Multimodality Imaging of Left Coronary Artery Complete Occlusion With Thrombosis Secondary to Kawasaki Disease.

Giant coronary artery aneurysms caused by Kawasaki disease (KD) are rare but can result in substantial morbidity and mortality due to the risk of thrombosis, stenosis, and myocardial infarction. This was the first report of KD causing complete occlusion and thrombus formation of the entire left coronary artery.

Magnetic Nanoparticle-Assisted Multiplex RPA for Rapid Meat Authentication via Fluorescence Detection.

Meat adulteration with undeclared species remains a pervasive problem. We report a rapid, sensitive, and field-deployable assay-termed magnetic nanoparticle-assisted multiplex recombinase polymerase amplification (mRPA) with fluorescence detection for the simultaneous detection of horse and chicken components in meat. It integrates mRPA, streptavidin-coated core-shell FeO@SiO nanoparticles, and dual-labeled primers targeting ATP6-8 (horse) and CYTB (chicken) genes.

CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice.

Late-onset Tay-Sachs (LOTS) disease is a lysosomal storage disorder most commonly caused by a point mutation (c.805G>A) in the HEXA gene encoding the α subunit of the lysosomal enzyme β-hexosaminidase A. LOTS manifests as a range of gradually worsening neurological symptoms beginning in young adulthood.

Ethical Privacy Framework for Large Language Models in Smart Healthcare: A Comprehensive Evaluation and Protection Approach.

The increasing integration of large language models (LLMs) in healthcare systems has revolutionized medical service delivery while introducing privacy vulnerabilities that could compromise patient information. Traditional privacy-preserving approaches often degrade performance in healthcare applications. This paper presents HELP-ME, a framework for evaluating and protecting privacy in healthcare-oriented LLMs through a three-stage approach.

Development of a model combining CEUS LI-RADS and clinical features for predicting glypican-3 expression in hepatocellular carcinoma.

Objective: To establish a predictive model incorporating clinical features and contrast-enhanced ultrasound (CEUS) liver Imaging Reporting and Data System (LI-RADS) for predicting glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC).

Methods: A total of 142 HCC patients between January 2020 to June 2021 in our institution were retrospectively analyzed. All patients underwent CEUS before surgery, and the reference standard was immunohistochemical analysis of surgical specimen.

Left heart function and strain for predicting change in hemoglobin levels in pediatric kidney transplantation recipients.

Introduction: Anemia is prevalent after kidney transplantation (KTx) and is associated with reduced graft survival. The associations between temporal changes in hemoglobin (Hb) level in the early posttransplant period with left ventricular (LV) and atrial (LA) function and strain are unknown.

Methods: The study cohort included 71 successful pediatric KTx recipients between January 2021 and September 2022.

Robot-assisted puncture versus conservative treatment for severe brainstem hemorrhage: clinical outcomes comparison with experience of 138 cases in a single medical center.

Introduction: The application of robot-assisted surgical technology in treating brainstem hemorrhage has garnered increasing attention. Treatments such as stereotactic hematoma aspiration and neuroendoscopic surgery are becoming more prevalent in China. The aim of this study is to provide a detailed comparative analysis of the clinical effects of robot-assisted puncture technology versus traditional conservative treatment, offering a scientific basis for optimizing treatment plans and improving patient outcomes.

Exploration of Bioactive Umami Peptides from Wheat Gluten: Umami Mechanism, Antioxidant Activity, and Potential Disease Target Sites.

Umami peptides have the ability to enhance food flavours and have potential health benefits. The objective of this study was to conduct a comprehensive investigation into the umami intensity, taste mechanism, and antioxidant activity of six umami peptides derived from wheat gluten hydrolysates (WGHs) and fermented WGHs. The e-tongue analysis demonstrated that the peptides exhibited a direct proportionality in terms of umami value and concentration, and were capable of enhancing the umami of commercially available condiments.

A literature review of contacting force measurement methods for pedestrian crowds.

This article reviewed state-of-the-art achievements in pedestrian contacting force measurement as a hotspot survey closer to ground truth supporting pedestrian dynamics in mass-gathering environments. It analyzed different forces acting on pedestrian bodies, including normal external forces, self-driven forces, abnormal external forces, and pedestrian motion constraint forces from other obstacles, besides the crowding posture on the force distribution. This review covered main methodologies: sophisticated pressure sensors, modern technology for pedestrian motion-capturing systems, and advanced numerical simulations.

[The new progress and significance of new ultrasound technology in the diagnosis of azoospermia].

The diagnosis and treatment of azoospermia rely heavily on auxiliary ex-amination technology. Compared with CT and MRI, ultrasound has more practical value in the diagnosis of azoospermia.Currently, the main ultrasonic technologies are contrast-enhanced ultrasound, real-time ultrasound elastography and ultrasound tar-geted puncture.

Revolutionizing CO Electrolysis: Fluent Gas Transportation within Hydrophobic Porous CuO.

The success of electrochemical CO reduction at high current densities hinges on precise interfacial transportation and the local concentration of gaseous CO. However, the creation of efficient CO transportation channels remains an unexplored frontier. In this study, we design and synthesize hydrophobic porous CuO spheres with varying pore sizes to unveil the nanoporous channel's impact on gas transfer and triple-phase interfaces.

Salmonella manipulates macrophage migration via SteC-mediated myosin light chain activation to penetrate the gut-vascular barrier.

The intestinal pathogen Salmonella enterica rapidly enters the bloodstream after the invasion of intestinal epithelial cells, but how Salmonella breaks through the gut-vascular barrier is largely unknown. Here, we report that Salmonella enters the bloodstream through intestinal CX3CR1 macrophages during early infection. Mechanistically, Salmonella induces the migration/invasion properties of macrophages in a manner dependent on host cell actin and on the pathogen effector SteC.

Genome-Wide Identification of Callose Synthase Family Genes and Their Expression Analysis in Floral Bud Development and Hormonal Responses in .

Callose is an important polysaccharide composed of beta-1,3-glucans and is widely implicated in plant development and defense responses. Callose synthesis is mainly catalyzed by a family of callose synthases, also known as glucan synthase-like (GSL) enzymes. Despite the fact that GSL family genes were studied in a few plant species, their functional roles have not been fully understood in woody perennials.

Evoking C production from electrochemical CO reduction by the steric confinement effect of ordered porous CuO.

Selective conversion of carbon dioxide (CO) to multi-carbon products (CO-to-C) at high current densities is in essential demand for the practical application of the resultant valuable products, yet it remains challenging to conduct due to the lack of efficient electrocatalysts. Herein, three-dimensional ordered porous cuprous oxide cuboctahedra (3DOP CuO-CO) were designed and synthesized by a molecular fence-assisted hard templating approach. Capitalizing on the merits of interconnected and uniformly distributed pore channels, 3DOP CuO-CO exhibited outstanding electrochemical CO-to-C conversion, achieving faradaic efficiency and partial current density for C products of up to 81.

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.

GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ganglioside (GA1 glycolipid) in brain. This disease can present in varying degrees of severity, with the level of residual β-galactosidase activity primarily determining the clinical course.

Treatment of Ventriculitis and Meningitis After Neurosurgery Caused by Carbapenem-Resistant (CRE): A Challenging Topic.

Post-neurosurgical infection is a common complication of neurosurgery, and serious infection can threaten the life of patients. In recent years, the increase in multidrug-resistant bacteria, especially carbapenem-resistant (CRE), has proved fatal to patients. Although there are a few cases of CRE meningitis and few clinical trials have been carried out, it has attracted increasing attention with the increasing probability of its occurrence, especially considering that there are few successful cases.

Efficacy and safety of acupuncture for post-COVID-19 depression: a protocol for systematic review and meta-analysis.

Introduction: Post-COVID-19 depression (PCD) is a possible sequela of COVID-19. Some doctors have used acupuncture to treat PCD, but no systematic review or meta-analysis has yet evaluated its efficacy and safety for the treatment of PCD. The aim of this systematic review is to assess the efficacy and safety of acupuncture therapy for PCD.

Comparison of selected photon shield and organ-based tube current modulation for radiation dose reduction in head computed tomography: A phantom study.

Objective: The aim of this study is to investigate the radiation dose and image quality of head CT using SPS and OBTCM techniques.

Methods: Three anthropomorphic head phantoms (1-yr-old, 5-yr-old, and adult) were used. Images were acquired using four modes (Default protocol, OBTCM, SPS, and SPS+OBTCM).

Combined Tui na and Western medicine treatment improves pulmonary function and quality of life in patients with amyotrophic lateral sclerosis: A case report.

Rationale: Amyotrophic lateral sclerosis is a rare disease that cannot be cured. We report a case of a patient with amyotrophic lateral sclerosis whose pulmonary function and quality of life were improved by a combined tui na treatment and Western medicine.

Patient Concerns: A 48-year-old male was diagnosed with ALS 1 year ago and was treated with western medicine and herbal medicine with no significant effect.

NAC1 regulates root ground tissue maturation by coordinating with the SCR/SHR-CYCD6;1 module in Arabidopsis.

Precise spatiotemporal control of the timing and extent of asymmetric cell divisions (ACDs) is essential for plant development. In the Arabidopsis root, ground tissue maturation involves an additional ACD of the endodermis that maintains the inner cell layer as the endodermis and generates the middle cortex to the outside. Through regulation of the cell cycle regulator CYCLIND6;1 (CYCD6;1), the transcription factors SCARECROW (SCR) and SHORT-ROOT (SHR) play critical roles in this process.

Cooperative Regulation of Flagellar Synthesis by Two EAL-Like Proteins upon Salmonella Entry into Host Cells.

When Salmonella enters host cells, the synthesis of flagella is quickly turned off to escape the host immune system. In this study, we investigated the cooperative regulatory mechanism of flagellar synthesis by two EAL-like proteins, STM1344 and STM1697, in Salmonella. We found that Salmonella upregulated the expression of both STM1344 and STM1697 to various degrees upon invading host cells.

Predictive value of left ventricular dyssynchrony for short-term outcomes in three-vessel disease patients undergoing coronary artery bypass grafting with preserved or mildly reduced left ventricular ejection fraction.

Background And Objective: Coronary artery bypass grafting (CABG) is the reference standard intervention in coronary artery disease (CAD) patients with three-vessel disease (3VD). We aimed to evaluate the predictive value of left ventricular (LV) dyssynchrony for short-term adverse outcomes in patients with 3VD undergoing CABG with preserved or mildly reduced LV ejection fraction (LVEF).

Materials And Methods: This study involved ninety-five 3VD patients with preserved or mildly reduced LVEF undergoing scheduled on-pump CABG.