Decoding adenomyosis pathogenesis using an assembloid model.

Adenomyosis remains a challenging gynecological disorder to investigate due to the absence of in vitro models that accurately replicate endometrial tissue dynamics across the menstrual cycle. To address this gap, we established an endometrial assembloid model that faithfully mimics cycle-dependent endometrial responses and captures key cellular and molecular hallmarks of adenomyosis, including ectopic lesion- specific epithelial and stromal heterogeneity. Single-cell transcriptomics revealed that ectopic epithelial cells shift toward a luminal- dominant, glandular-deficient transcriptional profile during the secretory-like phase.

Localized Surface Phonon Polaritons and Infrared Optical Absorption of ScAlN Nanoresonators.

Alloying AlN with ScN provides a robust strategy for engineering its intrinsic bandgap, phonons and dielectric functions, and ScAlN alloys have demonstrated great promise in applications including the 5G mobile network, surface acoustic wave devices and nanophotonics. Sc doping has been shown to greatly influence the phonons and infrared dielectric functions of AlN, yet few studies have focused on its influence on surface phonon polaritons, which are crucial to modulating the radiative properties of ScAlN metasurfaces. Herein, we combined first-principles and finite element method (FEM) simulations to fully investigate the effects of Sc incorporation on the phonon dispersion relation, propagation and localization of SPhPs and the modulated radiative properties of ScAlN nanoresonators.

Atomic Real-Space Imaging of the Phase Distribution in Halide Perovskites.

Crystalline materials are not perfectly ordered periodic structures but present obvious disordered characteristics, which determine their intrinsic properties. Halide perovskites typically consist of ordered and disordered phases due to continuous octahedral rotations among the α, β, and γ phases. However, unraveling the spatial phase distribution requires a real-space imaging method with sufficient resolution.

Prognostic nomogram for heat stroke patients based on rapidly accessible clinical indicators.

Purpose: To develop and validate a rapid-assessment scoring system for predicting in-hospital mortality in heat stroke (HS) patients, thereby facilitating early identification and intervention for critical cases.

Approach: We conducted a retrospective cohort analysis of HS patients admitted to emergency department (ED) of 13 hospitals in southwest of China between July 1, 2022 and December 31, 2024. Clinical parameters including demographic data, initial vital signs, and major organ function biomarkers were systematically collected.

Associations of neutrophil-based inflammatory markers with all-cause and cardiovascular mortality in individuals with osteoarthritis.

Background: Osteoarthritis is increasingly understood as a heterogeneous disease, with certain phenotypes involving low-grade inflammation. Novel neutrophil-based inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR) and neutrophil-to-platelet ratio (NPR), have shown prognostic value in many disorders, but evidence for their relevance in osteoarthritis is limited. This study examined the associations between the NLR and NPR and all-cause and cardiovascular mortality in this population.

Analysis of the positive influence of Qianlie Shutong capsule combined with tamsulosin on prostate health of patients with prostatitis.

Chronic prostatitis (CP) is one of the most common health issues in the male urinary system. In this study, we included 110 patients with CP as research subjects and divided them into a research group receiving Qianlie Shutong Capsule (QLSTC) combined with tamsulosin and a control group receiving tamsulosin monotherapy. Comparing their clinical efficacy, we found that the total effective rate of treatment in the research group was higher than that in the control group (P<0.

Target density override in pencil beam scanning proton therapy for different motion target delineation: an experimental dosimetry analysis.

. This study aims to investigate the impact of target density override (TDO) on delivered dose in pencil beam scanning proton therapy (PBSPT) by experimental measurement.TDO was developed using the density characteristics of all target voxels, employing a sliding window approach.

A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease.

The exacerbation and recurrence of inflammatory bowel disease (IBD) are closely related to the overactivation of the immune system and the destruction of the intestinal mucosa. Current small-molecule and biopharmaceutical therapies for IBD are often limited by off-target effects, low bioavailability, and poor treatment outcomes, leading to systemic side effects and severe complications. To address these challenges, DNA gel bandage (DNAgb) designed to block immune cell homing and inhibit inflammatory responses are proposed.

FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.

Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe-sEVs) on ovariectomized (OVX)-induced bone loss. Inhibition of sEVs secretion by GW4869 partially reversed exercised-induced protection against OVX-induced bone loss.

The Clinical Significance of Non-Criteria Antiphospholipid Antibodies in Atypical Antiphospholipid Syndrome.

Objective: To analyse the correlation between non-criteria antiphospholipid antibodies (non-criteria aPLs) and clinical symptoms (recurrent miscarriage) in patients with seronegative antiphospholipid syndrome (SNAPS).Methods:Ninety-four SNAPS patients who were treated in the First Affiliated Hospital of Soochow University from May 2022 to May 2024 were included. Chemiluminescence immunoassay was used to detect anti-β2 glycoprotein I antibody (aβ2GPI), anti-cardiolipin antibody (aCL), and lupus anticoagulant.

Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop.

Aging-related accumulation of DNA damage adversely affects hematopoietic stem cell (HSC). However, the mechanisms underlying this accumulation and strategies for its elimination to rejuvenate aged HSCs remain largely obscure. This study uncovers a notable surge in R-Loop presence within aged HSCs, notably co-localized with γH2AX and RPA (Replication Protein A), and correlated with RNA residency in the nucleus.

Deletion of p18 enhances both osteogenesis and hematopoietic supportive capacity of bone marrow mesenchymal stromal cells.

Background: p18 (CDKN2C, encoded by p18 or Cdkn2c) is an early G1-phase cyclin-dependent kinase inhibitor protein. Previous studies demonstrated enhanced self-renewal capacity of hematopoietic stem cells (HSCs) in p18 mice compared to wild-type (WT) mice. Given the critical role of bone marrow niche cells-particularly mesenchymal stromal cells (MSCs)-in hematopoiesis, this study investigated the functional alterations of p18 MSCs and their impact on hematopoietic support.

Correlations of serum histone deacetylase 3 and thrombospondin-1 levels with cardiac function grades, ventricular remodeling, and prognosis in patients with chronic heart failure.

Background: This study aims to analyze the relations of serum Histone Deacetylase 3 (HDAC3) and Thrombospondin-1 (TSP-1) levels to cardiac function grades, ventricular remodeling, and prognosis of patients with chronic heart failure (CHF).

Methods: We conducted a retrospective analysis of 128 enrolled CHF patients, with 102 healthy individuals as controls. Baseline data and two-year follow-up records were collected to assess prognosis.

Investigating the Mechanism of Selective Adsorption of Nucleoside Compounds by Hydrophilic Flower-Like Zr-MOF Nanosheets.

Metal-organic frameworks (MOFs) exhibit a diverse array of applications in the fields of adsorption, catalysis, sensing, and separation. However, the limited water stability of MOFs poses challenges in the separation domain, particularly due to the structural similarities among water-soluble nucleoside compounds, which complicate the selective adsorptive separation of these compounds from complex mixtures. In this study, hydrophilic flower-like zirconium-based MOF nanosheets (Zr-FNSs) were prepared by a one-step hydrothermal method.

Pneumonectomy after neoadjuvant immunotherapy combined with chemotherapy is a safe and effective option for central non-small-cell lung cancer patients, a single-center experience.

Background: The safety and effectiveness of pneumonectomy in non-small cell lung cancer (NSCLC) patients receiving neoadjuvant immunotherapy have not been specifically studied despite the significant outcomes seen in the neoadjuvant immunotherapy of NSCLC. This article aims to investigate the safety and efficacy in such cases.

Methods: We retrospectively analyzed NSCLC patients who underwent pneumonectomy at Zhongshan Hospital of Fudan University from 2014 to 2022 and divided them into the no-induction therapy group and the induction therapy group.

Integrating magnetic field-initiated thermal-thermodynamic therapy and immune checkpoint blockade to boost antitumor immunotherapy.

Immune checkpoint blockade (ICB) immunotherapy has transformed cancer treatment by unleashing anti-tumor immune responses. However, its effectiveness in solid tumors is often limited by weak or insufficient immune activation. Herein, an immune-adjuvant strategy has been developed by integrating ICB and alternating magnetic field (AMF) activatable nanoagents to augment antitumor immunotherapy.

Temperature-dependent infrared dielectric function and localized surface phonon polaritons in polar AlN.

Aluminum nitride (AlN)-based optoelectronics have demonstrated great promises in application scenarios such as waveguides, beam splitters, directional couplers and interferometers. Yet, existing studies primarily focus on its photonic applications in the UV-Vis spectrum, with limited exploration in the mid and long IR spectrum. With its strong polarity, AlN can host the surface phonon polaritons (SPhPs) and modulate radiative properties via inducing localized resonances in metasurface.

Investigation of flow-induced noise reduction in high-specific-speed centrifugal pumps using bionic blades.

To reduce the flow-induced noise of centrifugal pumps and reveal the noise source characteristics inside the pumps, this paper designs a bionic blade based on the "tubercle effect" of humpback whales. The noise reduction effect of the improved structure is verified through numerical simulations of the flow and acoustic fields of the prototype pump and bionic pump. Using the Ffowcs Williams-Hawkings equation and Powell vortex sound equation, the reasons for the noise reduction are explained from the perspective of pressure pulsation and sound source.

Engineering catalyst-support interactions in cobalt phthalocyanine for enhanced electrocatalytic CO reduction: the role of graphene-skinned AlO.

Electrocatalytic CO reduction (eCOR) driven by renewable electricity holds great promise to mitigate anthropogenic CO emissions. In this study, we engineer cobalt phthalocyanine (CoPc) supported on graphene-skinned AlO nanosheets (CoPc/AlO@C) to enhance CO-to-CO conversion. The strong π-π stacking between the CoPc macrocycle and interlayer graphene, coupled with electronic repulsion between the Co center and AlO, induces a structural distortion in CoPc, raising the energy level of the d orbital.

Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin.

Background: Since the discovery of streptomycin in the 1940s, more than a dozen drugs have been continuously introduced into tuberculosis (TB) therapy. However, limited attention has been paid to the collateral effects of drug resistance evolution in Mycobacterium tuberculosis (Mtb). Recently, we observed a clear discordance between the capreomycin (CAP) susceptibility of rifampicin-resistant (RR) Mtb clinical isolates and the adverse outcomes associated with CAP treatment, indicating potential collateral effects between rpoB mutations and CAP.

A retrospective study on unfavorable 28-day neurological outcomes of stage II TB meningitis.

Tuberculous meningitis (TBM) is often associated with adverse neurological outcomes, however, there is a lack of relevant research. The aim of this study is to explore the risk factors that affect the poor prognosis of 28-day neurological function in patients with stage II TBM. A retrospective analysis was conducted on the clinical data of patients with stage II TBM who visited our hospital from January 1st, 2018 to August 1st, 2019 based on the staging criteria of the Medical Research Council.

Professionalism vs. engagement: quality of SSc information on WeChat.

Background: Systemic sclerosis (SSc) is a rare autoimmune disease, and WeChat is a major source of health information in China. This study assesses the quality of SSc information on WeChat to understand its impact on public knowledge and engagement.

Methods: A total of 375 articles from 9 WeChat public accounts were systematically analyzed using the DISCERN and Global Quality Scale (GQS) tools.