Guidelines for the Standardization of Adult Echocardiography Reporting: Recommendations From the American Society of Echocardiography.

The American Society of Echocardiography (ASE) plays a vital role in establishing practice standards and guidelines within the echocardiography field. Its influence is comprehensive, covering training, image acquisition, nomenclature, measurements, diagnosis, and quality improvement. This report focuses on the final phases of the diagnostic imaging process, specifically reporting and communicating exam results.

Cardiopulmonary Point-of-Care Ultrasonography for Hospitalist Management of Undifferentiated Dyspnea.

Importance: The association of cardiopulmonary point-of-care ultrasonography (POCUS) with length of stay (LOS) and hospitalization costs for patients admitted to internal medicine wards remains uncertain.

Objective: To evaluate a collaborative implementation model involving hospitalists, sonographers, and a remote cardiologist for integrating cardiopulmonary POCUS into the assessment of adult patients (≥18 years) hospitalized with undifferentiated dyspnea, and to assess its association with LOS and hospitalization costs.

Design, Setting, And Participants: This quality improvement study employed a type 1 effectiveness-implementation hybrid design using a 6-month stepped-wedge cluster randomized approach, conducted at a tertiary care hospital in the US between December 7, 2023, and July 2, 2024, to compare the standard-of-care (control) with the intervention group.

Identifying latent classes of dual cigarette/ENDS users based on motivations for ENDS use: Product substitution versus complementary use.

Introduction: The aim of this study was to empirically identify subgroups of dual cigarette and ENDS product users based on their motivations for ENDS use.

Methods: Data came from n=713 adult dual cigarette/ENDS users in the Population Assessment of Tobacco and Health Wave 6 public use data file. We used latent class analysis to identify qualitatively different subgroups within the sample and applied logistic regression to assess correlates of latent class membership.

Temporal Trends in Young Adult Cannabis and Tobacco Use in States with Different Cannabis Policies.

Objective: Cannabis legalization may impact both cannabis and tobacco use, given the high prevalence of co-use (including blunt use) among young adults (YAs) in the United States. The objective of this descriptive ecological study was to examine trends in YA cannabis and tobacco use from 2002-2018 in states that passed adult and medical use (AMU) or medical use only (MUO) cannabis laws during that time ( = 16).

Method: Using data from the National Survey on Drug Use and Health, we conducted a segmented regression analysis to calculate absolute percent change in past 30-day cannabis, blunt, cigarette, and cigar use between time points.

Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.

Background: Associations between premenopausal plasma metabolites and breast cancer incidence are largely unknown.

Methods: We conducted a prospective, matched case-control study in which we measured pre-diagnostic metabolomic profiles among predominantly premenopausal women in the Nurses' Health Study II (n = 2010). Lipids, carbohydrates, and organic acid-related metabolites (n = 218) were profiled via liquid chromatography-tandem mass spectrometry.

Endometriosis and menopausal health: An EMAS clinical guide.

Introduction: Endometriosis is a common gynecological condition, and problems may persist or develop after the menopause. Endometriosis or its treatment in premenopausal women may lead to premature or early menopause. Thus, it is imperative that healthcare providers are appropriately trained in management of endometriosis at the menopause and beyond.

Cannabis vape product advertising exposure is associated with cannabis vape product use and frequency among U.S. Young adults.

Introduction: Cannabis vape products (CVPs) have gained significant popularity as a method of cannabis consumption among U.S. young adults (YAs), raising concerns about associated health risks.

State-of-the-art Neurointervention for Extended Window and Large Ischemic Core.

The implementation of endovascular therapy as a treatment for acute ischemic stroke has developed greatly in recent years. The primary trials demonstrated negative to mixed results, and it wasn't until the MR CLEAN trial that thrombectomy was established as a beneficial treatment. Since then, further studies have continued to provide additional data allowing for expansion of patient eligibility to receive such therapy.

Association of Glucagon-like Peptide-1 Receptor Agonist Use with Complications Following Thoracic and/or Lumbar Spinal Fusion for Degenerative Spine Disease: A BMI-Stratified Retrospective Study.

Study Design: Retrospective Cohort.

Summary Of Background Data: Spinal fusions are common interventions for degenerative spine disease (DSD), with increasing utilization in obese and metabolic syndrome populations. Glucagon-like peptide-1 (GLP-1) receptor agonists (RA), widely adopted for diabetes and weight management, may offer systemic benefits that exert a parallel influence on surgical outcomes.

PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.

Despite genome-wide association studies (GWAS) of late-onset Alzheimer's disease (LOAD) having identified many genetic risk loci, the underlying disease mechanisms remain largely unclear. Determining causal disease variants and their LOAD-relevant cellular phenotypes has been a challenge. Here, using our approach for identifying functional GWAS risk variants showing allele-specific open chromatin, we systematically identified putative causal LOAD-risk variants in human induced pluripotent stem (iPS)-cell-derived neurons, astrocytes and microglia, and linked a PICALM LOAD-risk allele to a microglial-specific role of PICALM in lipid droplet (LD) accumulation.

A Leg Up: Evaluating Ultramassive Transfusion after Extremity Vascular Injury.

Introduction: Extremity vascular injuries (EVI) are rare, life-threatening injuries that may require ultra-massive transfusion (UMT), defined as transfusion of ≥20 units of red cell products in 24 hours. This study aimed to evaluate outcomes of patients with EVI who required UMT and to determine which variables are associated with survival.

Methods: A retrospective, multicenter analysis from eleven high-volume trauma centers was conducted of trauma patients who received UMT from 2016-2024.

Radical nephroureterectomy vs kidney sparing surgery for upper tract urothelial carcinoma in solitary kidney patients: a multi-institutional analysis of the ROBUUST 2.0 registry.

Purpose: Radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) in solitary kidney patients is a rare and underreported scenario. This study aims to compare the outcomes of UTUC solitary kidney patients becoming anephric after RNU to those of patients undergoing kidney-sparing surgery (KSS).

Methods: Data from patients with a solitary kidney were retrieved from the ROBUUST 2.

Pre-existing YFV-17D immunity mediates T cell cross-protection against dengue virus serotype 2 infection in mice.

Widespread yellow fever virus (YFV) immunity in Sub-Saharan Africa may mitigate orthoflavivirus outbreaks. Here, we investigate whether pre-existing YFV-17D immunity confers cross-protection against dengue virus serotype 2 (DENV-2) infection in a murine model. IFNAR1 mice immunized with YFV-17D exhibited significantly reduced DENV-2 viremia, weight loss, and disease severity, with improved survival compared to naïve controls.

Clinical and Genomic Features and Prognostic Biomarkers of Oligometastatic Nonsmall Cell Lung Cancer.

Introduction: Treatment of metastatic disease is rapidly evolving with local therapies increasingly being used in patients with oligometastasis. Better personalization is needed to appropriate select patients for these interventions. We attempted to better understand clinical features and genomic features of oligometastatic nonsmall cell lung cancer (NSCLC).

Presumed Cerebral Vasculitis Following Pneumococcal Meningitis: A Rare but Life-Threatening Complication.

A 65-year-old woman presented with pneumococcal sepsis and meningitis. Despite appropriate antimicrobial therapy and intravenous (IV) dexamethasone, her mental status did not improve. Findings of brain imaging were suggestive of cerebral vasculitis.

PRIME 2.0: An Update to The Proposed Requirements for Cardiovascular Imaging-Related Machine Learning Evaluation Checklist.

The PRIME 2.0 checklist is an updated, domain-specific framework designed to standardize the development, evaluation, and reporting of artificial intelligence (AI) applications in cardiovascular imaging. This update specifically responds to rapid advances from traditional machine learning to deep learning, large language models, and multimodal generative AI.

Biceps Femoris Long Head Fascicle Length Not Associated With Hamstring Injury Risk in NCAA Football Athletes.

Objective: To determine whether biceps femoris long head (BFlh) fascicle length (FL) is related to hamstring injury (HSI) risk in collegiate football athletes.

Design: Retrospective cohort.

Setting: University athletic medical center.

Intended Outcomes and Core Components of Primary Care-Based Literacy Promotion as Defined by Experts.

Objective: Primary care-based literacy promotion enhances caregiver-child shared reading and child language outcomes, yet variation in implementation may dilute its impact. This study examines expert perspectives on intended outcomes of literacy promotion, as well as its core components, those necessary to achieve intended outcomes, and components that are recommended but adaptable to context.

Methods: We purposively sampled healthcare and policy experts in primary care-based literacy promotion from the U.

Revisiting subcallosal cingulate deep brain stimulation for depression: Long-term safety and effectiveness outcomes from a pooled analysis of 172 implanted patients.

Objective: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) has been investigated clinically for treatment-resistant depression (TRD). Although the initial BROADEN study, a randomized controlled trial, was halted after an interim futility analysis, observation of long-term follow-up (LTFU) data from this and other cohorts demonstrated sustained improvement in depressive symptoms, prompting further investigation of DBS as a therapeutic option.

Methods: Data from 5 studies, including BROADEN, were used to evaluate the long-term safety and effectiveness of SCC DBS for TRD.

Quality matters: Artificial intelligence-based assessment of feedback quality predicts technical skill improvement.

Introduction: Consistently delivering high-quality feedback is critical, yet challenging, in surgical education. We hypothesized that feedback quality, as assessed by artificial intelligence (AI, Teach1) based-tools, would correlate with improvements in technical skill acquisition during simulated paracentesis training.

Methods: Seventy-five fourth-year medical students meeting inclusion criteria (baseline Objective Structured Assessment of Technical Skills scores ≤20) performed paracentesis on simulators, received instructor feedback via a digital platform, and completed a second attempt.

Transcriptomic Profile of Perineural Invasion in Prostate Cancer Identifies Prognostic Gene Signatures.

Prostate cancer is a common malignancy among men worldwide, with various histopathologic features that influence its progression and prognosis. One such feature is perineural invasion (PNI), which has been associated with aggressive disease. In this retrospective study, we analyzed genomic alterations associated with PNI in patients who underwent radical prostatectomy.

Tricuspid valve replacement outcomes by baseline tricuspid regurgitation severity: the TRISCEND II trial.

Background And Aims: The TRISCEND II trial demonstrated superior clinical benefits for patients with ≥severe tricuspid regurgitation (TR) treated with the EVOQUE transcatheter tricuspid valve replacement (TTVR) system plus medical therapy versus medical therapy alone. This work reports 1-year and 18-month outcomes in patients stratified by baseline TR severity.

Methods: The multicentre, prospective TRISCEND II trial enrolled 400 patients with symptomatic, ≥severe TR and randomised 2:1 to TTVR (n=267) or control (n=133).

The Impact of Psychiatric Comorbidities on Outcomes and Quality of Life in Plastic Surgery: A Literature Review & Matched Analysis.

Background: Patients undergoing plastic surgery often have higher rates of psychiatric disorders, which may influence surgical outcomes and quality of life (QoL).

Methods: A retrospective review of patients with and without psychiatric comorbidities who underwent reduction mammoplasty or body contouring (panniculectomy and/or abdominoplasty) from 2016 to 2022 was conducted. Propensity-score matching considered age, BMI, ethnicity, bariatric surgery history, ptosis, and breast tissue mass.