The Association Between Sensory Impairment and Cognitive Impairment Among Older Adults: Insights From a National Cohort Study in China.

Objectives: Cognitive impairment and sensory impairment are highly prevalent in older adults, but the relationship between the two remains inconclusive. This study aimed to investigate the relationship between visual impairment (VI), hearing impairment (HI), dual sensory impairment (DSI), and the onset of cognitive impairment among Chinese older adults.

Methods: Data were obtained from the 2011-2018 China Longitudinal Healthy Longevity Survey (CLHLS) cohort.

Differentiation Between Fibro-Adipose Vascular Anomaly and Intramuscular Venous Malformation Using Grey-Scale Ultrasound-Based Radiomics and Machine Learning.

To establish an ultrasound-based radiomics model to differentiate fibro adipose vascular anomaly (FAVA) and intramuscular venous malformation (VM). The clinical data of 65 patients with VM and 31 patients with FAVA who were treated and pathologically confirmed were retrospectively analyzed. Dimensionality reduction was performed on these features using the least absolute shrinkage and selection operator (LASSO).

Predictive Ability of an Objective and Time-Saving Blastocyst Scoring Model on Live Birth.

With the development of artificial intelligence technology in medicine, an intelligent deep learning-based embryo scoring system (iDAScore) has been developed on full-time lapse sequences of embryos. It automatically ranks embryos according to the likelihood of achieving a fetal heartbeat with no manual input from embryologists. To ensure its performance, external validation studies should be performed at multiple clinics.

[Attribution Analysis of Vegetation Variation in the Karst Region of Southwest China Considering Time Lag and Accumulation Effects].

Assessing the effects of climate change and human activities on vegetation changes in the karst region of southwest China is of great significance for the sustainable development of karst ecosystems. Based on the GIMMS NDVI and SPOT NDVI fusion data， combined with precipitation and temperature meteorological station data from 1982 to 2019， the effects of climate change and human activities on vegetation changes before and after the ecological restoration projects （ERPs） were investigated by using trend analysis， partial correlation analysis， and modified residual analysis. The results showed that： ① Temporally， the trend of NDVI had shifted from a slow decrease （>0.

China's Well-Facilitated Farmland distribution dataset.

China has less than 10% of the world's arable land but must feed more than 20% of the global population. Both climate change and farmland degradation pose significant challenges to China's food security. In 2009, Chinese government launched a nationwide, well-facilitated farmland (WFF) construction strategy to improve food production.

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3.

Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function in preimplantation embryonic development and its potential involvement in epigenetic regulation remain poorly understood. In this study, it is shown that MFN1 interacts with PADI6, a key component of the cytoplasmic lattice in oocytes and early embryos.

Real-World Effectiveness of 3 Types of Acellular Pertussis Vaccines Among Children Aged 3 Months-16 Years in Lu'an, China: A Matched Case-Control Study.

Background: The real-world vaccine effectiveness (VE) of the diphtheria, tetanus, and acellular pertussis (DTaP), DTaP- type b (Hib), and DTaP-inactivated polio (IPV)/Hib vaccines has not been thoroughly evaluated in China. Additionally, there are limited data on the VE of acellular pertussis-containing vaccines (aPVs) when used interchangeably.

Methods: We conducted a matched case-control study to estimate the VE of aPVs against polymerase chain reaction-confirmed pertussis infection in Lu'an in 2024.

The Prediction Model of High-Frequency Ultrasound Combined with Artificial Intelligence-Assisted Scoring System Improved the Diagnosis of Sclerosing Adenosis and Early Breast Cancer.

Objective: The study aimed to apply an artificial intelligence (AI)-assisted scoring system, and improve the diagnostic efficiency of Sclerosing adenosis and early breast cancer.

Methods: This study retrospectively collected adenopathy patients (156 cases) and early breast cancer patients (150 cases) in Henan Provincial People's Hospital from August 2020 to April 2023.

Results: The area under the curve of the model constructed by clinical ultrasound features and combined AI features to predict and identify the two in the training group was 0.

Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.

Quantification of transcription activities in mammalian preimplantation embryos is challenging due to a huge amount of maternally stored transcripts and paucity of research materials. Here, we investigate genome-wide transcription activities of mouse and human preimplantation embryos by quantifying elongating RNA polymerase II. Two transcriptional waves are identified in early mouse embryos, with summits at the 2-cell and 8-cell stages.

Preimplantation development analysis of aneuploid embryos with different chromosomal abnormalities.

Background: The change of morphokinetic pattern in aneuploid embryos will facilitate the non-invasive selection of euploid embryos. In this study, we investigated the impact of different chromosomal abnormalities on the morphokinetic patterns of embryonic development.

Methods: Our cohort includes 939 time-lapse preimplantation genetic testing cycles performed between January 2019 and July 2022 at a single academic fertility center, with a total of 2876 biopsied blastocysts.

Dielectric barrier discharge-mediated one-pot rapid synthesis of platinum nanoclusters for fluorescent sensing of malachite green.

A one-pot method using a dielectric barrier discharge microplasma reactor was employed to rapidly and conveniently prepare glutathione-protected platinum nanoclusters (GSH@PtNCs) with green fluorescence emission. Based on the inner filter effect (IFE), the synthesized GSH@PtNCs were utilized to achieve fast, sensitive and selective detection of malachite green.

Outcomes of different transfer strategies for in vitro fertilization/intracytoplasmic sperm injection with poor-quality embryos-Analysis of embryonic development, perinatal period, and neonatal outcomes.

During the in vitro fertilization and embryo transfer process, some expectant mothers may not have good embryos to choose from before the embryo transfer. Recommendations for this condition are currently unclear, and relevant clinical and neonatal outcomes are still lacking. This study analyzed the outcomes of poor-quality embryo transfers, including fetal outcomes, in the fresh cycle and frozen-thawed embryo transfer cycle.

Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study.

Background: Obesity poses a significant global health challenge, with profound implications for women's reproductive health. The relationship between ovarian reserve and body mass index (BMI) remains a subject of debate. While obesity is generally associated with poorer outcomes in assisted reproductive technology (ART), the evidence remains inconclusive.

The Interplay between nighttime/midday sleep duration and the number of new-onset chronic diseases: A decade-long prospective study in China.

Objective: To investigate the interplay between individual nighttime and midday sleep duration and the number of new-onset chronic diseases and determine the optimal sleep duration associated with lowest number of new-onset chronic diseases.

Methods: We used data from the China Health and Retirement Longitudinal Study (CHARLS) covering a decade and involving 10,828 participants. A random intercept cross-lagged model was used to explore the interplay between nighttime/midday sleep durations and new-onset chronic diseases at both the within-individual and between-individual levels, followed by a dose-response analysis at the between-individual level to determine the optimal sleep duration.

The density of the inner cell mass is a new indicator of the quality of a human blastocyst: a valid supplement to the Gardner scoring system.

Study Question: Can the density of the inner cell mass (ICM) be a new indicator of the quality of the human blastocyst?

Summary Answer: The densification index (DI) developed in this study can quantify ICM density and provide positive guidance for ploidy, pregnancy, and live birth.

What Is Known Already: In evaluating the quality of ICM, reproductive care clinics still use size indicators without further evaluation. The main disadvantage of this current method is that the evaluation of blastocyst ICM is relatively rough and cannot meet the needs of clinical embryologists, especially when multiple blastocysts have the same ICM score, which makes them difficult to evaluate further.

Multiple collapses of blastocysts after full blastocyst formation is an independent risk factor for aneuploidy - a study based on AI and manual validation.

Background: The occurrence of blastocyst collapse may become an indicator of preimplantation embryo quality assessment. It has been reported that collapsing blastocysts can lead to higher rates of aneuploidy and poorer clinical outcomes, but more large-scale studies are needed to explore this relationship. This study explored the characteristics of blastocyst collapse identified and quantified by artificial intelligence and explored the associations between blastocyst collapse and embryo ploidy, morphological quality, and clinical outcomes.

Enhancing clinical utility: deep learning-based embryo scoring model for non-invasive aneuploidy prediction.

Background: The best method for selecting embryos ploidy is preimplantation genetic testing for aneuploidies (PGT-A). However, it takes more labour, money, and experience. As such, more approachable, non- invasive techniques were still needed.

A novel non-invasive embryo evaluation method (NICS-Timelapse) with enhanced predictive precision and clinical impact.

The selection of the finest possible embryo in in-vitro fertilization (IVF) was crucial and revolutionary, particularly when just one embryo is transplanted to lessen the possibility of multiple pregnancies. However, practical usefulness of currently used methodologies may be constrained. Here, we established a novel non-invasive embryo evaluation method that combines non-invasive chromosomal screening (NICS) and Timelapse system along with artificial intelligence algorithms.

Understanding community-dwelling older adults' preferences for home- and community-based services: A conjoint analysis.

Background: Older adults' preference for home- and community-based service programs has been highlighted as an essential but usually ignored ingredient in current care models. Disentangling how preferences contribute to older adults' decision-making could facilitate finding optimal ways to deliver home- and community-based services in times of increasing scarcity.

Objective: To identify Chinese community-dwelling older adults' preference structure for home- and community-based services and thus to optimize service provision.

Regulation of cleavage embryo genes upon DRP1 inhibition in mouse embryonic stem cells.

Dynamic-related protein 1 (DRP1) is a key protein of mitochondrial fission. In this study, we found that inhibition of activity of DRP1 led to increased levels of cleavage embryo genes in mouse embryonic stem cells (mESCs), which might reflect a transient totipotency status derived from pluripotency. This result indicates that DRP1 inhibition in mESCs leads to a tendency to obtain a new expression profile similar to that of the 2C-like state.

Virtual Screening of Nrf2 Dietary-Derived Agonists and Safety by a New Deep-Learning Model and Verified and .

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an essential regulatory target of antioxidants, but the lack of Nrf2 active site information has hindered discovery of new Nrf2 agonists from food-derived compounds by large-scale virtual screening. Two deep-learning models were separately trained to screen for Nrf2-agonists and safety. The trained models screened potentially active chemicals from approximately 70,000 dietary compounds within 5 min.

Are Early Embryo Cleavage Kinetics Affected by Energy Substrates in Different Culture Media?

Objective: This study aimed to investigate the influence of different culture media on early embryonic cleavage kinetics using time-lapse analysis and to determine the possible relationships between energy substrates in culture media and the cleavage kinetics.

Methods: A total of 10 021 embryos from 1310 couples were cultured in time-lapse incubators. Embryos cultured in Vitrolife media were allocated to group I, and those in COOK media to group II.

Artificial intelligence in elderly healthcare: A scoping review.

The ageing population has led to a surge in the adoption of artificial intelligence (AI) technologies in elderly healthcare worldwide. However, in the advancement of AI technologies, there is currently a lack of clarity about the types and roles of AI technologies in elderly healthcare. This scoping review aimed to provide a comprehensive overview of AI technologies in elderly healthcare by exploring the types of AI technologies employed, and identifying their roles in elderly healthcare based on existing studies.