Altered protein lipidation in cancer: A hidden link to sensory neuronal dysfunction.

Protein lipidation/delipidation affects protein functions, interactions, and membrane trafficking. Dysregulation of this process might lead to tissue disorganization, abnormal proliferation, migration, and poor prognosis in cancer. While dysregulation of lipidation/delipidation in neurons has been associated with several neurodegenerative diseases, its potential link to neuronal dysfunction in cancer patients remains unexplored.

Coordinated regulation of pH alkalinization by two transcription factors promotes fungal commensalism and pathogenicity.

As a clinically relevant opportunistic human fungal pathogen, Candida albicans is able to rapidly sense and adapt to changing microenvironments within the host, a process that is essential for its successful invasion and survival. Although studies have shown that the transcription factor Stp2 is the master regulator of environmental alkalinization, accumulating evidence supports a clear involvement of other participants in this adaptation process. Here, following a large-scale genetic screen, we identify the transcription factor Dal81 as an uncharacterized positive regulator of pH alkalinization in C.

Presence of high-risk nano particulate matters in powder injection: microscopic evaluation and investigation of particles contamination.

To analyse the health hazard particles in injection. By using different analytical techniques, we have found nanoparticles within injections. Complex parenteral products are prone to particulate issues that may pose safety and quality risks.

Poor sleep quality among patients with Parkinson's disease: a meta-analysis and systematic review.

Objective: Poor sleep quality is common among patients with Parkinson's disease (PD), although the reported prevalence rates vary between studies. This meta-analysis examined the overall prevalence of poor sleep quality in patients with PD and identified potential factors contributing to the differences in prevalence across studies.

Methods: Both PRISMA and MOOSE guidelines were applied in this meta-analysis.

Physiological and behavioral responses of seahorse newborns to acute hypoxia.

Seahorse populations have been declining globally as a result of intensive anthropogenic activities. However, knowledge about the impacts of climate change on these charismatic organisms is still scarce. Considering their vulnerability and current conservation status, it is crucial to comprehend how these species cope with stress from rapid climate change, particularly in early life stages, known to be particularly vulnerable to environmental stress.

Exploration of Psychosocial Hazards: Core Values, Justice and Fairness, and Social Support to Address Workforce Well-Being.

Objectives: Institutions of higher learning have been challenged with high rates of turnover among faculty, administrators, and staff. Pharmacy educators face unique challenges linked to workplace stress and burnout. Efforts from the year-long work of a Council of Faculties and Council of Deans Taskforce led to the adoption of the 6 areas of work-life definitions as they apply to pharmacy academia and the identification of psychosocial hazards within these work-life areas.

sp. nov., a moderately halophilic and alkaliphilic bacterium isolated from an inland saltern in central Portugal and reclassification of as sp. nov.

A novel moderately halophilic and alkaliphilic Gram-stain-negative, strictly aerobic, bacterial strain (N2) was isolated from an inland saltern in central Portugal. The taxonomic position of this isolate was determined based on polyphasic taxonomic and phylogenomic analysis. Phylogenetic analysis based on 16S rRNA gene sequences indicated that isolate N2 belongs to the genus , showing the highest similarity to 2W32 (98.

Exploring the biodegradation of PET in mangrove soil and its intermediates by enriched bacterial consortia.

The biodegradation of Polyethylene terephthalate (PET) is important due to the environmental impact of plastic waste. This study investigates the degradation of PET films in soil microcosms, with and without mangrove plants, and with mangrove plants bioaugmented with a bacterial consortium ( sp.- GPB12 and sp.

Cord blood cytokines/chemokines linked to delays in toddlers exposed to SARS-CoV-2 prenatally.

Background: Maternal infections are linked to neurodevelopmental impairments, highlighting the need to investigate SARS-CoV-2-induced immune activation.

Objective: This study aimed to evaluate the impact of maternal infection on neurodevelopment and investigate whether cytokine and chemokine profiles predict delays at 24 months.

Methods: Conducted in Brazil (January 2021-March 2022), this follow-up study included 18 SARS-CoV-2 positive pregnant women at 35-37 weeks' gestation, 15 umbilical cord blood samples, and blood samples from 15 children at 6 months and 14 at 24 months.

Evaluating a Three-Pronged Self-Assessment Tool to Enhance Communication Skills in First-Year Pharmacy Students: A Multi-Institutional Study.

Objective: To evaluate the impact of a novel, three-pronged self-assessment tool on the verbal and nonverbal communication skills of first-year pharmacy (P1) students at two Schools of Pharmacy.

Methods: This study, conducted during the 2022-2023 academic year, involved 200 P1 students from two institutions. Students recorded a patient counseling session and utilized the three-pronged tool to self-assess their performance in 3 distinct phases: (1) video-only review for evaluating nonverbal communication, (2) audio-only review for assessing verbal communication, and (3) a combined audio and video review for a comprehensive assessment.

Parenting Style and Child Internet Addiction in China: Mediation Effect of Parental Active Meditation.

With the rapid advancement of technology, internet addiction among children has become a growing concern, particularly in China. This study examines the impact of different parenting styles on internet addiction and the role of parental mediation on the relationship among Chinese children. A survey of 600 Chinese families with children aged 6 to 17 was conducted in 2024.

Vasotocin and oxytocin modulation of the endocrine and behavioral response to an aggressive challenge in male Siamese fighting fish.

Aggressive behavior is an adaptive trait present across all taxa. However, the neuroendocrine mechanisms regulating it, particularly in fish, are not well understood. Oxytocin (OXT) and arginine vasotocin (VT) are known modulators of aggression, but their actions remain controversial.

Liver Fat Quantification With Ultrasound: The Influence of the Size of the Region of Interest on Attenuation Coefficient.

Noninvasive assessment of liver fat content is crucial due to the high global prevalence of nonalcoholic fatty liver disease. Algorithms based on ultrasound (US) attenuation coefficient (AC) for estimating liver fat content are commercially available, but a lack of consensus exists regarding the best estimation protocol. The aim of our study was to evaluate the influence of the size of the region of interest (ROI) on the US AC.

Prevalence of internet addiction among Chinese adolescents: A comprehensive meta-analysis of 164 epidemiological studies.

Background: Internet Addiction (IA) among Chinese adolescents is a growing concern that is associated with considerable psychological, social, and academic problems. Although numerous past studies on IA prevalence in China have been conducted, the findings have been mixed. This meta-analysis aimed to examine the pooled IA prevalence among adolescents in China and its associated factors.

Robotic sacrocolpopexy: a game worth playing? A critical literature analysis.

Robotic sacrocolpopexy is an advanced minimally invasive technique for the surgical management of urogenital prolapse. It offers superior precision, reduced blood loss, and lower conversion rates compared to traditional approaches. However, longer operative times, higher costs, and the need for specialized training remain the most significant challenges of robotic surgery.

The gut-heart axis: a review of gut microbiota, dysbiosis, and cardiovascular disease development.

Background: Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality worldwide and there are strong links existing between gut health and cardiovascular health. Gut microbial diversity determines gut health. Dysbiosis, described as altered gut microbiota, causes bacterial translocations and abnormal gut byproducts resulting in systemic inflammation.

Application of Multiple Deep Learning Architectures for Emotion Classification Based on Facial Expressions.

Facial expression recognition (FER) is essential for discerning human emotions and is applied extensively in big data analytics, healthcare, security, and user experience enhancement. This study presents a comprehensive evaluation of ten state-of-the-art deep learning models-VGG16, VGG19, ResNet50, ResNet101, DenseNet, GoogLeNet V1, MobileNet V1, EfficientNet V2, ShuffleNet V2, and RepVGG-on the task of facial expression recognition using the FER2013 dataset. Key performance metrics, including test accuracy, training time, and weight file size, were analyzed to assess the learning efficiency, generalization capabilities, and architectural innovations of each model.

Understanding and Reacting to Relapse: Considerations for Practitioners.

Severe challenging behaviors, such as aggression and self-injurious behavior, have a high comorbidity with autism spectrum disorder (ASD; Hill et al., 2014; Soke et al., 2016).

BERT-AmPEP60: A BERT-Based Transfer Learning Approach to Predict the Minimum Inhibitory Concentrations of Antimicrobial Peptides for and .

Antimicrobial peptides (AMPs) are a promising alternative for combating bacterial drug resistance. While current computer prediction models excel at binary classification of AMPs based on sequences, there is a lack of regression methods to accurately quantify AMP activity against specific bacteria, making the identification of highly potent AMPs a challenge. Here, we present a deep learning method, BERT-AmPEP60, based on the fine-tuned Bidirectional Encoder Representations from Transformers (BERT) architecture to extract embedding features from input sequences.

Effect of microbe-derived antioxidants on intestinal oxidative stress, NLRP3 inflammasome, morphologic structure, and growth performance in weanling piglets.

Weaning stress induces pigs oxidative stress, which decreases growth performance, causes intestinal damage, and increases diarrhea and death in piglets. Microbe-derived antioxidants (MA) have an antioxidant and immune-modulatory role, but the impacts of MA on growth performance, intestinal oxidative stress, structure and function, and inflammatory response of weaned piglets are unclear. To elucidate whether MA can modulate intestinal oxidative stress, inflammatory response, and barrier function impairment and the possible mechanisms of its modulation, a total of 60 DLY (a crossbreed of Duroc, Landrance, and Yorkshire) piglets were randomly selected from 6 litters, with 10 piglets from each litter.

Advocating microbial diversity conservation in Antarctica.

Antarctica, a seemingly barren and icy wilderness, is home to a diverse array of microbial life that plays a critical role in sustaining its ecosystems. These resilient microorganisms drive nutrient cycling and carbon sequestration, but their function in global processes remains unclear. This pristine environment faces mounting threats from human activities, climate change, and increasing tourism.

A Novel Improvement of Feature Selection for Dynamic Hand Gesture Identification Based on Double Machine Learning.

Causal machine learning is an approach that combines causal inference and machine learning to understand and utilize causal relationships in data. In current research and applications, traditional machine learning and deep learning models always focus on prediction and pattern recognition. In contrast, causal machine learning goes a step further by revealing causal relationships between different variables.

Bioprospecting Bioactive Peptides in Body Mucus: From In Silico Insights to Essential In Vitro Validation.

Fish body mucus plays a protective role, especially in , which inhabits intertidal zones vulnerable to anthropogenic contaminants. In silico predicted bioactive peptides were identified in its body mucus, namely, EDNSELGQETPTLR (HdKTLR), DPPNPKNL (HdKNL), PAPPPPPP (HdPPP), VYPFPGPLPN (HdVLPN), and PFPGPLPN (HdLPN). These peptides were studied in vitro for bioactivities and aggregation behavior under different ionic strengths and pH values.

Feasibility and Safety of bedside placement of tunneled dialysis catheters: A systematic review and meta-analysis of prevalence.

Tunneled dialysis catheters (TDCs) are typically the vascular access of choice for critically ill patients in need of urgent dialysis for prolonged periods of time. The standard of practice is to insert these catheters under fluoroscopic guidance to ensure proper catheter placement in the cavo-atrial junction or right atrium. However, there is increasing interest in bedside placement of TDCs without fluoroscopic guidance in patients deemed too critically ill to be transported to the fluoroscopy suite or operating room.

Exploring freshwater soundscapes of tropical marshland habitats in Southeast Asia: insights into auditory sensory adaptation of wild Siamese fighting fish .

While soundscapes shape the structure and function of auditory systems over evolutionary timescales, there is limited information regarding the adaptation of wild fish populations to their natural acoustic environments. This is particularly relevant for freshwater ecosystems, which are extremely diverse and face escalating pressures from human activities and associated noise pollution. The Siamese fighting fish is one of the most important cultured species in the global ornamental fish market and is increasingly recognized as a model organism for genetics and behavioural studies.