The Effectiveness and Profitability of Different Antithrombotic Therapy Regimens in Patients with Type 2 Diabetes Mellitus During 1 Year of Follow-Up after an Exacerbation of Coronary Heart Disease According to the Study ORACLE II.

Aim    To analyze the efficacy and cost-effectiveness of various options of antithrombotic therapy in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS), based on the results of a one-year follow-up.Material and methods    The article presents features of various antithrombotic therapies in patients with T2DM after ACS from the standpoint of efficacy and cost-effectiveness in real clinical practice based on the materials of the ORACLE II open prospective observational study (2014-2017). The data of 368 patients were divided into three groups based on the selected antithrombotic therapy.

Coexistence of acid sphingomyelinase deficiency type A/B and Arnold-Chiari malformation: a novel case report.

Background: Acid sphingomyelinase deficiency (ASMD) type A/B, a rare lysosomal storage disorder caused by biallelic mutations in the SMPD1 gene, presents with variable visceral and neurological manifestations. Arnold-Chiari malformation is a structural defect of the cerebellum and brainstem with distinct pathogenesis and clinical course. To our knowledge, the coexistence of these two conditions has not been previously reported.

Reciprocated tachycardias in cardiac laminopathy: a clinical case report.

Background: Cardiac laminopathies, associated with mutations in the LMNA gene, are a rare inherited disorder characterized by a broad range of clinical manifestations. There are currently no data on the association between supraventricular re-entrant tachycardias and LMNA-related cardiomyopathy.

Case Summary: A 26-year-old male presented with either wide-QRS tachycardia with a left bundle branch block (LBBB) pattern or narrow QRS tachycardia, as well as a history of palpitations since age 15.

Exploring allosteric properties of mammalian ALOX15: octyl (-(4-(benzofuran-2-yl)-2-methoxyphenyl)sulfamoyl)- and octyl (-(4-(1-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates as ALOX inhibitors.

Mammalian ALOX15 are allosteric enzymes but the mechanism of allosteric regulation remains a matter of discussion. Octyl (-(5-(1-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate inhibits the linoleate oxygenase activity of ALOX15 at nanomolar concentrations, but oxygenation of arachidonic acid is hardly affected. The mechanism of substrate selective inhibition suggests inter-monomer communication within the allosteric ALOX15 dimer complex, in which the inhibitor binding to monomer A induces conformational alterations in the structure of the active site of monomer B.

Changes in potential pathogenicity-associated proteins of upon infection of macrophage cells.

Introduction: is a spiral-shaped Gram-negative, enterohepatic bacterium classified as a conditional pathogen (pathogenicity group 2). It is known to cause bacteremia and a variety of other diseases in humans. In particular, has been shown to impair intracellular cholesterol metabolism when interacting with macrophages, leading to foam cell formation.

Dialogical Structure of the Brain and the Ternary System of the Mind: The Neurosemiotics of Yuri Lotman.

Yuri Lotman (1922-1993) was a semiologist, literary critic, and cultural historian from Soviet Russia. He is credited with founding the multidisciplinary Tartu-Moscow School of Semiotics. As a cultural theorist and humanist, he was highly influential across many fields, but his contributions to theories about the brain as a semiotic system have often been overlooked.

Prevalence and penetrance of pathogenic and likely pathogenic and gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease.

Background: Familial hypercholesterolemia (FH) is a prevalent hereditary disorder, with its monogenic form linked to an elevated risk of early-onset ischemic heart disease. Evaluating the prevalence and penetrance of pathogenic and likely pathogenic variants associated with this disorder would provide valuable information supporting routine FH screening of the general population. Such informed screening would facilitate early identification of at-risk individuals, enabling timely intervention and management.

The Role of Threats in the Support of System-Justifying Beliefs.

Background: Encounters with threats can lead to a motivation to justify the existing social system, which can be expressed through endorsement of system-justifying beliefs.

Objective: The aim of the study was to examine how difierent types of threats contribute to endorsement of system-justifying beliefs in the economic domain.

Design: We tested a theoretical model ( = 577) with internal threats (fear of death), economic threats (threats of poverty and socio-economic inequality), and subjective threat perception (belief in a dangerous and competitive world) as predictors; system-justifying beliefs (economic system justification, opposition to equality, dominance, and antiegalitarianism) served as dependent variables, and sociodemographic characteristics were included as control variables.

Bridging the gap: the impact of parental education and child leisure activities on cognitive and socioemotional skills in preschoolers.

Family socioeconomic status is broadly acknowledged to be associated with child development and wellbeing. However, the extent of this association across various dimensions of child development remains a topic of ongoing debate. This study aims to investigate the relationship between parental education and child cognitive and socioemotional skills, as well as the mediating role of children's leisure time activities, including screen time and shared book reading.

[3 + 2] Cycloaddition of thioformylium methylide with various arylidene-azolones in the synthesis of 7-thia-3-azaspiro[4.4]nonan-4-ones.

Thioformylium methylide, which is readily generated from chloromethyl(trimethylsilyl)methyl sulfide by the action of fluoride, is used for the synthesis of spirocyclic derivatives from arylidene-azolones. Four types of the corresponding heterocycles have been studied. A series of 7-thia-3-azaspiro[4.

Influence of the cation in hypophosphite-mediated catalyst-free reductive amination.

Reducing agents with phosphorus-hydrogen bond, such as sodium hypophosphite, phosphite, and hypophosphorous acid are commercially available in bulk amounts, however, their usage is understudied in organic processes. While NaHPO has proved to be an efficient four-electron reductant in the catalyst-free reductive amination, the influence of cation in hypophosphite salt has not been studied yet. This issue is a fundamentally important factor.

Neuronal ceroid lipofuscinosis type 5 in Russia: first case report and literature review.

Neuronal ceroid lipofuscinosis (NCL) is one of the most common causes of childhood dementia. NCL type 5 is characterized by epileptic seizures, cognitive decline, and progressive vision loss. Whole exome sequencing was performed, and the identified variant was confirmed by Sanger sequencing.

Updated Trends in Valvular Heart Disease-Related Heart Failure in G20-the Group of Twenty Countries: Insights From the Global Burden of Disease Study 2021.

Background: Valvular heart disease (VHD), including both non-rheumatic valvular heart disease (NRVHD) and rheumatic valvular heart disease (RVHD), is a major global health concern. Moreover, the progression of VHD to heart failure (HF) poses substantial clinical and public health challenges. In light of the global population aging, alongside increasing cardiovascular risk factors, and the additional strain imposed by the COVID-19 pandemic, a timely reassessment of the VHD-related HF burden is urgently needed.

Influence of lactulose as a composition of organic-mineral feed additive on broiler chicken productivity, feed digestibility, and microbiome.

Background And Aim: The global demand for efficient poultry production necessitates alternatives to antibiotic growth promoters. This study aimed to evaluate the effects of a novel four-component organic-mineral feed additive (OMFA), comprising lactulose, arginine, ultrafine silicon dioxide particles, and succinic acid, and a three-component variant (without lactulose) on growth performance, nutrient digestibility, elemental tissue composition, and the cecal microbiota of Arbor Acres broiler chickens.

Materials And Methods: One hundred and five one-day-old broiler chicks were randomly allocated into three groups: Control, Group I (four-component OMFA), and Group II (three-component OMFA).

Corrigendum to "method for assessing the content of molybdenum enzymes in the internal organs of fish" [MethodsX Volume 12 (2024) 1-9/102576].

[This corrects the article DOI: 10.1016/j.mex.

Room-temperature negative differential resistance in single-atom devices.

We report the observation of negative differential resistance (NDR) in single-atom single-electron devices based on arsenic, phosphorus and potassium dopants implanted in a silicon host matrix. All devices exhibit NDR, with the potassium-based one exhibiting NDR at room temperature because of the larger charging and confinement energies. Our experimental results are reproduced with a simple model that assumes sequential electron tunnelling through two series-connected charge centres, each having two discrete energy levels.

The magneto-structural correlations of ferric and ferrous neutral complexes with the pyruvic acid thiosemicarbazone ligand.

Neutral iron(III) and iron(II) complexes based on the pyruvic acid thiosemicarbazone (Hthpy) ligand [Fe(Hthpy)(thpy)] (1) and [Fe(Hthpy)] (2) were synthesized, and deeper insights into magneto-structural correlation were gained by FT-IR spectroscopy, single crystal X-ray crystallography, dc magnetic characterization, Fe Mössbauer spectroscopy, and DFT calculations. The X-ray structures of complex 1 were established for the HS ( = 5/2) state at 295 K and the LS ( = 1/2) state at 150 K. The crystal packing of 1 at these temperatures corresponds to the triclinic 1̄ symmetry and contains pairs of [Fe(Hthpy)(thpy)] complexes interconnected by a shortened S⋯S contact.

Predicting Grade and Patient Survival in Renal Cancer Using Machine Learning Analysis of Nucleolar Prominence.

Background: Patients with clear cell renal cell carcinoma (ccRCC) often undergo organ resection, with treatment strategies based on recurrence risk. Current metastatic potential assessments rely on the WHO/ISUP grading system, which is subject to interobserver variability.

Methods: We developed an artificial intelligence (AI) model to classify cells according to contemporary grading rules and evaluated the prognostic significance of tumor cell profiles, particularly focusing on cells with prominent nucleoli.

Autofluorescence Flow Cytometry for Macrophages Analysis: Polarization, Stress Conditions, and Atherosclerosis Model.

Macrophages (MΦs) are integral cellular components responsible for immune response and tissue homeostasis. Evaluation of their pro-inflammatory (M1) and anti-inflammatory (M2) polarization states, along with their metabolic profiles, typically conducted via flow cytometry, is crucial for assessing the immune status of an organism. Traditional flow cytometry relies on extrinsic fluorescent labels, which may interfere with cellular function.

Machine learning-based assessment of land use change effects on land surface temperature fluctuations in Ho Chi Minh city, Vietnam.

Sustainable urban development requires actionable insights into the thermal consequences of land transformation. This study examines the impact of land use and land cover (LULC) changes on land surface temperature (LST) in Ho Chi Minh city, Vietnam, between 1998 and 2024. Using Google Earth Engine (GEE), three machine learning algorithms-random forest (RF), support vector machine (SVM), and classification and regression tree (CART)-were applied for LULC classification.

Chromosomal puzzle in snakes: adjacent interstitial telomeric sites on chromosome 5 in three species of genus Vipera.

Large interstitial telomeric regions are considered remnants and markers of chromosomal rearrangements or a result of several suggested molecular mechanisms of telomere repeats accumulation. More rare are cases when large interstitial repeats are found not close to, but at a distance from the centromere. However, synapsis, recombination, and effects on chromatin near these regions during meiotic prophase I have not been sufficiently studied.

Gleaning from Diaries in Long-Duration Isolation.

Introduction: A 264-d isolation simulation, SFINCSS-99, was conducted in Moscow to replicate typical scenarios on an orbital space station. One long-term group of four Russian crewmembers occupied the isolation complex for most of the duration (240 d), while two international groups of four each spent 110 d successively at the complex. Additionally, there were several short visits by medical personnel.

Preparation, characterization, and application of a novel chestnut starch-based bigel as a fat substitute in bread.

This study developed a novel self-assembled bigel by combining a chestnut starch (CS) hydrogel with a γ-oryzanol/β-sitosterol (γ-ORY/β-SIT) oleogel. The influence of the hydrogel to oleogel ratio on the macro and micro structures, mechanical properties and thermal stability of the bigels was examined, and its potential as a healthier solid fat substitute was further explored. The results indicated that as the proportion of hydrogel increased (10 %-50 %), all bigels maintained a consistent semi-solid structure without any phase separation.

The role of surface material properties on the behavior of ionic liquids in nanoconfinement: A critical review and perspective of theory and simulations.

Room temperature ionic liquids show great promise as electrolytes in various technological applications, such as energy storage or electrotunable lubrication. These applications are particularly intriguing due to the specific behavior of ionic liquids in nanoconfinement. While previous research has been focused on optimizing the required characteristics through the selection of electrolyte properties, the contribution of confining material properties in these systems has been largely overlooked.