Comparative analysis of phytocompounds and repurposed drugs against dengue virus serotypes employing an in silico study.

Dengue virus (DENV) has emerged as a formidable global health challenge, with a surging incidence rate across the world. Despite numerous research initiatives aimed at developing effective antiviral therapy, no clinically proven drug or vaccine has been identified to combat all four genetically diverse serotypes of DENV. Therefore, comparative analysis of repurposed drugs and phytocompounds against all DENV serotypes is critical in the search for an effective long-term solution to this menacing disease.

Potential Role of N-NH Cardiac PET in Monitoring Treatment Response in Patients with Microvascular Angina.

Ischemia with nonobstructive coronary artery disease (INOCA) refers to patients who present with signs and symptoms of myocardial ischemia despite the absence of obstructive coronary artery disease. Coronary microvascular dysfunction (CMD) is one of the underlying causes of INOCA and is associated with an increased risk of major adverse cardiac events. CMD is often detected as impaired coronary flow reserve (CFR) during invasive coronary angiography.

Patient reported outcomes for symptom toxicity in breast cancer patients undergoing radiotherapy.

Background: Patient reported outcomes (PRO) usually report greater symptom toxicity compared to physician reported outcomes (PhyRO). In the present study, we measured PRO about symptom toxicity in breast cancer patients undergoing adjuvant radiotherapy and compared them with the PhyRO. We analysed the factors responsible for greater symptom severity on PRO.

Exploring Benign Vocal Cord Polyp Treatment: A Holistic Analysis of Plasma Ablation and Laser Excision Phonosurgery Practices Incorporating Subjective, Objective, and Videostroboscopic Assessments.

Unlabelled: Surgical techniques for benign vocal cord lesions, such as vocal cord polyps, have witnessed rapid technological advancements. It is imperative for developing nations like India to keep pace with this evolving technology. Our study compares two recently introduced modalities of vocal cord polyp treatment, assessing both subjective and objective outcomes.

Gallium-68-labeled radiopharmaceuticals: a review.

This review delves into the realm of gallium-68 (Ga)-labeled radiopharmaceuticals. Over the last decade, Ga-labeled radiopharmaceuticals have gained prominence and shown tremendous growth in both preclinical evaluation and clinical translation due to their accessibility, favourable physical properties, and simple chemistry. Despite the high positron emission energy of 836 keV, it has been extensively used in diagnostic imaging.

Unmet needs in hereditary angioedema: an international survey of physicians.

Background: Hereditary angioedema (HAE) is a rare and potentially life-threatening genetic disorder characterized by unpredictable attacks of angioedema. MENTALIST (UnMEt Needs in herediTAry angioedema-a gLobal physIcian perSpecTive) is the first international survey uncovering unmet needs and identifying barriers to optimal management in HAE following the latest update of the World Allergy Organization (WAO)/European Academy of Allergy and Clinical Immunology (EAACI) HAE guidelines.

Methods: This web-based survey comprised 24 questions on HAE management and unmet needs.

Clinicodemographic Features and Usage of Oral Immunosuppressive Agents in Childhood and Adolescent Vitiligo: Retrospective Chart Review From a Tertiary Care Centre in Northern India.

Background: Vitiligo is a common acquired depigmentation disorder with significant psychosocial implications, especially in pediatric populations. Despite the availability of topical treatments, systemic immunosuppressive agents are increasingly being explored for progressive disease. However, limited data exist regarding their efficacy and safety in pediatric vitiligo.

Diagnosing apparent mineralocorticoid excess in a child with hypertension and nephrocalcinosis: from symptoms to genetics.

Apparent mineralocorticoid excess (AME) is a rare genetic disorder caused by reduced activity of the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme. It is characterized by hypertension, hypokalemia, and low levels of renin and aldosterone. This study presents the case of a 2-year-old female patient who exhibited abdominal distension, hypertension, recurrent hypokalemia with metabolic alkalosis, failure to thrive, polyuria, and features of rickets.

From promise to practice: a scoping review of AI applications in abdominal radiology.

AI is rapidly transforming abdominal radiology. This scoping review mapped current applications across segmentation, detection, classification, prediction, and workflow optimization based on 432 studies published between 2019 and 2024. Most studies focused on CT imaging, with fewer involving MRI, ultrasound, or X-ray.

One-year outcomes of Bent ab-interno needle goniectomy with phacoemulsification in primary glaucoma.

Purpose: To study 1-year outcomes of bent ab-interno needle goniectomy (BANG) with phacoemulsification in patients across the glaucoma spectrum.

Methods: This Prospective, noncomparative interventional study enrolled primary glaucoma patients (open-angle and angle-closure) with medically controlled intraocular pressure (IOP) and visually significant cataracts who underwent clear corneal phacoemulsification with intraocular lens placement combined with BANG using a 25-gauge needle bent as a reverse cystitome. Patients completing a minimum 1-year post-surgical follow-up were analyzed.

Brittle Cornea Syndrome Type 1 in Siblings: Severe Presentation in One and Misdiagnosis as Primary Congenital Glaucoma in the Other.

Purpose: The purpose of this study was to present two cases of brittle cornea syndrome (BCS) in siblings, one with severe corneal perforation and the other misdiagnosed as primary congenital glaucoma, emphasizing clinical, histopathological, and genetic findings.

Methods: This was a case report involving a 4-year-old boy and his 8-year-old brother, both presenting with thin, steep corneas. Clinical examination, Pentacam imaging, genetic analysis, systemic evaluation, and corneal histopathology were performed.

Clinical and molecular epidemiology of chikungunya outbreaks during 2019-2022 in India.

Chikungunya fever (CHIKF) is endemic in India, with multiple outbreaks occurring across the country since its reemergence in 2005. Suspected CHIKF patients were recruited from four clinical sites during 2019-2022, with data collected on sociodemographic, clinical, and epidemiological aspects. Sera samples were screened for IgM, IgG antibodies and viral RNA along with their neutralizing capacity.

Diagnosis, evaluation and management of osteoporosis in chronic kidney disease: navigating treatment approaches - Indian consensus statement.

Background: Managing osteoporosis (OP) in chronic kidney disease (CKD) presents significant challenges due to altered bone metabolism. Given the lack of robust clinical trial data and a notable knowledge gap exists among nephrologists regarding an optimal management in this population, an expert consensus is crucial for developing tailored management strategies. This study aimed to gather an expert opinion to bridge this gap and establish consensus recommendations on the diagnosis and management of osteoporosis in CKD patients.

Building a Future without Blindness due to Retinopathy of Prematurity in India: Progress, Challenges, and the Way Forward.

Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness in India. We examined the progress, current status, and challenges related to ROP in India. Despite national guidelines and initiatives, the coverage of ROP screening remains highly variable across regions.

Machine learning in dentistry: a scoping review.

Artificial intelligence (AI), specifically machine learning (ML), is increasingly applied in decision-making for dental diagnosis, prognosis, and treatment. However, the methodological completeness of published models has not been rigorously assessed. We performed a scoping review of PubMed-indexed articles (English, 1 January 2018â€'31 December 2023) that used ML in any dental specialty.

Assessing the Role of Statins as an Adjunctive Anti-VEGF Therapy for Clinically Significant Macular Edema (CSME) in Type 2 Diabetes Mellitus.

Aim: This study aimed to evaluate the effectiveness of statin therapy as an adjunctive treatment to anti-VEGF therapy in type 2 diabetic patients with non-proliferative diabetic retinopathy (NPDR) and clinically significant macular edema (CSME).

Materials And Methods: In this prospective, randomized interventional study, patients were randomized into two groups: Group A received low-dose atorvastatin (10-20 mg), and Group B received high-dose atorvastatin (30-40 mg). All participants also received three loading doses of intravitreal ranibizumab (0.

Haemophagocytic lymphohistiocytosis triggered by Rickettsia conorii.

Haemophagocytic lymphohistiocytosis (HLH) is a rare complication of rickettsial infections. We report a 50-y-old man from northern India who presented with fever, respiratory distress, altered sensorium and an eschar. Despite treatment with doxycycline, his condition deteriorated with multi-organ dysfunction.

Pediatric David procedure for aneurysmally dilated ascending aorta in Loeys-Dietz syndrome.

Loeys-Dietz syndrome (LDS) is a rare congenital disorder that necessitates surgical intervention for a dilated ascending aorta. This case report details a case involving a 3-year-old patient diagnosed with Loeys-Dietz syndrome, presenting with a significantly dilated ascending aorta and severe aortic insufficiency, alongside various connective tissue anomalies associated with the syndrome. Intraoperative assessment revealed severe dilatation of the aortic root and ascending aorta.