Down-Like Aerogel Flowers for Thermal Insulation Filling.

The application of aerogels in textiles is limited because their poor moisture permeability and mechanical properties. Aerogel flowers with down-like structures for clothing filling are prepared by laser cutting bacterial cellulose. The nanoporous structures of the aerogels maintained excellent heat preservation performance, and the large pores between flowers provided a channel for water vapor transmission.

Patient-Reported Symptoms and Direct Health Care Costs in Head and Neck Cancer.

Importance: Head and neck cancer (HNC) and its associated treatments are associated with substantial functional, psychological, and financial consequences. Patient-reported outcome measures (PROMs) play a crucial role in capturing the full impact of disease. Understanding how PROMs are associated with health care costs is critical for cancer care planning; however, the association of health care expenditure and PROMs is yet to be clarified.

Traditional Wisdom for Modern Sustainability: A Dish-Level Analysis of Japanese Home Cooking in NHK Today's Cooking.

Background: Balancing nutrition security with environmental sustainability is a key priority in global food policy, with Sustainable Healthy Diets (SHDs) serving as a critical framework aligned with the UN Sustainable Development Goals (SDGs). Traditional Japanese cuisine reflects SHD principles through its emphasis on plant-based, seasonal, and minimally processed dishes. However, modern, globalized dietary patterns increasingly feature ultra-processed foods, raising concerns about health risks such as high sodium intake.

COVID-related delays in non-urgent adult surgeries: comparing population-based results from two Canadian provinces.

Background: During the COVID-19 pandemic, non-urgent surgeries were delayed in order to increase the capacity to care for patients with COVID-19. To shed light on the effect of pandemic-related surgical ramp down on the quality of surgical care, this study compared Ontario with Alberta on (1) changes in the proportion of completion and wait time of surgeries with decision-to-treat in a pre-pandemic period compared to those with decision-to-treat in each of the four COVID-19 waves and (2) shifts in healthcare utilization and safety of surgical patients for the same time periods.

Methods: A retrospective population-based cohort study was conducted in Ontario on scheduled non-urgent surgeries among adults with decision-to-treat (index dates) between January 1, 2018 and December 31, 2021.

Multiomics Reveals Nonphagocytosable Microplastics Induce Colon Inflammatory Injury via Bile Acid-Gut Microbiota Interactions and Barrier Dysfunction.

Microplastics (MPs), as emerging global environmental pollutants, exhibit intestinal toxicity mechanisms that are closely associated with the particle size. Nonphagocytosable MPs (NPMs), though incapable of being internalized by intestinal epithelial cells, still provoke colonic inflammatory damage. However, the exact mechanisms remain elusive.

A Strategy to Induce Calcium Ion Storm in Cancer Stem Cells for Efficient Cancer Therapy.

Currently, tumor treatment strategies centered on Ca homeostasis imbalance primarily target mature tumor cells while neglecting the eradication of cancer stem cells (CSCs), which results in the long-standing unresolved challenge of tumor relapse in later stages of treatment. To tackle the challenge, a calcium peroxide nanoparticle (CPN)-based strategy aimed at inducing an intracellular calcium ion storm in CSCs for efficient cancer therapy was proposed in this study. Typically, hyaluronic acid (HA)-stabilized hollow mesoporous calcium peroxide nanoparticles (HMCPN@HA4) were synthesized via a facile hydrolysis-precipitation method.

Patients With Head and Neck Cancer and High Health Care Costs: A Population-Based Study.

Importance: The care for a small subset of patients is responsible for a disproportionately large share of health care expenditures. Head and neck cancer is associated with significant health care costs due to complex treatment regimens and long-term sequelae. Given this high baseline cost, identifying patients with high care costs within a population with cancer might help inform interventions to optimize resource allocation.

Molecular mechanism differences between nanoplastics and microplastics in colon toxicity: nanoplastics induce ferroptosis-mediated immunogenic cell death, while microplastics cause cell metabolic reprogramming.

Unlabelled: This study investigates the size-dependent mechanisms by which polystyrene (PS) microplastics (MPs) cause intestinal epithelial injury, focusing on the differential effects of nanoscale (100 nm) and microscale (10 μm) particles. Using both cellular and animal models, we found that 100 nm MPs are internalized by intestinal epithelial cells via endocytosis, triggering oxidative stress and ferroptosis, while 10 μm MPs primarily induce epithelial damage through mechanical disruption and metabolic reprogramming. Proteomic analyses revealed that small MPs significantly upregulate ferroptosis-related genes, including Fosl1 and components of the p53 pathway.

A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage.

Dengue virus (DENV) infection remains a critical global health threat, with DENV-2 being the most virulent serotype capable of causing lethal dengue hemorrhagic fever (DHF), a severe complication characterized by plasma leakage and hemorrhagic manifestations. While the search for viral receptors and immunocompetent animal models has persisted since the first recorded outbreak in 1779, significant gaps remain. Here, we establish the first immunocompetent murine model of DHF with intact innate/adaptive immunity by generating hTim4-transgenic C57BL/6J mice.

The Evolving Global Burden of Young-Onset Parkinson's Disease (1990-2021): Regional, Gender, and Age Disparities in the Context of Rising Incidence and Declining Mortality.

Background: Young-onset Parkinson's disease (YOPD) has emerged as a significant global public health challenge characterized by its early onset among individuals in their prime working years, complex disruptions to social roles, and a substantial socioeconomic burden encompassing diminished productivity, escalating healthcare costs, and markedly reduced quality of life.

Methods: Using Global Burden of Disease (GBD) 2021 data, this study analyzed YOPD burden (ages 20-49) from 1990 to 2021, assessing age-standardized incidence rate (ASIR), mortality rate (ASMR), disability-adjusted life years rate (ASDR), and trends via Bayesian Age-Period Cohort (BAPC) modeling.

Results: Over the past three decades, the ASIR (estimated annual percentage change [EAPC] = 1.

The influence of embodied cognition on the perception and representation of numbers: A meta-analysis.

The impact of embodiment on numerical cognition remains under debate, with varying interpretations of its role in numerical processing. To clarify the overall effect size of embodied numerosity and its influencing factors, this study conducted a meta-analysis of 73 effect sizes from 49 papers using a random effects model. The main effect revealed a medium-strength effect size of embodied cognition on number processing, g = 0.

Multi-pronged analysis of pediatric low-grade glioma and ganglioglioma reveals a unique tumor microenvironment associated with BRAF alterations.

Pediatric low-grade gliomas (pLGG) comprise 35% of all brain tumors. Despite favorable survival, patients experience significant morbidity from disease and treatments. A deeper understanding of pLGG biology is essential to identify novel, more effective, and less toxic therapies.

Theoretically improved biodegradability of fluoroquinolones in sewage and sludge.

Fluoroquinolones (FQs), recognized for their potent antibacterial activity, have been extensively used in clinical and veterinary medicine. However, their low removal efficiency during sewage treatment and the emergence of drug resistance have raised significant concerns. In this study, a molecular "design-screening-validation-mechanism analysis" approach was developed to design FQ alternatives with improved removal efficiency and reduced drug resistance.

Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid.

Background: Intermittent fasting (IF), particularly time-restricted feeding (TRF), is increasingly popular has gained popularity for weight loss, yet management, but its effects impact on gut health remain unclear. Remains inadequately understood. This study explores how investigated the effects of TRF effects on intestinal health and explored the underlying mechanisms.

PMJDM: a multi-task joint detection model for plant disease identification.

Introduction: Plant disease detection is critical for ensuring agricultural productivity, yet traditional methods often suffer from inefficiencies and inaccuracies due to manual processes and limited adaptability.

Methods: This paper presents the PlantDisease Multi-task Joint Detection Model (PMJDM), which integrates an enhanced ConvNeXt-based shared feature extraction, a texture-augmented N-RPN module with HOG/LBP metrics, multi-task branches for simultaneous plant species classification and disease detection, and CRF-based post-processing for spatial consistency. A dynamic weight adjustment mechanism is also employed to optimize task balance and improve robustness.

Cumulative temporal association between assisted reproductive technology and childhood cancer: a systematic review and meta-analysis of observational studies.

Objective: Assisted reproductive technology (ART) has contributed to the birth of over 10 million children worldwide; however, its long-term health impacts, especially the potential risk of childhood cancer, continue to be a subject of debate. This study aims to examine the most current risk associations between ART and childhood cancer.

Methods: We conducted a comprehensive search across PubMed, Embase, Web of Science, and Cochrane Library databases up to August 1, 2024.

Haemoglobin glycation index and in-hospital mortality after acute myocardial infarction in patients with/without diabetes: A prospective, nationwide and multicentre registry.

Aims: To assess the prognostic value of haemoglobin glycation index (HGI) for in-hospital mortality in acute myocardial infarction (AMI) patients with varied glucose metabolism status.

Materials And Methods: A total of 5308 AMI patients were evaluated. HGI was calculated as the measured glycated haemoglobin A1c (HbA1c) minus the predicted HbA1c.

ATDMNet: Multi-Head Agent Attention and Top-k Dynamic Mask for Camouflaged Object Detection.

Camouflaged object detection (COD) encounters substantial difficulties owing to the visual resemblance between targets and their environments, together with discrepancies in multiscale representation of features. Current methodologies confront obstacles with feature distraction, modeling far-reaching dependencies, fusing multiple-scale details, and extracting boundary specifics. Consequently, we propose ATDMNet, an amalgamated architecture combining CNN and transformer within a numerous phases feature extraction framework.

Brain Tumour Segmentation and Grading Using Local and Global Context-Aggregated Attention Network Architecture.

Brain tumours (BTs) are among the most dangerous and life-threatening cancers in humans of all ages, and the early detection of BTs can make a huge difference to their treatment. However, grade recognition is a challenging issue for radiologists involved in automated diagnosis and healthcare monitoring. Recent research has been motivated by the search for deep learning-based mechanisms for segmentation and grading to assist radiologists in diagnostic analysis.

Analysis of the Coupled Coordination of Digital Economy and Public Health Services in China and Its Influencing Factors.

Background: The coordinated development of the digital economy and public health services is essential for integrating the "Digital China" and "Healthy China" strategies and accelerating the modernization of the public health system. However, substantial regional disparities persist, necessitating a systematic evaluation of the coupling and coordination between these two domains, along with the identification of key influencing factors to support evidence-based policymaking.

Methods: This study utilizes panel data from 30 Chinese provinces spanning 2012-2021.

Coupled coordination relationship and enhancement path between digital economy and essential public health services in China.

Introduction: The coordinated development of the digital economy and essential public health services is a critical issue for advancing the Healthy China initiative and promoting health equity. However, existing policy frameworks exhibit significant shortcomings in the design of cross-system collaborative governance tools and regional adaptability, thereby constraining the implementation effectiveness of the "digital health" strategy.

Methods: This study constructs an evaluation index system for the digital economy and essential public health services based on panel data from 30 Chinese provinces from 2012 to 2021.

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay.

The phenotypic impact of nonsense variants is determined by nonsense-mediated mRNA decay (NMD), which degrades transcripts with premature termination codons (PTCs). Despite the clinical importance of nonsense variants, transcript-specific and context-dependent variations in NMD activity remain poorly understood. Here, we show that the amino acid preceding the PTC strongly influences NMD activity.

Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology.

The incidence of Gastric cancer (GC) has shown a sharp upward trend, and patients with GC complicated by diabetes exhibit significantly worse clinical outcomes and prognosis compared to those without diabetes. Traditional Chinese medicine has played a crucial role in the treatment of both GC and diabetes. Currently, Banzhilian(Scutellaria barbata D.

Co-occurrence patterns and related risk factors of ischaemic heart disease and ischaemic stroke across 203 countries and territories: a spatial correspondence and systematic analysis.

Background: Ischaemic heart disease (IHD) and ischaemic stroke are leading causes of death worldwide. Although extensively studied, previous research has predominantly addressed these two diseases in isolation. Comorbidity research faces challenges both at the patient level and in terms of study methods.

Pest detection in dynamic environments: an adaptive continual test-time domain adaptation strategy.

Pest management is essential for agricultural production and food security, as pests can cause significant crop losses and economic impact. Early pest detection is key to timely intervention. While object detection models perform well on various datasets, they assume i.