TRAP1 and its therapeutic potential.

The mitochondrial Hsp90 isoform, Tumor Necrosis Factor Receptor Associated Protein 1 (TRAP1), is central to the pathogenesis of disease states that include cancer, ischemic retinopathy, and diabetic kidney disease among others. TRAP1 contributes to these diseases through the regulation of mitochondrial metabolism, apoptosis, oxidative stress, cell signaling and angiogenesis through interactions with client proteins. Numerous TRAP1-selective inhibitors have been developed to limit the toxicities associated with Hsp90 pan-inhibition, while leveraging the therapeutic benefits of TRAP1 inhibition.

Energy burden and asthma prevalence in U.S. cities: An emerging social determinant of health.

Background: Energy burden, defined as the inability to afford residential energy consumption, is a pressing public health issue globally and in the U.S. However, its impact on asthma remains largely unknown.

DeepPhosPPI: a deep learning framework with attention-CNN and transformer for predicting phosphorylation effects on protein-protein interactions.

Protein phosphorylation regulates protein function and cellular signaling pathways, and is strongly associated with diseases, including neurodegenerative disorders and cancer. Phosphorylation plays a critical role in regulating protein activity and cellular signaling by modulating protein-protein interactions (PPIs). It alters binding affinities and interaction networks, thereby influencing biological processes and maintaining cellular homeostasis.

The association of pre-neoadjuvant SUVmax and post-neoadjuvant change in SUVmax on FDG-PET with survival after oesophagectomy for cancer.

Background: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is currently widely used in staging and re-staging oesophageal cancer after neoadjuvant therapy. The maximal standardized uptake value (SUVmax) is a reproducible parameter that may predict survival. This study aimed to determine the prognostic significance of SUVmax and the change in SUVmax after neoadjuvant treatment (ΔSUVmax) on overall and disease-free survival.

Dispensing Patterns of Prescription Medicines Among Older Australians From 2013-2023.

Objectives: To characterize annual trends in prescription medicine dispensing patterns among Australians ≥65 years of age from 2013-2023.

Design: Population-based retrospective descriptive study.

Setting And Participants: A 10% sample of the Australian Pharmaceutical Benefits Scheme (PBS) dataset covering medicines dispensed between 2013 and 2023.

Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.

Background: The benefits of oral corticosteroid (OCS) stewardship approaches -including monoclonal antibody treatments for severe asthma- on reducing toxic OCS exposure and related comorbidities such as depression and anxiety require real-world evaluation.

Methods: This real-world observational study investigated OCS exposure and associated complications over 24 months in patients enrolled in the Australian Mepolizumab Registry (n = 412).

Results: Patients were median age 59 years, 58 % were female.

'Work while you learn': Evaluating a paid employment model for postgraduate midwifery students in diverse contexts.

Background: Postgraduate midwifery student employment models are lacking robust evaluation of how the paid employment model serves as a workforce strategy in Western Australia.

Aim: The aim of this study was to evaluate a paid employment model for postgraduate midwifery students, that was implemented in metropolitan, rural, and regional areas in a Western Australian context.

Methods: A convergent parallel design collected both quantitative and qualitative data.

AI-powered automated model construction for patient-specific CFD simulations of aortic flows.

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images.

Missouri College Students' Intentions Towards Initiating or Changing Cannabis Use in a Shifting Legal Landscape.

Background: With cannabis legal in nearly half of U.S. states, important concerns about the public health impact remain, particularly for states yet to legalize.

Reviews of Religion, Spirituality and Health.

This issue of JORH presents numerous literature reviews focusing on religious and spiritual wellbeing, a variety of lifespan health conditions, and topics relating to public health. It also presents a range of specialist research from Türkiye exploring chronic conditions, the role of nursing, the victims and survivors of earthquakes, and finally, coping with the prospect of death.

Nonlinear Associations of Depression and Stigma With Subclinical Hikikomori in Cancer Survivors.

Background: Cancer survivors often experience depression and stigma associated with chronic diseases, which may increase the risk of subclinical hikikomori.

Aims: This study examined the prevalence of subclinical hikikomori and its nonlinear associations with depression and stigma among cancer patients.

Methods: A cross-sectional survey was conducted among 1951 cancer survivors.

Bioaccumulation and Transfer of Per- and Polyfluoroalkyl Substances (PFAS) in a Stream and Riparian Food Web Contaminated by Food Processing Wastewater.

We evaluated the bioaccumulation and transfer of per- and polyfluoroalkyl substances (PFAS) in a stream food web contaminated by a food processing facility. Abiotic (i.e.

Acinetobacter baumannii as a Model for the Study and Application of Gram-Negative Outer Membrane Vesicles: A Systematic Review.

Outer membrane vesicles (OMVs) are extracellular nanostructures released from Gram-negative bacteria. Acinetobacter baumannii OMVs (AbOMVs) have been extensively studied and can thus be used as a model for understanding multiple aspects of OMV biology. In this systematic review, we comprehensively assess the relevant literature covering AbOMVs and present these studies in the context of OMV biology in general.

Changes in the retail availability of vapes through brick-and-mortar vape stores and convenience stores in Western Australia following legislative reforms.

Objective: Monitor the operational status and vape selling practices of 'brick-and-mortar' vape stores and convenience stores in Western Australia (WA) during the phasing in of the Australian federal vaping reforms in 2024.

Methods: A previous online audit identified 194 physical vape stores in WA in January 2023 (baseline). In June-September 2024, this audit was repeated to ascertain operational status and evidence of vape sales from those stores, complemented by in-person observational visits to a subset of stores and inner Perth convenience stores.

Item selection for the development and validation of a revised classification criteria for adult and juvenile idiopathic inflammatory myopathies: MyoROC project.

Objective: A revision of the 2017 EULAR-ACR myositis classification criteria, namely EULAR-ACR funded Myositis Revision of Classification (MyoROC) project, is currently underway involving a large international group of experts. In the first phase of this project, we identified additional items to be tested in the criteria.

Methods: We distributed an electronic survey to International Myositis Assessment and Clinical Studies (IMACS) members to identify new items.

Symptoms matter - symptom diversity and trajectory across different phases of heart failure: from diagnosis to end of life.

Purpose Of Review: Heart failure is a complex, progressive and life-limiting condition that affects individuals beyond physical symptoms. Psychosocial and behavioural symptoms, such as anxiety, depression, cognitive impairment, and social withdrawal, substantially impact their quality of life. Despite increasing recognition of multidimensional symptom burden across heart failure trajectory, these non-physical symptoms are often under-recognised by clinicians and researchers.

Development and initial psychometric properties of the timed upper limb assessment in older adults with Parkinson's.

Introduction: Upper limb dysfunction is common in people with Parkinson's. This study aimed to pilot and establish the initial psychometric properties of the timed upper limb assessment (TULA), a 10-item timed functional upper limb assessment tool.

Method: A prospective observational study was conducted with 381 participants (202 with Parkinson's, 179 controls).

ACR-ABS-ACNM-ARS-SIR-SNMMI Practice Parameter for Radioembolization of Liver Malignancies.

Objectives: The practice parameter was revised collaboratively by the American College of Radiology (ACR), the American Brachytherapy Society (ABS), the American College of Nuclear Medicine (ACNM), the American Radium Society (ARS), the Society of Interventional Radiology (SIR), and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). This document summarizes current evidence-based guidelines for the administration of Yttrium radioembolic therapy to the liver, including training requirements, evidence-based guidelines for administration, and safe practice for administration.

Methods: This practice parameter was revised according to the process described under the heading The Process for Developing ACR Practice Parameters and Technical Standards on the ACR website (https://www.

Shaping a knowable event or embracing a mysterious journey: A mixed methods study on palliative care clinician views on voluntary assisted dying.

Objectives: This study explored Australian palliative care clinicians' perspectives on the legalization of voluntary assisted dying (VAD), aiming to identify variables associated with clinicians' views and understand challenges of its implementation.

Methods: An online survey exploring support for legalization of VAD was sent to palliative care clinicians in Queensland and New South Wales and followed up with semi-structured interviews. Support was categorized as positive, uncertain, or negative.

Equilibrium properties of a coupled contagion model of mosquito-borne disease and mosquito preventive behaviors.

Although different strategies for mosquito-borne disease prevention can vary significantly in their efficacy and scale of implementation, they all require that individuals comply with their use. Despite this, human behavior is rarely considered in mathematical models of mosquito-borne diseases. Here, we sought to address that gap by establishing general expectations for how different behavioral stimuli and forms of mosquito prevention shape the equilibrium prevalence of disease.

Person-environment transactions of impulsive traits and day-level alcohol use: A narrative review.

Background: Person-Environment Transactions Theory purports that certain individuals react differently (and gain different experiences) based upon their environment, which therefore informs acute and long-term behavioral development. Given the central role of impulsive traits (i.e.