Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

Foliar Application of SiO Nanoparticles Altered Rhizosphere Metabolite and Microbe Profiles: Surface Chemistry-Driven Biological Effects.

Silica nanoparticles (SiONPs), as emerging foliar nanofertilizers, demonstrate promising potential in agriculture. However, whether foliar application of SiONPs alters belowground soil metabolites and microbe composition and abundance remains largely unknown. In this study, 3-week-old cucumber plants were foliar-sprayed with fumed or Stöber SiO NPs dosing at -4 mg of NPs per plant for 5 days.

Behavioral self-control and glycemic levels in youth with type 1 diabetes: serial mediation by family conflict and self-management behaviors.

Aims: Examine the mediating roles of family conflict (FC) and diabetes self-management behaviors (SMB) in the relationship between behavioral self-control (BSC) and glycemic levels in adolescents with type 1 diabetes (T1D). We predicted that BSC would improve glycemic levels directly and indirectly by decreasing FC and increasing SMB, both cross-sectionally and longitudinally.

Methods: 172 adolescents (M age = 16 years) with T1D were followed for three years at three medical centers.

Lie symmetry approach to the dynamical behavior and conservation laws of actin filament electrical models.

This research explores the dynamical properties and solutions of actin filaments, which serve as electrical conduits for ion transport along their lengths. Utilizing the Lie symmetry approach, we identify symmetry reductions that simplify the governing equation by lowering its dimensionality. This process leads to the formulation of a second-order differential equation, which, upon applying a Galilean transformation, is further converted into a system of first-order differential equations.

Advancing HIV Treatment Through Nanoparticles: A Precision Medicine Approach.

The poor solubility and bioavailability of antiretroviral drugs complicate the manage-ment of Human Immunodeficiency virus. The efficacy of these medications is diminished due to restricted absorption in the gastrointestinal tract. Patients often exhibit a wide range of reactions attributable to fluctuations in blood drug concentrations.

Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies.

Cancer continues to be a major global health challenge, necessitating the ongoing development of novel small-molecule therapeutics that can selectively target DNA and disrupt cancer cell proliferation. In this study we report the synthesis and characterization of novel guanidine derivatives (7a-j). Their DNA-binding potential was assessed through electronic absorption spectroscopy, revealing characteristic hypochromic shifts indicative of minor groove-binding interactions with salmon sperm DNA (SS-DNA).

Protein networks: integrating pathways for plant heat stress adaptation.

Plants' immobility renders them highly vulnerable to heat stress, which disrupts water relations, photosynthesis, respiration, and cellular homeostasis, ultimately reducing growth and yield. To survive, plants deploy a multifaceted heat stress response (HSR) that integrates calcium signaling, molecular chaperones, antioxidant enzymes, and phytohormonal networks. This review synthesizes recent advances in understanding the molecular crosstalk between phytohormones and protein synthesis during plant heat stress responses, with a particular focus on two key HSR modules: protein synthesis pathways, especially heat shock proteins (HSPs), and phytohormone signaling networks involving abscisic acid, cytokinins, ethylene, salicylic acid, and jasmonic acid.

Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis.

Tuberculosis (TB), caused by (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months.

Intimate Partner Violence and Postpartum Depression Among Pakistani Women: Moderating Role of Miscarriages.

Postpartum Depression (PPD) is a prevalent mental health concern affecting women worldwide with detrimental effects on both mothers' well-being and infants' development. In Pakistan, new mothers are at a heightened risk of PPD due to the limited availability of psychological assistance and the tabooed status of mental health in society. Intimate Partner Violence (IPV) is widely recognized as a substantial risk factor for PPD.

Preliminary Detection of Bats-associated Influenza A virus from Pakistan.

The emergence of zoonotic infections in humans is intensifying the need for awareness of the viruses circulating in animals that can cross the species barrier. Among these are the group of influenza viruses causing seasonal outbreaks and epidemics in humans and animals. As compared to the familiar human and avian influenza viruses, bat influenza viruses are relatively unknown.

Penicillium citrinum-infused Biochar and externally applied auxin enhances drought tolerance and growth of Solanum lycopersicum L. by modulating physiological, biochemical and antioxidant properties.

Drought stress is a critical issue in agricultural crops as it can affect crop development, growth, physiological processes and yield. To meet nutritional needs amid rapidly dwindling water resources, it is crucial to adopt precise and efficient strategies through various amendments. Organic treatments such as biochar and the growth hormone auxin (IAA) can play a vital role in this regard.

Bi-Allelic DSG1 Splice-Site Variant Identified in a Family With Non-Syndromic Striate Palmoplantar Keratoderma.

Hereditary palmoplantar keratoderma (PPK) involves hyperkeratosis of the palmoplantar skin and belongs to the palmoplantar epidermal differentiation disorders (pEDDs). One causal gene is Desmoglein 1 (DSG1), which encodes a protein crucial for epidermal integrity. Monoallelic DSG1 variants cause mild, non-syndromic PPK, whereas bi-allelic DSG1 variants typically cause syndromic PPK with severe additional clinical features (SAM syndrome).

Identification of a Novel GRM1 Frameshift Variant in Two Pakistani Families Broadens the Genetic Landscape of Ultra-Rare Spinocerebellar Ataxia Type 13.

Autosomal recessive spinocerebellar ataxia 13 (SCAR13) is an extremely rare neurodegenerative disorder characterized by psychomotor delay, ranging from mild to severe intellectual disability with absent or poor speech development, nystagmus and stance ataxia. If ambulation is achieved, affected subjects often exhibit gait ataxia. Additionally, epilepsy and polyneuropathy have been reported in some patients.

The shifting dynamics of plant and mushroom foraging in Kashmir.

Background: In the mountainous region of Kashmir, wild food plants (WFPs) are vital to traditional food systems and security. Ethnic communities possess rich foraging practices; however, current sociocultural and environmental impacts may affect the transmission of local plant knowledge among younger generations. This study explores traditional foraging practices and provides a cross-cultural analysis of five groups: Gujjar, Bakarwal, Lone, Syed, and Mughal.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Computer-Aided Algorithmic Approaches to Drug Development for Multi-Mutant HIV-1 Reverse Transcriptase.

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit the activity of the reverse transcriptase enzyme in HIV, representing a significant advancement in antiviral therapy. The emergence of antiviral-resistant strains of HIV-1 poses a substantial challenge in the treatment of HIV. This study presents an innovative virtual screening method that integrates a drug screening approach based on molecular structure to identify potential inhibitors for drug-resistant HIV-1 strains.

Translation and Psychometric Validation of Brief Illness Perception Questionnaire: The Urdu Version for Facilitating Multidisciplinary Research in Pakistan.

Purpose: We aimed to examine and establish the psychometric properties of the Urdu version of the Brief Illness Perception Questionnaire (BIPQ) in patients with Type 2 Diabetes Mellitus.

Methods: A standard forward-backwards translation procedure was adopted. The Urdu (lingua franca of Pakistan) version of BIPQ was approved by an independent expert panel and committee review.

An integrated bioinformatics approach for identification of key modulators and biomarkers involved in atrial fibrillation.

Introduction: Atrial fibrillation (AFib) is a sustained form of cardiac arrythmia that occurs due to sympathetic overdrive, neurohumoral and electrophysiological changes. Sympatho-renal modulatory approach via miRNA-based therapeutics is likely to be an important treatment option for AFib. The study was aimed to unravel the common miRNAs as therapeutic targets involved in sympatho- renovascular axis to combat AFib.

Hydrothermal synthesis of FeO-AgO nanocomposites supported on pristine, N/S doped graphene oxide for photocatalytic and biological applications.

Addressing the dual challenges of industrial contamination in wastewater and antimicrobial resistance is crucial for environmental preservation and global health, aligning with sustainable development goals. This study investigated the biological and photocatalytic potential of pure bimetal oxides, nanocomposites (NCs) and their counterparts incorporating graphene oxide (GO) and nitrogen- and sulfur-doped GO. A set of samples, namely FeO-AgO, FeO-AgO@GO, FeO-AgO@N-GO, and FeO-AgO@S-GO NCs, was synthesized using the hydrothermal method.

Molecular insights into PARP1 activation: structural dynamics of DNA, NAD+, and zinc‑mediated allosteric regulation.

PARP1 serves as a crucial protein for preserving genomic stability, especially in BRCA1/2-mutant cancers that lack homologous recombination repair. In response to DNA breaks, PARP1 triggers an allosteric response that communicates to its catalytic domain, initiating the synthesis of poly (ADP-ribose) from NAD+. In this study, we used RMSF, hydrogen bond, hydrophobic, and MMPBSA analyses to construct an interface-specific map of PARP1 activation, revealing how DNA, Zn ions, and NAD+ act at each domain interface to drive activation.

Pharmacological properties of Bergenia ciliata synthesized green zinc sulfide nanoparticles (ZnS-NPs) and zinc oxide nanoparticles (ZnO-NPs).

The conventional physical and chemical synthesis of nanomaterials is associated with multiple disadvantages, such as high energy consumption, high cost, time consumption, and the use of toxic chemicals that are not only hazardous in the manufacturing setup but are also harmful to the environment. To overcome such limitations, phytofabrication, i.e.

Functional Genomics and Probiotic Traits of Lactiplantibacillus plantarum MB685 from Fermented Broccoli: Gut Health and Metabolic Insights.

The current study aimed to isolate and characterize probiotic bacteria with potential health benefits from fermented broccoli. Sixteen bacterial strains were isolated, and two strains (MB685 and MB686) were selected based on their probiotic potential. The isolated strains showed tolerance to pH and temperature variations, and survived well in bile salt concentrations of 0.

Perylene-based Electron Transport Materials in Perovskite Solar Cells To Improve Power Conversion Efficiency.

Perovskite solar cells (PSCs) are highly efficient and flexible; thus, they have garnered a lot of focus. In the past, many fullerene compounds, such as PCBM, were employed as electron transport layers in PSCs. PCBM has several drawbacks, including surface trapping states, limited electron mobility, poor photochemical as well as thermal stability, a low open-circuit voltage, and significant recombination losses.

Chlorpyrifos and Bifenthrin Induced Histopathological and Biochemical Alterations in Different Organs of Hypophthalmichthys molitrix.

Chlorpyrifos (CPF) and bifenthrin (BF) are two of the most commonly used pesticides in the agriculture sector, which may accumulate in the environment and cause biotoxicity. The current study was conducted to check the potential toxicity of CPF and BF on Hypophthalmichthys molitrix. The 96 h-LC of CPF, BF, and their mixture were calculated as 11.