Snail shell on Moon appearance: Cataracta Nigra over Coloboma.

We report a rare case of posteriorly dislocated cataracta nigra associated with fundal coloboma with vitreous hemorrhage in a 50-year-old Asian female presenting with a history of blunt ocular trauma 5 years prior. The patient's visual acuity was limited to light perception, and anterior segment examination revealed a typical iris coloboma. Posterior segment visualization was obscured by dense vitreous hemorrhage.

Specific Combinations of Physiological Tau Phosphorylation Regulate Tau-Microtubule Interactions in Developing Neurons.

Tau phosphorylation is a defining feature of Alzheimer's disease, yet it also plays an essential physiological role in stabilizing microtubules (MTs) during normal neuronal development. While individual phosphorylation sites have been well-studied in pathology, it remains largely unknown how combinatorial phosphorylation is regulated under physiological conditions. Here, we uncover distinct, site-specific phosphorylation patterns on tau in developing human neurons.

Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation-Wide Multicenter Study.

Background: Parkinson's disease (PD) phenotype may vary with genetic, ethno-geographic, cultural, and environmental factors.

Objectives: The aim was to develop a clinical database of PD in India and assess the influence of age-at-onset (AAO), gender, and motor subtype on the clinical profile of PD.

Methods: A cross-sectional study of PD was conducted across 18 Indian hospitals.

Levothyroxine therapy and its impact on serum lipids: Addressing dyslipidemia in hypothyroidism.

Background And Objective: The major goal of this study was to analyse the influence of levothyroxine medication on serum lipid levels in individuals with hypothyroidism, as well as its efficacy in controlling dyslipidemia caused by thyroid hormone deficiencies. This method provides a complete assessment of therapy efficacy and aids in identifying factors that may influence treatment results.

Methodology: This prospective observational study, conducted from September 2019 to October 2020 at Shri Shiv Prasad Gupt Divisional District Hospital in Varanasi, India, included 150 patients with newly diagnosed hypothyroidism.

Profiling HIV1-host protein-protein interaction networks in patient-derived exosome proteins: impact on pathophysiology and innate immune pathways.

Objectives: The objective of this research is to investigate the pathophysiological progression of HIV from acute infection to chronic immunodeficiency (AIDS) and to understand the host's immunological responses, which are pivotal for elucidating disease aetiology and optimizing antiretroviral therapy (ART). Additionally, the study aims to explore the role of exosomes (40-130 nm bilipid-layered vesicles released by nearly all cell types) as key mediators of intercellular communication in the context of HIV infection.

Materials And Methods: Recent research has uncovered that cells infected with HIV-1 release exosomes carrying a mix of viral and host components such as proteins, nucleic acids, lipids, and other metabolites.

Bacterial endotoxin-lipopolysaccharide role in inflammatory diseases: An overview.

Despite advancements in antimicrobial and anti-inflammatory treatments, inflammation and its repercussions continue to pose a considerable challenge in medicine. Acute inflammation may cause life-threatening conditions like septic shock, while chronic inflammation leads to tissue degeneration and impaired function. Lipopolysaccharides (LPS), a well-known pathogenic trigger contributing to several dysfunctions, is a crucial part of the outer membrane of gr-negative bacteria.

Linking prosthodontics and periodontics: An implant success rate.

Implant success is significantly influenced by the interplay of prosthodontic and periodontal factors, as demonstrated in this study of 20 subjects undergoing dental implant placement. Key findings highlight a strong correlation between implant stability and periodontal health, particularly gingival health and bone density, while prosthodontic elements such as occlusal load and abutment stability also played pivotal roles. Patients with balanced occlusal forces, stable abutments and healthy periodontal profiles achieved over 90% success in stability and functionality.

Accelerated neurostimulation protocols for auditory hallucinations: a systematic review and meta-analysis.

Objective: To explore the efficacy and characteristics of accelerated (more than once daily) protocols of repetitive transcranial magnetic stimulation (rTMS) and transcranial Electrical Stimulation (tES) in treating auditory hallucinations (AH) and other psychotic symptoms.

Methods: "We searched Pubmed" using relevant MeSH terms and keywords to identify relevant literature. Standard mean difference (SMD) and 95% confidence interval (CI) values were used to evaluate the effects of rTMS and tES.

Crumpled posterior subcapsular cataract.

Posterior subcapsular cataract(PSC) is a type of cataract that forms at the back of lens, just in front of the posterior capsule. It is commonly tends to affect younger patients. PSC with crumpled posterior capsule is an unusual finding that can result from trauma, surgery or developmental issues.

Exploring virulence and stress response in : insights from clinical strains.

Amebiasis, caused by the protozoan , is a significant parasitic infection affecting millions of people worldwide, particularly in developing regions. Elucidating the mechanisms by which this parasite invades host tissues and circumvents immune defenses is essential for advancing therapeutic strategies. Key virulence factors such as Gal/GalNAc lectin, amebapore, and proteases enable the parasite to adhere to, invade, and destroy host tissues.

Investigating postbiotics as innovative adjuvants: deciphering the gut-breast connection in breast Cancer therapy, from gut microbiome to personalized medicine.

Breast cancer is the most common and deadly cancer affecting women globally. While traditional treatments - surgery, chemotherapeutic agents, radiotherapy - are used, factors damage their effectiveness: tumor heterogeneity, drug resistance, and non-targeted actions on cancer cells. Postbiotics, a newer category of biotics, confer benefits without living microorganisms and show promise against cancer.

Membrane transporters in Plants: Key players in abiotic and biotic stress tolerance and nutritional transport.

Various abiotic and biotic stressors, including water extremes, temperature fluctuations, salinity, and heavy metals, pathogens and diseases significantly reduce global crop yields. Rapid plant responses are essential for adapting and minimizing metabolic losses. In this context, plant transporters (PTs) are essential for modulating stress responses by enabling the passage of diverse molecules and ions through the plasma membrane.

Laminar fluid ejection device enables high yield and preservation of mRNA and SaRNA LNP formulations.

The development of messenger RNA (mRNA) and self-amplifying RNA (saRNA) vaccines has revolutionized modern vaccinology, particularly with the success of lipid nanoparticle (LNP)-based SARS-CoV-2 vaccines. Intranasal administration offers a promising approach for respiratory vaccines, providing mucosal immunity at the primary entry site of pathogens. However, the impact of different aerosolization delivery systems on RNA-LNP stability, recovery volume and functionality is not well understood.

Imidazopyridine Based Fluorescent Turn-Off Sensor for Selective Recognition of Fe Ions and its Application in Test Strips.

A series of 2-ethoxycarbonyl imidazopyridines have been synthesised and characterised by various spectroscopic techniques (H NMR, C NMR, FTIR and HRMS). Among these compounds, 3e was selected for metal sensing applications due to its favourable photophysical properties. 3e demonstrated high selectivity and sensitivity for detecting Fe ions, even in the presence of other competing ions in a mixture of acetonitrile/water (1:9, v/v).

Impact of an artificial intelligence-driven operational management system on operational efficiency in health care organization in Saudi Arabia: a mediating role of staff attitude.

Introduction: In recent years, Artificial Intelligence (AI) is transforming healthcare systems globally and improved the operational efficiency in healthcare organizations. The authors examined how an artificial intelligence (AI)-driven operational management system (OMS) affected operational efficiency in health care units in the Kingdom of Saudi Arabia (KSA). They also investigated the mediating role of staff attitudes in the relationship between OMSs and operational efficiency.

Adoption challenges to artificial intelligence literacy in public healthcare: an evidence based study in Saudi Arabia.

In recent years, Artificial Intelligence (AI) is transforming healthcare systems globally and improved the efficiency of its delivery. Countries like Saudi Arabia are facing unique adoption challenges in their public healthcare, these challenges are specific to AI literacy, understanding and effective usage of AI technologies. In addition, cultural, regulatory and operational barriers increase the complication of integrating AI literacy into public healthcare operations.

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins have been linked to central nervous system diseases.

Layered double hydroxide based composite core-shell electrospun nanofibers for lead and fluoride filtration from contaminated streams.

Coaxial electrospinning was used to synthesize polyacrylonitrile-polyethersulfone (PAN-PES) core-shell nanofibers with magnesium-aluminum layered double hydroxide (Mg-Al LDH) for filtration of lead and fluoride from contaminated streams. Fiber geometry was characterized at a 0.5 mL h flow rate for the core polymer (PES/LDH) and 0.

Retinal Vasculitis in Familial Blau Syndrome.

Introduction: Blau syndrome is a rare autosomal dominant condition resulting from mutations in the Nucleotide Oligomerization Domain of 2 ;(NOD2) gene. The disease typically presents in early childhood with a triad of arthritis, dermatitis, and uveitis. In this report, we describe retinal vasculitis as a rare phenotype in a family affected by Blau syndrome.

Unlocking the Power of AI: Healthcare Workforce Perception and Its Impact on their Work Performance in Saudi Arabia.

Objective: To investigate the perception of AI among the healthcare workforce and its impact on their performance, with technology readiness acting as a moderating factor.

Methods: In this cross-sectional study, a close-ended, self-administered survey questionnaire was used between 02 June to 04 August, 2024 to collect responses from 434 participants working in the public hospitals in Hail health cluster in Saudi Arabia. The study employed demographic summaries, descriptive statistics, regression analysis using Hayes' Process, and regression diagnostics for data analysis.