Iron-Based Heterogenous Nanocatalyst from for Hantzsch, Knoevenagel, and Biginelli Reactions.

leaves (TOL) extract has been used for the synthesis of biogenic iron oxide nanoparticles (TOL-FeO NPs) using a green coprecipitation method, and its catalytic potential has been explored for multicomponent reactions (MCRs). Phytoconstituents such as phenolic compounds help in nanocatalyst formation and its stabilization. Comprehensive characterization using EDX, FE-SEM, XPS, FTIR, TGA, -XRD, and TEM, confirmed the successful synthesis of TOL-FeO NPs.

Assessing surgical outcomes in pituitary adenoma: A comparison of microscopic and endoscopic techniques.

Background: The advantages of endoscopic resection of pituitary adenomas over microscopic have been exhaustively documented in the literature, though controversy persists regarding the superiority of either technique. The microscopic technique being more common at our center, we compared the outcome of patients operated by microscopic transsphenoidal surgery (MTS) and endoscopic transsphenoidal surgery (ETS) approach.

Methods: Retrospective data on transsphenoidal surgery for nonfunctional adenomas between 2019 and 2023 were analyzed.

Navigating women with congenital heart disease during pregnancy: Management strategies and future directions.

Women with adult congenital heart disease (CHD) face unique challenges during pregnancy, as gestational cardiovascular (CV) and hemodynamic changes can exacerbate underlying cardiac conditions. While these adaptations are well tolerated in women with structurally and functionally normal hearts, they pose significant risks for those with adult CHD (ACHD), whether repaired, palliated, or with residual defects. Maternal CHD is associated with an increased risk of adverse CV events, including stroke, heart failure, arrhythmias, and thromboembolic complications during pregnancy and the peripartum period.

Recent Advances in Biogenic Nanoparticles for Water Remediation via Drug/Dye Degradation and Heavy Metals Detection.

Water pollution has become a major threat globally and is challenging due to widespread industrial and human activities. Various strategies have been considered for the safe use of water or its decontamination. Nanoparticles (NPs)-based methods for water purification have been widely explored, however, have major drawbacks associated with them, like use of harmful chemicals, high energy costs for their synthesis.

Effect of prone position on cerebral hemodynamics and noninvasive intracranial pressure assessed using transcranial Doppler in patients undergoing spine surgeries: a prospective observational study.

Background: The prone position, frequently used in spine surgeries for optimal surgical access, induces physiological changes in cardiovascular and respiratory parameters. Increased intraabdominal and intrathoracic pressures lead to elevated central venous pressure (CVP). Along with raised intrathoracic pressure, positive end-expiratory pressure (PEEP) results in elevated CVP, impeding venous blood flow from the brain and potentially affecting intracranial pressure (ICP).

Carbon dots: An emerging food analysis nanoprobes for detection of contaminants.

Carbon dots are the new class of nanomaterials with a size range of 10 nm or less. These are associate with the important material properties such as good biocompatibility, fluorescent nature, small size and easy to synthesize with low toxicity which make them the first choice over the fluorescent inorganic materials and dyes, to be used as biocompatible nanoprobes for the detection of food adulterations. Herein, we have focused on the methods of synthesis of these tiny zero dimensions, fluorescent nanomaterials (CDs), their properties, mechanism of fluorescence, and lastly their wide applications in food analysis which include the detection of additives, heavy metal ions, organic pollutants, foodborne microbes, antibiotic and pesticides.

Invasive haemodynamics predict outcomes in paediatric pulmonary artery hypertension.

Background: Invasive haemodynamics are often performed for initiating and guiding pulmonary artery hypertension therapy. Little is known about the predictive value of invasive haemodynamic indices for long-term outcomes in children with pulmonary artery hypertension. We aimed to evaluate invasive haemodynamic data to help predict outcomes in paediatric pulmonary artery hypertension.

Partial anomalous venous connection with intrapulmonary dual drainage: Transcatheter treatment of a rare entity.

Partial anomalous pulmonary venous return (PAPVR) is a rare congenital condition, and dual-drainage connection PAPVR to the left atrium has been reported in a few cases in the literature; in which cases, percutaneous catheterization was successfully used in lieu of surgery. We, hereby, describe a 7-month-old boy with a functional single-ventricle physiology with dual drainage of the left upper pulmonary vein to the left atrium and the innominate vein. Appropriate recognition of this entity allowed safe occlusion of the anomalous draining vein.

Catheter ablation of atrioventricular nodal reentrant tachycardia, when AVNRT presented as a fetus or infant.

Background: Atrioventricular nodal reentrant tachycardia (AVNRT) does not commonly present during infancy. Although relative safety of catheter ablation of AVNRT has been demonstrated in pediatrics, this procedure is rarely indicated in children <15 kg.

Methods: Retrospective review of seven cases of AVNRT that presented in children younger than 1 year of age and required catheter ablation for definitive management.

Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes.

New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary efficacy endpoint for kidney transplant clinical trials through European Medicines Agency's qualification of novel methodologies for drug development. This is the first qualified endpoint for any transplant indication and is now available for use in kidney transplant clinical trials.

Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials.

Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for Duchenne muscular dystrophy (DMD), industry receives minimal guidance on how to use these biomarkers most beneficially in trials. This study aims to identify the optimal use of muscle fat fraction biomarkers in DMD clinical trials through a quantitative disease-drug-trial modeling and simulation approach. We simultaneously developed two multivariate models quantifying the longitudinal associations between 6-minute walk distance (6MWD) and fat fraction measures from vastus lateralis and soleus muscles.