Can Glycerol Be Used as an Effective Alternative Storage Medium for Avulsed Teeth Before Replantation?

Introduction For successful replantation of avulsed teeth, preserving the vitality of periodontal ligament (PDL) cells of the avulsed tooth is important. The aim of the present study was to evaluate the usage of glycerol by comparing its different concentrations with the gold standard medium, i.e.

Repurposing Diabetes Therapies in CKD: Mechanistic Insights, Clinical Outcomes and Safety of SGLT2i and GLP-1 RAs.

Chronic Kidney Disease (CKD) is a major global health issue, with diabetes being its primary cause and cardiovascular disease contributing significantly to patient mortality. Recently, two classes of medications-sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs)-have shown promise in protecting both kidney and heart health beyond their effects on blood sugar control. We conducted a narrative review summarizing the findings of different clinical trials and mechanistic studies evaluating the effect of SGLT2i and GLP-1 RAs on kidney function, cardiovascular outcomes, and overall disease progression in patients with CKD and DKD.

Genetic and bioinformatic analysis of RHO and PRPH2 variants in north Indian retinitis pigmentosa patients.

Purpose: Retinitis Pigmentosa (RP) represents the most common form of inherited retinal dystrophy (IRD), identified by a gradual degeneration of photoreceptors, ultimately resulting in nyctalopia and impaired vision. This study was conducted to screen the rhodopsin and peripherin2 genes for possible pathogenic mutations in north Indian RP patients.

Study Design: We focused on assessing the whole coding region and the intron-exon boundaries of RHO and PRPH2 genes in RP patients and control subjects.

A Chemically Robust Zn-MOF with a Dual Role as a Symmetric Supercapacitor and Sustainable Hydrogen Storage Material.

To achieve single-component multienergy storage materials with a chemically robust MOF, we introduce a 3D paddlewheel MOF, {[Zn(4-pmi)(hfipbb)].(HO)}, synthesized and characterized through elemental analysis, SEM, XPS, IR spectroscopy, PXRD, TGA, and SCXRD. This MOF is conspicuous with thermal stability up to 350 °C and structural integrity across harsh conditions including acidic, alkaline, open-air, high pressure, and organic solvent environments, ensuring unmatched durability.

Elicitation with CaCl and SNP enhance antioxidant defense and regulate transcriptional changes in drought-stressed saffron.

Calcium chloride and sodium nitroprusside mitigate PEG-induced drought in saffron by enhancing antioxidant defense, osmolyte levels, and stress-responsive genes expression, promoting resilience and adaptive growth. While calcium ions (Ca) and nitric oxide (NO), are key signalling mediators, which enhance plant's ability to survive abiotic stress, their definitive role in enhancement of drought tolerance in saffron is not fully studied yet. We aim to examine the effect of different concentration of calcium chloride (CaCl) (25, 50, 75 mM) and sodium nitroprusside (SNP) (25, 50, 100 µM) on saffron cultured on MS media containing 10% polyethylene glycol (PEG) for 30 days.

Development of novel 1,4-Dihydropyridine-tethered Isatin scaffolds as potential candidates for the treatment of Cancer and fungal infections.

The pursuit of novel therapeutic agents with potent anticancer activity remains a key priority in medicinal chemistry, particularly for addressing liver and stomach malignancies, which continue to present substantial clinical challenges. In this study, we have reported the synthesis and biological assessment of a new series of novel 1,4-Dihydropyridine (DHP) tethered Isatin scaffolds, aimed at identifying promising candidates with significant anticancer potential. A combined approach of in-silico ADMET analysis, molecular docking and in-vitro cytotoxic screening was employed.

Subsidence Following Anterior-Only Anterior Cervical Corpectomy Fusion For Cervical Spondylotic Myelopathy: Systematic Review and Meta-Analysis.

Study Design: Systematic review and meta-analysis.

Objective: To examine the occurrence and potential contributing factors of interbody subsidence following anterior-only ACCF performed for CSM.

Summary Of Background Data: Surgical interventions for cervical spondylotic myelopathy (CSM) frequently involve anterior approaches, such as anterior cervical discectomy/fusion (ACDF) or anterior cervical corpectomy/fusion (ACCF).

Abscisic acid-mediated modulation of morpho-physiological traits and transcript accumulation improves drought resilience in Crocus sativus L.

Drought is a major abiotic factor leading to decreased productivity. The current study investigates the effects of prolonged drought stress and subsequent recovery in Crocus sativus L. through the exogenous application of abscisic acid (ABA) under field conditions in the Dhauladhar range of the Himalayan region.

Iron-Based Heterogenous Nanocatalyst from for Hantzsch, Knoevenagel, and Biginelli Reactions.

leaves (TOL) extract has been used for the synthesis of biogenic iron oxide nanoparticles (TOL-FeO NPs) using a green coprecipitation method, and its catalytic potential has been explored for multicomponent reactions (MCRs). Phytoconstituents such as phenolic compounds help in nanocatalyst formation and its stabilization. Comprehensive characterization using EDX, FE-SEM, XPS, FTIR, TGA, -XRD, and TEM, confirmed the successful synthesis of TOL-FeO NPs.

Blood Utilization Review Using Transfusion Indices in a Tertiary Care Center: A Retrospective Observational Study.

Background Excessive preoperative blood requisition often results in non-utilization, aging, and wastage of blood units and resources. Transfusion indices help assess the efficiency of the blood requisition process. Hence, this study aimed to analyze blood utilization patterns using transfusion indices across various departments in a tertiary care center.

FDG PET/CT Imaging in Mucormycosis: A Novel Approach for Early Detection and Disease Monitoring.

Background: To evaluate the role of FDG PET/CT in diagnosing and monitoring rhinocerebral mucormycosis (RCM) and its added value over conventional imaging.

Patients And Methods: We conducted a prospective observational study of 47 adults with biopsy-confirmed rhinocerebral mucormycosis between July 2022 and September 2024. All patients underwent FDG PET/CT, and findings were compared with MRI/CT and correlated with microbiological or histopathologic results.

Genetic insight into idiopathic male infertility in North India: Role of telomere maintenance genes.

Background: Despite having a sizeable population and an increasing incidence of infertility, South Asia is still underrepresented in genetic studies of male reproductive health. In this area, little is known about idiopathic male infertility, which is frequently associated with subtle genetic variations. Both TERT (chromosome 5 [5p15.

Exploring potential barriers and facilitators to integrate tuberculosis, diabetes mellitus, and tobacco control programmes in India.

Background: Co-integrating tuberculosis (TB), diabetes mellitus (DM), and tobacco control (TC) programmes in India could help address the triple burden of these diseases. However, limited information exists regarding the feasibility and determining factors of such integration. We explored potential barriers and facilitators to integrating TB, DM, and TC programmes in Ambegaon Block of Pune District, Maharashtra, and Ballabgarh Block of Faridabad District, Haryana, in India.

Ultra-narrow linewidth laser across the C-band using polarization-controlled dual-cavity feedback.

A standard method to reduce the linewidth of semiconductor lasers involves the use of external optical feedback (EOF). However, feedback powers less than 1 % usually trigger coherence collapse (CC), leading to chaotic laser dynamics and linewidth broadening. This paper explores a method to mitigate CC through precise tuning of the feedback polarization depending on the feedback power.

Modeling and enhancing the sensing performance of silicon nitride slotted-ring-resonator-based refractive index sensors.

In this work, a silicon nitride-based slotted ring resonator refractive index (RI) sensor is modeled using a coupled-mode theory approach. An analytical model for the bent slot waveguide is derived by solving fields with Hankel and Bessel functions. The continuity of across interfaces yields a system of eight equations forming an 8×8 matrix ().

Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: an open-label randomized controlled trial in Faridabad, India.

This open-label randomized controlled trial in India assessed the impact of a peanut-based energy-dense nutritional supplement (EDNS) on weight gain among undernourished adults with drug-susceptible pulmonary tuberculosis in India. EDNS significantly improved weight gain compared to standard care, offering a scalable solution for targeted nutritional support.

Covalent organic frameworks as emerging photocatalysts and electrocatalysts for renewable energy conversion.

Covalent organic frameworks (COFs) have emerged as efficient photo- and electrocatalysts owing to their ordered structures, high porosity, tunable electronic structures, and modular functionality. Recent developments have revealed the immense potential of COF-based catalysts in renewable energy generation processes, particularly in the oxygen evolution reaction (OER), oxygen reduction reaction (ORR), hydrogen evolution reaction (HER), and carbon dioxide reduction reaction (CORR). Several strategies, including heteroatom doping, metalation, engineering of donor-acceptor units, and hybridization with conductive materials, have demonstrated substantial enhancement in the catalytic efficiency of COFs.

Synthesis, Antifungal Activity, Molecular Docking, Aquatic Toxicity Prediction and 2D-QSAR of Pyrazole Derivatives as Potential Fungicides for Basmati Rice.

The major problems in basmati rice are sheath blight and bakanae diseases caused by Rhizoctonia solani and Fusarium fujikuroi, which significantly lower the productivity of basmati rice. However, the excessive use of fungicides can result in pathogen resistance, environmental overload and mammalian toxicity. Therefore, there is a need for new fungicides with novel modes of action, low toxicity and minimal residue.

Chitosan-derived materials as heterogeneous catalysts in A-coupling and click reaction: A comprehensive review.

Chitosan, a natural biopolymer, has garnered huge attention as a support for the immobilization of different catalysts due to its ability to coordinate with various metals. Furthermore, the possibility of functionalization of OH and NH functional groups in chitosan makes it an attractive material for fine-tuning its properties for desired organic transformation. In this review article, we have covered the potential of chitosan/functionalized chitosan-based materials, including magnetic chitosan nanocomposites as recyclable heterogeneous catalysts in A-coupling, and Huisgen 1,3-dipolar cycloaddition (click reaction).

Predictors of Type 3 Diabetes Mellitus among Elderly Living with and without Type 2 Diabetes Mellitus: A Cross-sectional Study in the Urban Area of West Bengal.

Introduction: In view of the latest evidence, dementia is also regarded as type 3 diabetes mellitus (T3DM) due to the important role of brain insulin resistance in its pathogenesis. Our study objectives were to find out the proportion and predictors of mild cognitive impairment (MCI) and T3DM (dementia) among the elderly people living with and without type 2 diabetes mellitus (T2DM) attending a medical college outpatient department (OPD).

Materials And Methods: A cross-sectional study was conducted comparing elderly patients from diabetes clinic OPD and general medicine OPD of a medical college in West Bengal.

Staphylococcal nuclease and tudor domain-containing protein 1: An emerging therapeutic target in cancer (Review).

Staphylococcal nuclease and tudor domain-containing protein 1 (SND1) is an oncoprotein that is overexpressed in various types of cancer, including breast, prostate, lung, colorectal and hepatocellular carcinomas, as well as malignant gliomas, especially in cases of advanced and metastatic cancer. SND1 has a significant role in tumour development via its interactions with RNA and partner proteins. SND1 functions as a nuclease within the RNA-induced silencing complex, where small RNAs (such as siRNAs or miRNAs) bind to ribonucleoproteins to mediate RNA interference and silencing of tumour suppressor genes.

Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer's Disease: A Therapeutic Review.

Alzheimer's disease (AD) is a multifactorial neuron-degenerative old age illness, which deteriorates the neuronal cells of the brain ultimately leading to dementia, decreased thinking ability and intricacy in performing daily routine activities. In most of the cases, AD is suspected to be caused by a combination of numerous factors, like environmental, genetic and lifestyle affecting the brain functioning. The present permitted treatments include N-methyl-Daspartate (NMDA) receptor antagonists, cholinesterase inhibitors, and their combinations, which provide only momentary and symptomatic relief.

Molecular imaging findings with F-FDG and Ga-FAPI PET/CT in a case of chronic polyarthralgia.

Positron emission tomography (PET) with F-fluorodeoxyglucose for detection of active inflammation is well documented; however, the visualization of immune-mediated tissue remodeling has not been possible till date. With the recent development of Ga-fibroblast activation protein inhibitors (FAPI), which specifically binds to the activated fibroblasts located around the synovium allowing for the visualization of mesenchymal and stromal activation process , it is possible to use this modality to use as an objective indicator of disease activity. We observed increased FAPI uptake around all the large joints of the bilateral upper and lower limbs of a chronic polyarthralgia patient.