Analysis of congruence between nursing metaparadigm concepts and American Academy Nursing policy 2010 to 2024.

Background: Nursology (aka nursing) is the study and practice of discipline specific knowledge. The most abstract component of nursology is its metaparadigm, which is foundational to all other nursology knowledge.

Purpose: The purpose of this literature review was to identify the extent to which the metaparadigm concepts are evident in American Academy of Nursing approved journal and website articles about health policy published between 2010 and 2024.

Metabolomic profiles of an atherogenic TMAO-dietary pattern among postmenopausal women.

Purpose: We previously identified a dietary pattern (DP) associated with plasma trimethylamine -oxide (TMAO) and choline, the TMAO-DP, where higher scores represent more atherogenic potential of the diet. The mechanisms linking dietary intake to the presence of choline and TMAO in the plasma, and by which TMAO may influence atherosclerosis in humans require further clarification. The objective was to evaluate associations between the TMAO-DP and metabolomic profiles in postmenopausal women from the Women’s Health Initiative (WHI).

Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.

Background: Associations between premenopausal plasma metabolites and breast cancer incidence are largely unknown.

Methods: We conducted a prospective, matched case-control study in which we measured pre-diagnostic metabolomic profiles among predominantly premenopausal women in the Nurses' Health Study II (n = 2010). Lipids, carbohydrates, and organic acid-related metabolites (n = 218) were profiled via liquid chromatography-tandem mass spectrometry.

Secondary Infusion Underdelivery: Risks and Rewards of Common Workarounds.

Secondary medication delivery using large-volume smart pumps offers important workflow and safety benefits. However, the widely used linear peristaltic large-volume smart pumps rely on sufficient head-height differential for accurate secondary infusion, leading to underdelivery risks. This article outlines common clinician workarounds used to mitigate these risks, including delivering secondary medications via primary mode, programming excess volume to be infused, clamping primary lines, and using short-set primary delivery.

Beyond Monitors: Intravenous Smart Pump Alarm Fatigue As a Safety Concern.

Intravenous smart pump alarm fatigue remains a persistent and underrecognized patient safety concern in acute and critical care settings. Although alarm fatigue has been traditionally associated with physiological monitors, intravenous smart pumps are also a frequent source of alarms for hospitalized patients that contribute substantially to alarm fatigue. This article synthesizes current evidence on intravenous smart pumps and related alarm fatigue, identifies knowledge gaps, and proposes short-term and long-term interventions.

Optimizing Patient Safety: Intravenous Smart Pump Usability in Acute and Critical Care.

Large-volume intravenous (IV) smart pumps are used in acute and critical care to deliver IV fluids and medications with safety-enhancing features such as dose error reduction systems. Although these technologies offer improvements over manual administration, IV smart pumps are associated with high rates of medication errors, programming challenges, and usability issues. Alarm fatigue, interface complexity, and workarounds are common, with studies showing high error rates.

The role of Universal Grammar and crosslinguistic influence in the interpretation of recursive set-subset adjectives in adult Romanian L1-English L2 bilinguals.

Our research contributes to debates about the role of Universal Grammar constraints and crosslinguistic influence in sequential bilingual acquisition and use. We investigate experimentally how adult Romanian L1-English L2 bilinguals interpret sequential adjectival modifiers of a noun in recursive set-subset contexts in both languages (e.g.

Inflammatory pathways in transfusion-associated circulatory overload.

Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-associated mortality. TACO is thought to result from hydrostatic forces in the vascular space, leading to transudative pulmonary edema. Recent studies suggest that TACO is not solely a volume overload phenomenon, but may involve inflammatory processes.

The Multidimensional Assessment of Parenting Scale: Youth Report Form in Inpatient and Partial Hospital Settings.

The Multidimensional Assessment of Parenting Scale (MAPS) was developed to assess a wide range of behaviors across positive and negative domains of parenting. This study aims to expand the utility of the MAPS by evaluating a youth-report version which provides an additional perspective on parenting practices. The study evaluated the youth-report form of the MAPS (MAPS-Y) in a large clinical population ( = 628) ranging from middle childhood (8-12) to adolescence (13-17) who were admitted to partial and inpatient psychiatric units.

Comparative analysis of cranberry fruit rot fungal diversity in Massachusetts from wild, organic, and conventional ecosystems using multiplex PCR.

Cranberry fruit rot (CFR) has been a major challenge in cranberry production affecting fruit quality, particularly in Massachusetts and New Jersey. It is known to be a disease complex associated with several diverse fungi. This study provides the first comprehensive assessment of CFR fungal population dynamics across wild, organic, and conventional cranberry production systems in southeastern Massachusetts.

Single-Molecule Fluorescence Microscopy Reveals Energy Transfer Active versus Inactive Nanocrystal/Dye Conjugate Pairs.

Defect-mediated energy transfer (EnT) is a radiative process that occurs between donor defect states in the forbidden bandgap of semiconductor nanocrystals (NCs) and dye molecules bound to their surfaces. The EnT efficiency depends on the number of dye molecules attached to each NC, the donor-acceptor distance, and the dipole orientation factor between the donor and acceptor, all of which vary across individual NCs in a sample. While ensemble-level fluorescence spectroscopy measurements have provided values for donor-acceptor distances, dye-to-NC ratios, and EnT rate constants, questions remain about the impact of donor/acceptor heterogeneity on observed EnT efficiencies.

Vibrational Spectroscopy of C-H Activation Intermediates and Dehydrogenation Products of Sequential Reactions of Niobium Cation with Methane.

Vibrational spectra of NbCH ( = 1-4) and dehydrogenation products NbCH and NbCH produced by the reaction of Nb with methane are measured using photofragment spectroscopy in the C-H and H-H stretching regions (2500-3600 cm). Entrance channel complexes Nb(CH) are observed with red-shifted vibrations of proximate C-H stretches. Calculations at the B3LYP/aug-cc-pVTZ level of theory assist in identifying the structures of the ions.

Automatic Identification of Potential Cellular Metabolites for Untargeted NMR Metabolomics.

An organism's metabolic profile provides vital information pertaining to its physiology or pathology. To monitor these biochemical changes, Nuclear Magnetic Resonance (NMR) spectroscopy has found success in non-invasively observing metabolite changes within intact samples in an untargeted manner. However, biological samples are chemically complex, comprised of many different constituents (amino acids, carbohydrates, and lipids) at varying concentrations depending on physiological and pathological conditions.

Ambient air pollution during developmental windows of spermatogenesis and semen quality among an infertility treatment seeking population.

Prior studies have observed impacts of air pollution on semen quality, but timing of exposure during developmental windows of spermatogenesis and impacts of low-to-moderate air pollution is less well understood. We examined the relation between air pollution and semen quality in the Folic Acid and Zinc Supplementation Trial (2013-2018), which enrolled male partners of couples seeking infertility treatment in the Salt Lake City, Utah region (n = 2015). Semen quality parameters were assessed at baseline, 2-, 4-, and 6-months follow-up.

Role of Charge Patterning and Hydrophobicity in Peptide-Based Complex Coacervates.

Complex coacervation has emerged as a powerful model for studying the self-assembly of intrinsically disordered proteins (IDPs) in biological condensates in cells. We characterized the phase behavior and rheology of coacervates formed from peptides with regular repeating sequences to examine the effects of charge patterning and hydrophobicity on coacervate stability and material properties. Our results show that increasing the size of charged blocks enhances salt resistance via electrostatic cooperativity, while incorporating small hydrophobic segments further stabilizes coacervates and increases viscosity through hydrophobic clustering.

Intended Outcomes and Core Components of Primary Care-Based Literacy Promotion as Defined by Experts.

Objective: Primary care-based literacy promotion enhances caregiver-child shared reading and child language outcomes, yet variation in implementation may dilute its impact. This study examines expert perspectives on intended outcomes of literacy promotion, as well as its core components, those necessary to achieve intended outcomes, and components that are recommended but adaptable to context.

Methods: We purposively sampled healthcare and policy experts in primary care-based literacy promotion from the U.

Barrel expansion of outer membrane protein G nanopore through β-hairpin duplication.

Outer membrane β-barrel proteins (OMPs) are channels found in the outer membranes of Gram-negative bacteria characterized by a stable and diverse barrel architecture, which has made them attractive for nanopore sensing applications. Here, we systematically investigated the feasibility of expanding outer membrane protein G (OmpG) from its native 14-stranded β-barrel to an enhanced conductance variant by independently duplicating each of its seven hairpin units and inserting them downstream of their endogenous positions. Most combinations did not increase pore diameter, but duplication of the terminal seventh hairpin exhibited a rare population of pores with enhanced conductance, suggesting barrel enlargement.

Recent Advances in Plant-Based Emulsion Gels: Preparation, Characterization, Applications, and Future Perspectives.

Plant-based foods have emerged as a major focus of the modern food industry as it tries to create more sustainable, environmentally friendly, and healthy products. Plant-based emulsion gels (PBEGs) can be used to provide valuable structures, textures, and functions in many plant-based food applications. For instance, they can be used as a matrix to form semi-solid plant-based meat, fish, egg, or dairy analogs, delivery systems for bioactive compounds in functional foods, and edible inks in 3D food printing.

Developing an effective pretreatment process for hot-air drying of Chinese yam (Dioscorea opposita Thunb.) slices: Drying characteristics, efficiency, and quality.

This study evaluated the effects of both thermal (microwave, hot water, steam) and non-thermal (cold plasma, ultra-high pressure) pretreatments of Chinese yam. The results showed that the time of hot-air drying 70 °C was shortened by 20.83 %, 13.

HIV Testing in African American Churches: Results from the Taking It to the Pews Cluster-Randomized Trial.

To examine effects of a multilevel, religiously-tailored HIV testing intervention, Taking It to the Pews (TIPS), on receipt of HIV testing with African American church-affiliated populations, 14 African American churches (N = 1,491) were randomized to TIPS or a multilevel, non-tailored HIV education attention-control arm in a cluster-randomized trial (Kansas City urban area, 2013 to 2019). Receipt of an HIV test was examined using objective data and participant self-reports (last 12 months), including self-reported exposure to intervention components. Overall, 471 HIV tests were completed; TIPS intervention churches conducted significantly more tests than controls (339 versus 132, p = 0.

Sensitive Detection of Intercellular Tensile Forces via Cas12a-Assisted Membrane Molecular Probes.

Intercellular forces are critical for shaping cells, driving migration, and guiding tissue development and morphogenesis. However, these transient and low-intensity forces are still challenging to detect. Here, we developed a Force-Responsive Cas12a-assisted Tension Sensor (FRCTS), which leverages the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a technology to enable more reliable detection of cumulative molecular force events generated at cell-cell junctions.

Synergistic stabilization of high internal phase Pickering emulsions using zein nanoparticles and quillaja saponin: Advancing stability, functional properties, and fat replacement in food systems.

High internal phase Pickering emulsions (HIPPEs), stabilized by colloidal particles, have attracted interest owing to their exceptional stability, tunable viscoelasticity, and versatile encapsulation capabilities. With increasing health concerns over saturated fats and the demand for sustainable fat alternatives, novel emulsion-based substitutes are of significant interest. In this study, oil-in-water HIPPEs containing 80 % oil phase were formulated using food-grade zein nanoparticles (ZNPs) and quillaja saponin (QS) as co-stabilizers.

Evaluating the muscularity-oriented eating test: Factor structure and psychometric properties among university athletes and across sexes.

Objective: The Muscularity-Oriented Eating Test (MOET) was developed to measure muscularity-oriented eating pathology among young men; however, this construct is relevant across sexes and may be particularly applicable to athletes. Thus, this study sought to validate the MOET among male and female athletes and non-athletes.

Methods: Students (N = 2189) from three U.