Modifiable risk factors for lower-extremity injury: a systematic review and meta-analysis for the Female, Woman and Girl Athlete Injury Prevention (FAIR) consensus.

Objective: Examine potentially modifiable risk factors (MRFs) for female/woman/girl athletes' lower-extremity injuries.

Design: Systematic review with meta- or semiquantitative analyses and Grading of Recommendations, Assessment, Development and Evaluation.

Data Sources: MEDLINE, CINAHL, APA PsycINFO, Cochrane Systematic Review Database, CENTRAL, SPORTDiscus, EMBASE, ERIC searched 30 October or 23 November 2023.

Quality of care for people with chronic kidney disease: a systematic review and meta-analysis.

Objectives: Guideline-based strategies to prevent chronic kidney disease (CKD) progression and complications are available, yet their implementation in clinical practice is uncertain. We aimed to synthesise the available evidence on the concordance of CKD care with clinical guidelines to identify gaps and inform future CKD care.

Design: Systematic review and meta-analysis.

Patient and provider perspective with the use of a central intake system (CIS) for surgical waitlist management: a systematic review.

Objective: Our study aimed to summarise and reflect on current evidence around patient and surgeon perspectives regarding the use of a central intake system (CIS) as a strategy for managing surgical waitlists.

Search Strategy: A systematic review was conducted. Searches were performed on 9 October 2023.

Taking the Pulse: A Retrospective, Population-Based Analysis of Alberta's Privatization of Cardiac Testing.

Background: Many provinces are considering an expanded role for for-profit diagnostic imaging facilities. We describe trends over time in the use of cardiac imaging studies, a subset of diagnostic imaging, in the for-profit and publicly operated facilities in Alberta. Alberta has allowed testing in private facilities since the 1970s, with formalized guidelines released in 1998.

Reliability and Responsiveness of Endoscopic Indices for Assessing Crohn's Disease Postoperative Recurrence in the PREVENT trial.

Background And Aims: Assessing endoscopic activity is integral in the management of postoperative Crohn's disease (CD). We aimed to comprehensively characterize the reliability and responsiveness of different endoscopic instruments when used to assess postoperative CD activity.

Methods: Ileocolonoscopy videos (n=70) from the PREVENT trial were reviewed by three blinded central readers.

Timing genomic antigen loss in multiple myeloma treated with T-cell redirecting immunotherapies.

Genomic antigen loss is a recurring mechanism of resistance to chimeric antigen receptor T-cell (CAR-T) and T-cell engagers (TCE) in relapsed/refractory multiple myeloma (RRMM). Yet, it remains unclear whether these events are acquired under treatment or merely selected from pre-existing, undetectable clones. By leveraging chemotherapy mutational signatures as temporal barcodes within whole genome sequencing data, we could time genomic antigen escape in 4 out of 11 RRMM patients.

Association of patient and physician characteristics with androgen-deprivation-therapy intensification in patients with de novo hormone-sensitive metastatic prostate cancer: A population-based study.

Introduction: Treatment intensification with androgen receptor signaling inhibitors and/or chemotherapy is guideline recommended for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC). However, most patients only receive androgen deprivation therapy monotherapy. The aim was to identify physician-, patient-, and tumor-related factors associated with the receipt of treatment intensification.

Patient-Reported Symptoms and Direct Health Care Costs in Head and Neck Cancer.

Importance: Head and neck cancer (HNC) and its associated treatments are associated with substantial functional, psychological, and financial consequences. Patient-reported outcome measures (PROMs) play a crucial role in capturing the full impact of disease. Understanding how PROMs are associated with health care costs is critical for cancer care planning; however, the association of health care expenditure and PROMs is yet to be clarified.

A Meta-Analysis of Sex-Based Differences in Health Service Use for Persons Living With Dementia Between 2018 and 2020 in Four Canadian Provinces.

Background: Ensuring equitable healthcare services for persons with dementia is of utmost importance. Recent evidence points to sex-based differences in healthcare use in this population. However, available evidence is based on data from limited geographic regions and predates the COVID-19 pandemic, which is said to have further magnified disparities.

Transition of headache care from childhood to adulthood: Focusing needs, barriers, and models of care. A position paper of the IHS Child and Adolescent Committee.

Headache disorders are among the most common neurological conditions in children and adolescents, often continuing into adulthood and causing substantial personal and societal burdens. Yet, the transition from childhood to adult headache care remains under-addressed, with critical clinical practice, policy, and research gaps. This narrative review synthesizes existing evidence and expert perspectives to highlight the urgent need for structured, developmentally appropriate transition models in headache care.

The relationship of smoking and unhealthy alcohol use to HIV care retention and viral suppression: findings from a multi-site cohort study.

Objectives: Tobacco smoking and alcohol use may negatively influence HIV care, but associations have not been examined across cohorts.

Design: Multisite international collaboration of cohort studies.

Methods: People with HIV (PWH) were included from 11 cohorts; 5 North American and 6 Western European.

Ion association and hydrogen bonding in potassium dihydrogen phosphate solutions: Insights from molecular dynamics simulations.

Potassium dihydrogen phosphate (KDP) is a critical material in non-linear optics, with significant applications in electro-optical and laser technologies. Despite its importance, the solution properties of KDP remain poorly understood, and to the best of our knowledge, no prior molecular dynamics (MD) simulation studies have directly probed the structure and behavior of KDP in aqueous solutions. This study presents results from MD simulations of KDP in both solution and solid states and compares four dihydrogen phosphate (DP) force-field models in five different water models.

Investigating the Chemical-Biological Link in Extracts for the Discovery of Novel Raw Materials via and In Vitro Assays.

This study examined the impact of the extraction methods (70% ethanolic extraction, infusion) on the overall biological profile and concentration of phenolic compounds of . Infusion yielded significantly higher phenolics and flavonoids (75.73 ± 0.

Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery for Parkinson's Disease.

Background: Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) in appropriately selected patients. DBS may be underused in certain patient populations, especially women and racialized groups. Barriers and biases to receiving DBS that could account for underuse among these groups are not well studied in Canada.

Defining Sex- and Age-Specific Initial Stay Times for Continuous Heavy-Intensity Work in Hot Environments Before Heat-Mitigation Controls Are Implemented-Part B.

Rationale: Industry guidelines recommend work-rest schedules to prevent unsafe core temperature elevations (> 38.0°C or > Δ1.0°C above baseline resting) in an "average" worker exposed to occupational heat stress.

Defining Sex- and Age-Specific Initial Stay Times for Continuous Moderate-Intensity Work in Hot Environments Before Heat-Mitigation Controls Are Implemented - Part A.

Rationale: Industry guidelines recommend work-rest allocations to limit increases in core temperature (Tcore; > 38.0°C or > Δ1.0°C above resting) during work in the heat.

Predicting long-term neurodevelopmental outcomes for children born very preterm: a systematic review.

Context: Children born very preterm (<32 weeks' gestation) have increased risk of neurodevelopmental difficulties compared with those born at term. While various neonatal exposures have been linked with later developmental challenges, identifying those at risk of difficulties later in childhood remains a challenge but is essential for targeting early intervention and counselling families.

Objective: To systematically review and synthesise the evidence regarding early medical and environmental factors for neurodevelopmental impairment, cognitive, motor and behavioural outcomes for children born very preterm.

Improving the reporting on health equity in observational research (STROBE-Equity): extension checklist and elaboration.

Data on health equity to inform societally relevant evidence based decisions and policy making are lacking in the research literature. Observational studies have the potential to provide data on health equity. Yet, guidance on how to report health equity data and considerations in observational research is inadequate.

Can Step-Based Metrics Predict Current and Future Health-Related Fitness and Patient-Reported Outcomes among Women Diagnosed with Breast Cancer?

Purpose: Wearable sensors that track physical activity in daily life may offer insights that help healthcare providers optimize care plans for individuals with cancer. Therefore, we examined the links between lower health-related fitness and worse patient-reported health and various step-based metrics.

Methods: The Alberta Moving Beyond Breast Cancer Study enrolled 1,528 women recently diagnosed with breast cancer and measured health-related fitness and patient-reported health outcomes near diagnosis, and one year later.

Head Acceleration Events Sustained During High School Wrestling Matches: Grappling With Differences Between Male and Female Adolescents.

Wrestling is a popular high school sport despite high injury and concussion rates. Instrumented mouthguards can reliably measure head acceleration events (HAEs) accrued by wrestlers and may highlight potential sex differences; important considering the higher concussion rates among female athletes. The purpose of this study was to measure HAEs accrued in high school wrestling matches and compare frequency, magnitude, and head impact location between female and male wrestlers.

Effect of Time from Injury to Surgery on Surgical Technique and Complication Rate in Distal Biceps Tendon Repair.

Background: Surgical treatment options for distal biceps tendon ruptures vary based on time from injury to surgery. While direct repair (DR) is preferred for acute injuries, high flexion angle repair (HFA) and allograft reconstruction (AR) are alternatives for chronic cases. This study examines the relationship between time to surgery, surgical technique selection, and complication rates.

Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy.

Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of ∼1 in 35,000 live births, it is the most common form of syndromic clefting. Most VWS is attributed to variants in IRF6 (∼70%) or GRHL3 (∼5%), leaving up to 25% of individuals without a molecular diagnosis.