and high-cholesterol diet-induced non-alcoholic fatty liver disease in mice.

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, representing a growing public health burden. While previous studies indicated that lactoferrin (LF) alleviates hepatic lipid accumulation, a hallmark of NAFLD, the mechanisms involved are still elusive. Male C57BL/6 J mice were randomly divided into the control (CON), high-fat, high-cholesterol diet containing cholate (HFCCD), and HFCCD+LF groups and treated for 8 weeks' intervention.

Sensitive detection of HO based on a MWCNTs/TiC nanocomposite-modified electrode.

In this work, MWCNTs/TiC nanocomposites were synthesized by a convenient method and characterized in terms of structure and properties by SEM, FT-IR, XPS and electrochemical methods. The electrochemical sensor developed with MWCNTs/TiC nanocomposites exhibits good electrochemical properties. The sensor demonstrates excellent electrocatalytic performance for HO and was used to detect the concentration of HO.

Targeting Lung Damage: Amniotic Mesenchymal Stem Cells Mitigate Lipopolysaccharide-Induced Acute Lung Injury via Multiple Signaling Pathways.

Acute lung injury (ALI) is a life-threatening condition triggered by pneumonia, viral infections, or physical trauma. It manifests clinically as progressive respiratory failure and refractory hypoxemia. Using a lipopolysaccharide (LPS)-induced acute lung injury mouse model, we demonstrated that amniotic mesenchymal stem cells (AMSCs) exhibit robust reparative and anti-inflammatory properties.

The Impact of Stigma of Loneliness on Psychological Distress in Older Adults: The Chain Mediating Effect.

Objective: Loneliness and psychological distress are serious challenges for older adults to cope with and factors threatening life quality and happiness during their remaining years. Older people's attitudes and evaluations towards loneliness potentially affect psychological distress. Therefore, the current study aimed to examine the relationship between the stigma of loneliness and the psychological distress of older adults, further exploring the mediating effect of distress disclosure and loneliness.

Catechin promotes endoplasmic reticulum stress-mediated gastric cancer cell apoptosis via NOX4-induced reactive oxygen species.

Catechin, a polyphenolic compound in various foods and beverages, shows strong anti-cancer effects against gastric cancer (GC) cells. This study explored the effect of catechin on GC cell apoptosis and endoplasmic reticulum (ER) stress. GC cells were treated with different catechin concentrations to assess effects on cell viability, LDH release, invasion, migration, apoptosis, intracellular calcium (Ca⁺), ER stress markers, and reactive oxygen species (ROS).

Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma.

The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumorigenesis is interesting. Macrophages can be present as M1 and M2 polarization that show anti-cancer and oncogenic activities, respectively.

Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating mediated endoplasmic reticulum stress.

Colorectal adenocarcinoma (COAD) is a significant cause of cancer-related mortality worldwide, necessitating the identification of novel therapeutic targets and treatments. This research aimed to investigate the role of ARL3 in COAD progression and to explore the effects of Piperine on ARL3 expression, cell proliferation, epithelial-mesenchymal transition (EMT), and endoplasmic reticulum (ER) stress. Bioinformatics analysis of The Cancer Genome Atlas (TCGA)-COAD, GSE39582, and GSE44861 datasets assessed ARL3 expression levels.

[Genetic analysis of two families with abnormal findings upon prenatal diagnosis].

Objective: To carry out genetic analysis on two families with carriers of small terminal translocations using karyotyping analysis and genomic copy number variation sequencing (CNV-seq).

Methods: Two couples undergoing prenatal diagnosis at the Tianjin Central Hospital of Obstetrics and Gynecology respectively on April 12, 2020 and December 17, 2021 were selected as the study subjects. With informed consent, amniotic fluid and peripheral blood samples were collected and subjected to conventional karyotyping and CNV-seq analysis for the detection of chromosomal microdeletion/duplications.

Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis.

Background: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can destroy normal liver function and architecture. miRNA's own regulation was involved in DNA methylation change.

Research Progress of Bioactive Components in spp.

The species in are a group of edible mushrooms with a long history of oral use in East Asia as a health-improvement method. They should be classified under the genus rather than mistakenly in or . The major components in this genus consist of polysaccharides, polyphenols, triterpenoids, and flavonoids, all of which exist in the fruiting bodies and mycelia.

Formulation of international standards of Chinese medicine technology: clinical practice guide of Chinese medicine for cough.

Objective: To formulate the first clinical practice guideline for the treatment of cough using Chinese medicine based on the grading of recommendations assessment, development, and evaluation (GRADE) systematic approach, including clinical evidence, evaluation of ancient literature, and expert consensus.

Methods: In the process of development, the regulation of "evidence-based, consensus-assisted, and empirical" was followed, and a comprehensive systematic approach of recommendation assessment, GRADE, evidence-based evaluation, expert consensus, and the Delphi method was used. In the process of guideline development, evidence-based evaluation of ancient literature was included for the first time, and clinical evidence was fully integrated with clinical expert consensus.

CD36: The Bridge between Lipids and Tumors.

It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells.

Cross‑talk between lymphangiogenesis and malignant melanoma cells: New opinions on tumour drainage and immunization (Review).

Malignant melanoma (MM) is a highly aggressive tumour that can easily metastasize through the lymphatic system at the early stages. Lymph node (LN) involvement and lymphatic vessel (LV) density (LVD) represent a harbinger of an adverse prognosis, indicating a strong link between the state of the lymphatic system and the advancement of MM. Permeable capillary lymphatic vessels are the optimal conduits for melanoma cell (MMC) invasion, and lymphatic endothelial cells (LECs) can also release a variety of chemokines that actively attract MMCs expressing chemokine ligands through a gradient orientation.

Automating the analysis of eye movement for different neurodegenerative disorders.

The clinical observation and assessment of extra-ocular movements is common practice in assessing neurodegenerative disorders but remains observer-dependent. In the present study, we propose an algorithm that can automatically identify saccades, fixation, smooth pursuit, and blinks using a non-invasive eye tracker. Subsequently, response-to-stimuli-derived interpretable features were elicited that objectively and quantitatively assess patient behaviors.

Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.

Our previous animal studies found that the preventive effects of lactoferrin (Lf) on alcoholic liver injury (ALI) are associated with nuclear factor E2-related factor 2 (Nrf2). To further explore the causality, experiments were performed using rat normal liver BRL-3A cells. Lf treatment reduced ethanol-induced death and apoptosis; meanwhile, Lf treatment alleviated excessive LDH release.