Choroidal Vascularity Index as a marker of health and disease: Systematic review and meta-Analyses.

The Choroidal Vascularity Index (CVI), derived from optical coherence tomography (OCT), has emerged as a potential biomarker for detecting vascular changes. Understanding its variability across physiological states, ocular conditions, and systemic diseases is crucial for its integration into clinical practice. We evaluated variations in CVI across different physiological states (e.

Detection and quantification of fluorescein angiography leakage: From manual grading to advances in machine learning.

Fluorescein angiography (FA) has long been a cornerstone for evaluating retinal vascular leakage in diseases like uveitis, diabetic retinopathy, and macular degeneration, but its interpretation relies on subjective grading that can vary between clinicians. With the emergence of artificial intelligence (AI), there is a push to transform this qualitative assessment into objective, quantifiable metrics. We conducted a comprehensive literature search using PubMed, Embase, and Scopus, combining keywords and MeSH terms related to fluorescein angiography leakage, artificial intelligence, and retinal vascular diseases.

Machine Learning for Predicting Recurrent Course in Uveitis Using Baseline Clinical Characteristics.

Purpose: We developed and evaluated machine learning models for predicting the risk of recurrent uveitis using baseline clinical characteristics, to inform clinical decision-making and risk stratification.

Methods: A retrospective analysis was conducted using the Ocular Autoimmune Systemic Inflammatory Infectious Study registry, including 966 patients (1432 eyes) with uveitis. Three machine learning classifiers-random Forest, eXtreme Gradient Boosting, and radial basis function support vector classifier-were trained on preprocessed baseline demographic and clinical data.

Impact of Timing During Simulated Vitreoretinal Surgery by Trainees.

Purpose: This study aimed to examine the impact of surgical timing on the performance of vitreoretinal (VR) trainees in a simulated setting.

Methods: In a prospective cross-over observational study, VR trainees were asked to perform various surgical tasks on the Eyesi surgical simulator. These included navigation and anti-tremor, pars plana vitrectomy and posterior vitreous detachment, bimanual training, bimanual scissors use, and epiretinal membrane peeling.

The Association of Diabetes Mellitus with Uveitis: A Real-World Data Analysis.

Purpose: To evaluate the association between type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM) with the incidence of uveitis.

Methods: This was a retrospective cohort study utilizing the TriNetX Global Collaborative Network. Anonymized participants were patients diagnosed with T2DM or T1DM, including both insulin users and non-insulin users among those with T2DM, with and without diabetic retinopathy (DR).

Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry.

Objectives: To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU).

Methods: Predictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined.

Minimum Imaging Sets for Diagnosis, Activity Assessment, and Complications in Noninfectious Posterior Uveitis - Multimodal Imaging in Uveitis (MUV) Task Force Report 9.

Purpose: To evaluate a minimum imaging set (MIS) to support ophthalmologists in diagnosing, monitoring disease activity, and identifying disease-specific complications for six types of noninfectious posterior uveitides (NIPU).

Design: Visual questionnaire answered live by a group of ophthalmologists.

Participants: International group of ophthalmologists, including uveitis experts, medical retina experts, general ophthalmologists, and ophthalmologists-in-training.

Assessing the Role of Statins as an Adjunctive Anti-VEGF Therapy for Clinically Significant Macular Edema (CSME) in Type 2 Diabetes Mellitus.

Aim: This study aimed to evaluate the effectiveness of statin therapy as an adjunctive treatment to anti-VEGF therapy in type 2 diabetic patients with non-proliferative diabetic retinopathy (NPDR) and clinically significant macular edema (CSME).

Materials And Methods: In this prospective, randomized interventional study, patients were randomized into two groups: Group A received low-dose atorvastatin (10-20 mg), and Group B received high-dose atorvastatin (30-40 mg). All participants also received three loading doses of intravitreal ranibizumab (0.

Evaluation of Derived Cell-Free DNA-Based Multi-Targeted Real-Time PCR from Vitreous Fluid (VF) Samples to Diagnose Ocular Tuberculosis.

Background: Ocular tuberculosis (OTB) is an important cause of vision loss in India. Rapid and accurate diagnosis of OTB is paramount to decreasing morbidity and saving the eyes from blindness. DNA present in cell-free form is expected to give a higher detection yield.

Systematic Review of Clinical Utility of Multimodal Imaging in Noninfectious Posterior Uveitis: MUV Project Report 3.

Topic: The clinical utility of multimodal imaging for diagnosis and management of non-infectious posterior uveitis.

Relevance: Advances in multimodal imaging support amendment of the imaging strategies in the authoritative classification criteria published by the Standards of Uveitis Nomenclature II in 2021.

Methods: Peer-reviewed electronic search in OVID MEDLINE, Embase, Cochrane, Scopus, last accessed August 6, 2024.

Evidence and Consensus Based Imaging Guidelines in Multiple Evanescent White Dot Syndrome Multimodal imaging in Uveitis (MUV) Taskforce Report 6.

Purpose: To develop imaging and consensus-based guidelines on the application of multimodal imaging in multiple evanescent white dot syndrome (MEWDS).

Design: Consensus agreement guided by literature, and an expert committee using a nominal group technique (NGT).

Methods: The expert committee employed a structured NGT with multiple rounds of discussion, conflict resolution, and anonymous voting to: (1) establish imaging criteria for diagnosing and monitoring MEWDS using color fundus photography (CFP), optical coherence tomography (OCT), fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and OCT angiography (OCTA); and (2) develop consensus-based recommendations for assessing specific characteristics in patients with MEWDS.

Evidence and Consensus-Based Imaging Guidelines in Noninfectious Posterior Uveitis-Methodology of the Multimodal Imaging in Uveitis (MUV) Project Report 2.

Purpose: The Multimodal Imaging in Uveitis (MUV) project is a comprehensive initiative aimed at developing guidelines for the use of multimodal imaging (MMI) in diagnosing and managing noninfectious posterior uveitis (NIPU). This project seeks to develop standardized guidelines and a minimal imaging set leading to evidence and consensus-based imaging guidelines that are applicable across diverse clinical settings. This manuscript describes the overall goals and methodology of the project.

Evidence and Consensus-based Imaging Guidelines in Birdshot Chorioretinopathy: Multimodal Imaging in Uveitis (MUV) Taskforce Report 8.

Purpose: To develop consensus-based imaging guidelines for diagnosing and monitoring birdshot chorioretinopathy (BSCR).

Design: Consensus-based approach guided by literature and an expert committee using a nominal group technique (NGT).

Methods: An expert committee of 5 international uveitis specialists reviewed 15 well-documented representative BSCR cases with comprehensive imaging data.

Evidence and Consensus-Based Imaging Guidelines in Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) - Multimodal imaging in Uveitis (MUV) Taskforce Report 7.

Purpose: To develop consensus-based guidelines on use and interpretation of multimodal imaging in acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Design: Consensus agreement led by literature, and an expert committee using a nominal group technique (NGT).

Methods: The expert committee for APMPPE performed a thorough review of representative cases of APMPPE.

Evidence and Consensus-Based Imaging Guidelines in Serpiginous Choroiditis-Multimodal Imaging in Uveitis (MUV) Task Force Report 4.

Purpose: To develop imaging and consensus-based guidelines for the application of multimodal imaging in serpiginous choroiditis (SC).

Design: Consensus agreement guided by literature search, and an expert committee using a nominal group technique.

Methods: An expert committee gathered cases of noninfectious SC based on predefined informatics-driven inclusion criteria.

A Survey of Diagnostic and Management Practices in Retinal Vasculitis: International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe)-Report 5.

Purpose: Retinal vasculitis (RV) is a complex inflammatory disorder of retinal blood vessels with variability in diagnosis, classification, and management. Despite efforts to standardize definitions, discrepancies persist regarding clinical features, systemic associations, and treatment approaches. This study aimed to assess clinical practices among uveitis specialists to identify areas requiring consensus.

Clinical features of retinal vasculitis: A systematic review and meta-analysis from the International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 3.

We investigate the clinical characteristics and complications of retinal vasculitis (RV), categorizing cases into Secondary RV (associated with systemic disease), Syndromic RV (linked to ocular syndromes without systemic disease), Idiopathic RV (without systemic disease or ocular syndrome diagnoses), and Multiple Etiology RV (cohorts of retinal vasculitis with more than one subcategories of the above). A systematic search was conducted on June 14, 2023, across PubMed, Embase, Cochrane (Ovid), VHL, and ProQuest databases, following PRISMA guidelines (PROSPERO registration: CRD42023489232). Out of 5533 screened articles, 97 studies involving 7619 patients with RV met the eligibility criteria.

Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics.

Purpose: The Programme for Ocular Inflammation & Infection Translational Research (PROTON) registry collects real-world data on infectious and non-infectious ocular inflammatory diseases (OID) to enhance understanding of disease progression and treatment outcomes. This report presents the baseline characteristics of patients enrolled in two international multicentric studies, OASIS 1 and OASIS 2, over the first two years.

Design: A cross-sectional observational study.

Evidence and Consensus-Based Imaging Guidelines in Multifocal Choroiditis With Panuveitis and Punctate Inner Choroiditis-Multimodal Imaging in Uveitis (MUV) Taskforce Report 5.

Purpose: To develop imaging and consensus-based guidelines on the application of multimodal imaging in noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC).

Design: Consensus agreement guided by the review of literature and an expert committee using nominal group technique (NGT).

Methods: An expert committee applied a timed structured nominal group technique (NGT) to achieve consensus-based recommendations on specific disease characteristics, biomarkers of activity, and complications for MFCPU and PIC.

Retinal Vasculitis in Familial Blau Syndrome.

Introduction: Blau syndrome is a rare autosomal dominant condition resulting from mutations in the Nucleotide Oligomerization Domain of 2 ;(NOD2) gene. The disease typically presents in early childhood with a triad of arthritis, dermatitis, and uveitis. In this report, we describe retinal vasculitis as a rare phenotype in a family affected by Blau syndrome.