Association Between the Presence of Missed Canals, Detected Using CBCT, and Post-Treatment Apical Periodontitis in Root-Filled Teeth: A Systematic Review and Meta-Analysis.

Post-treatment apical periodontitis (PAP) is a frequent consequence of root canal treatment (RCT) failure, often caused by untreated missed canals in root-filled teeth (RFT). While cone-beam computed tomography (CBCT) has been used to find these missed canals, the results are controversial. This systematic review and meta-analysis investigates the association between PAP in RFT and missed canals detected via CBCT.

Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.

: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs.

Ethical and secure evidence generation from regionwide clinical data through a collaborative environment for advancing predictive care.

Ensuring data protection is a major challenge in clinical research involving sensitive patient information. However, secure processing environments (SPEs) enable the ethical and compliant secondary use of real-world data (RWD) for evidence generation. This study presents a collaborative infrastructure integrating a comprehensive Health Population Database (BPS) with a legal and computational framework to facilitate secure, large-scale clinical studies.

Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial.

Background: Limited research has been done to evaluate the combined effect of energy reduction, Mediterranean diet (MedDiet), and physical activity on type 2 diabetes incidence.

Objective: To evaluate whether an energy-reduced MedDiet (erMedDiet) plus physical activity reduces diabetes incidence compared with a standard MedDiet.

Design: Prespecified secondary outcome analysis in the PREDIMED (Prevención con Dieta Mediterránea)-Plus randomized, single-blinded, controlled trial.

Trace metal contamination along an estuarine gradient under increasing anthropogenic pressure: A case study from the Guadalquivir estuary (SW Iberian Peninsula).

This study investigates trace metal contamination in the Guadalquivir Estuary (SW Spain), a historically impacted system influenced by both past and ongoing mining. Over two years (2022-2023), sediment and water samples were collected at 15 stations along the estuarine gradient. The objective was to provide a comprehensive assessment of current contamination levels before the onset of discharges from newly approved mining projects.

Rheumatoid arthritis exacerbates apical periodontitis in Wistar rats, increasing IL-17, TNF-α, TRAP, and RANKL levels.

This study aimed to evaluate the influence of rheumatoid arthritis on the inflammatory and resorptive process of periapical lesions in an animal model. Forty Wistar rats were divided into four groups (n = 10): control (C), apical periodontitis (AP), rheumatoid arthritis (RA), and AP + RA. RA was induced by two injections into the caudal subcutaneous tissue containing 50 µL volume of methylated bovine albumin (Met-BSA, 40 mg/mL) and 5% glucose emulsified with CFA/complete Freund's adjuvant (Mycobacterium sp), and a third intra-articular injection in the right knee with half of the same solution.

Diaphragmatic breathing for referred pain after total laparoscopic hysterectomy: a randomized clinical trial.

Background: Referred cervicoscapular pain is common after laparoscopic surgery. This pain has different characteristics from incisional pain and requires a different approach.

Method: A blinded, randomized, controlled trial was conducted.

Temporal and Spatial Changes of Native and Alien Plant Assemblages Ecological Strategies in Response to Chronic Disturbances.

Background And Aims: Successional theory predicts directional shifts in plant community composition following disturbance. However, the long-term effects of chronic, recurring disturbances on plant ecological strategies at the community-level in human-altered landscapes, and how they differ between the assemblages of native and alien species, remain poorly understood.

Methods: Using Grime's competitor, stress-tolerator, ruderal (CSR) framework, we examine temporal and spatial changes in plant strategies at the community-level in the Three Gorges Reservoir Area, China.

Implementing early care protocol for obsessive-compulsive disorder: A scalable model for public mental health services.

Obsessive-Compulsive Disorder (OCD) is a prevalent and burdensome mental health condition associated with significant impacts on quality of life and elevated risks of mortality. It frequently presents with a prolonged Duration of Untreated Illness (DUI), which is linked to poor outcomes. This study presents an early intervention protocol for individuals with recent-onset OCD (< 24 months) designed for systematic implementation within the universal public healthcare system in Spain.

Proteomic Profiling of Dentinal Fluid for the Identification of Biomarkers in Pulpal Inflammation: An Exploratory Study.

Aim: To identify differentially expressed proteins (DEPs) in dentinal fluid across a range of pulpal inflammatory stages-mild, moderate, severe pulpitis-using mass spectrometry.

Methodology: This cross-sectional study analysed dentinal fluid from 60 patients categorised into healthy pulp (control), mild, moderate and severe pulpitis groups, based on Wolters' pulp diagnostic criteria. Pulp conditions were assessed through cold sensibility tests and radiographs, with inclusion limited to patients aged 12-40, who were systemically healthy and exhibited no advanced periodontal or apical pathology.

Evaluation of potential androgenic and antiandrogenic activities of pure cyanotoxins (microcystin-LR and cylindrospermopsin) using the hershberger bioassay (OECD TG 441).

Cyanotoxins, produced by cyanobacteria, pose significant health risks due to their acute and chronic toxic effects on humans and animals. Among these toxins, microcystins (MCs) and cylindrospermopsin (CYN) have shown potential as endocrine disruptors, as they affect hormonal regulation and reproductive processes, particularly through interference with key hormonal signalling pathways. In this study, the Hershberger bioassay was employed to assess the (anti)androgenic effects of MC-LR and CYN (22.

Relationship Between Bruxism and Obstructive Sleep Apnea: A Systematic Review of the Literature.

: The interest in studying the relationship between bruxism and sleep apnea has increased over the past decade, given its prevalence and its implications for both oral and overall health. Bruxism occurs in a significant portion of the population, with an overall incidence ranging between 8 and 31%. Obstructive sleep apnea affects 4-6% of middle-aged men and 2-4% of middle-aged women, and it is associated with diminished quality of life, hypertension, increased cardiovascular risks, traffic accidents, and a higher mortality rate.

Undergraduate Endodontic Teaching in Dental Schools Around the World: A Narrative Review.

This narrative review aims to analyze the published data regarding undergraduate teaching of Endodontics throughout the world. A literature survey was conducted to identify articles about undergraduate endodontic teaching, using the following combinations of keywords: (endodontic OR endodontics OR endodontology) AND (teaching OR training OR education OR curriculum) AND (undergraduate OR pre-graduate) AND (evaluation OR assessment) AND (dental schools OR dental faculty). The inclusion criteria established were studies published in the last 10 years, in which those responsible for teaching endodontics reported some data about the undergraduate training of endodontics in dental schools around the world.

Advanced feature engineering in Acute:Chronic Workload Ratio (ACWR) calculation for injury forecasting in elite soccer.

Controlling training monotony and monitoring external workload using the Acute:Chronic Workload Ratio (ACWR) is a common practice among elite soccer teams to prevent non-contact injuries. However, recent research has questioned whether ACWR offers sufficient predictive power for injury prevention in elite competition settings. In this paper, we propose a novel feature engineering framework for training load management, inspired by bilinear modeling and signal processing principles.

A single dose of corifollitropin alfa is equipotent to a daily dose of 300 IU recombinant FSH regardless of ovarian reserve.

Research Question: What dose of daily recombinant FSH (recFSH) provides a similar ovarian response as a single dose of corifollitropin alfa (CFA) overall and in women with different ovarian reserves?

Design: This retrospective analysis of three randomized trials included 1715 patients who received a single injection of CFA and 1577 patients who were treated with daily follitropin beta with a fixed starting dose for the first week of stimulation. Data were adjusted for antral follicle count (AFC), age, body weight, and interaction between AFC and age. The dose of follitropin beta corresponding to CFA was estimated by including log(dose) as a covariate in the model.

Impact of a Multimodal Intervention Combining Manual Therapy, Exercise, Reduced Methylxanthine Intake, and Nocturnal Light Avoidance on Inflammatory and Metabolic Profiles, Pain, Functionality, and Sleep Quality in Patients with Frozen Shoulder: A Single-Blind Randomized Controlled Trial.

Frozen shoulder (FS) is a common musculoskeletal condition with significant socioeconomic impact. Despite its prevalence, the condition lacks a definitive understanding and universally effective treatment approach. To evaluate the effects of an intervention combining manual therapy, conventional exercises, and strategies to improve sleep quality and circadian rhythm on recovery and biomarkers in patients with FS.

Can 3D Imaging Improve Results in Colorectal Cancer Laparoscopic Surgery?

The aim of this prospective comparative study is to report our experience with 3D laparoscopy in terms of surgeon's discomfort with 3D vision, and to compare clinical outcomes with 2D laparoscopy in oncological colorectal surgery. From 2016 to 2017, all consecutive patients who underwent elective colorectal surgery for malignancy were enrolled. Based on surgery, patients were grouped as follows: group A, right hemicolectomy; group B, left hemicolectomy; group C, sigmoidectomy; and group D, anterior resection of the rectum.

Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma.

Unlabelled: Multiple myeloma remains incurable despite advances in immunotherapies like chimeric antigen receptor (CAR) T-cell therapy. This study investigates the role of metabolites and gut microbiota in clinical outcomes in patients treated with the humanized B-cell maturation antigen (BCMA)-directed CAR-T therapy ARI0002h. Stool metabolites, particularly succinate, were associated with CAR T-cell phenotypes and persistence in patients.

Diabetes mellitus influences Toll-like receptors 2 and 4 in experimental apical periodontitis of Wistar rats.

The aim of this study was to investigate the inflammatory profile and immunostaining expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) in periapical tissues of control and diabetic rats (DM) with induced apical periodontitis (AP), correlating these findings with the progression of root canal contamination. Forty male Wistar rats were divided into four groups: Group C-control rats, Group AP-rats with AP, Group DM-rats with diabetes, and Group DM + AP-rats with DM and AP. DM was induced using streptozotocin, and AP was induced by dental pulp exposure of the first mandibular molar to the oral environment.

sp. nov., a moderately halophilic and alkaliphilic bacterium isolated from an inland saltern in central Portugal and reclassification of as sp. nov.

A novel moderately halophilic and alkaliphilic Gram-stain-negative, strictly aerobic, bacterial strain (N2) was isolated from an inland saltern in central Portugal. The taxonomic position of this isolate was determined based on polyphasic taxonomic and phylogenomic analysis. Phylogenetic analysis based on 16S rRNA gene sequences indicated that isolate N2 belongs to the genus , showing the highest similarity to 2W32 (98.

Judicial Opinion 132.

Opinion 132 deals with a Request for an Opinion asking the Judicial Commission to assess the nomenclatural status of (Blackall 1989) Chun 1997, a new combination affected by an unusual change in the epithet of its basonym, Blackall 1989. This is done by re-evaluating Opinion 85, which sets a precedent. The reasons and consequences of this earlier Opinion are explained in detail, and corresponding guidelines for orthographic corrections are given, along with further guidance derived from more recently published Judicial Opinions.

Fusobacterium nucleatum is not significantly present in eutopic endometrium from patients with minimal-mild and moderate-severe endometriosis.

Objective: To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls, and assess their association with the disease.

Design: Retrospective case-control study.

Online Mental Contrasting with Implementation Intentions for changing snacking behavior and reducing body mass index in people with excess weight: a randomized controlled trial.

Mental Contrasting with Implementation Intentions (MCII) has proved useful for dietary changes, but not yet applied to people with excess weight. We aimed to determine the benefit of online MCII as an add-on to a standard Behavioral Weight Loss Intervention (Treatment as Usual-TAU) to change snacking behavior -one of the main contributors to excess weight- and reduce BMI. This online randomized controlled trial included 148 participants [MCII-group (50), Sham-group (50) and TAU-group (48)].

Minimally invasive approach for inguinoscrotal hernia repair. A systematic literature review.

Background: This systematic review reports the presently available evidence regarding the results of the minimally invasive surgery (MIS) approach for the treatment of inguinoscrotal hernias (ISHs).

Methods: After PROSPERO registration (CRD-42023493129), a search was performed in the MEDLINE, Embase, and Web of Science databases.

Results: One-thousand-fifty-two patients were included (78.