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http://dx.doi.org/10.1017/S0022215125102909 | DOI Listing |
Curr Atheroscler Rep
September 2025
Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Purpose Of Review: Despite major advances in the treatment and prevention of atherosclerotic cardiovascular disease (ASCVD), a substantial burden of residual risk remains Obesity has been redefined as a primary and independent drivers of cardiovascular morbidity and mortality warranting focused attention.
Recent Findings: Obesity is now recognized as a chronic disease and a central contributor to residual cardiovascular risk through mechanisms including systemic inflammation, insulin resistance, dyslipidemia, and endothelial dysfunction. This review addresses the limitations of conventional obesity management and highlights emerging pharmacological therapies targeting the underlying adiposopathy.
Blood Cell Ther
August 2025
Department of Clinical Hematology and Medical Oncology, Postgraduate Institute Of Medical Education And Research (PGIMER), Chandigarh, India.
Background: Bone marrow (BM) Measurable Residual Disease (MRD) assessments underestimate disease burden in multiple myeloma, as focal lesions can exist outside the marrow. Functional imaging, like positron emission tomography-computed tomography (PET-CT), offers valuable insights into residual disease beyond the marrow. Combining marrow flow cytometry (FCM) with PET-CT for a composite MRD (cMRD) assessment before and after autologous stem cell transplant (ASCT) is expected to provide prognostic information, particularly in settings where patients receive extended duration of anti-myeloma therapy prior to ASCT.
View Article and Find Full Text PDFEnviron Epidemiol
October 2025
School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Background: Seasonal variation in mortality results from a combination of environmental, biological, and social factors, with ambient temperature recognized as a key contributor. However, comprehensive assessments disentangling temperature effects from other seasonal influences across a broad range of mortality causes remain limited. This study aimed to quantify and compare the mortality burden attributable to ambient temperature and broader seasonal variation across major causes of death in Spain.
View Article and Find Full Text PDFBiotechnol Bioeng
September 2025
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.
In this work, confocal microscopy is employed to study the loading and fouling behavior in AAV affinity resins as well as the implications of resin reuse with several commercial chromatographic materials and feed mixtures. Resin samples are obtained from both batch and column experiments, and confocal microscopy is carried out to examine the adsorption profiles in the beads after loading, wash, elution, and CIP steps. A comparison of PSDVB-based POROS CaptureSelect (PCS) AAV resins with agarose-based AVIPure AAV9 resins revealed distinct differences in both AAV transport and resin fouling.
View Article and Find Full Text PDFBr J Haematol
September 2025
Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
In allogeneic haematopoietic stem cell transplantation (HSCT), important clinical decisions depend upon assessment of chimerism, including immunosuppressant dosing and donor lymphocyte infusions (DLI), which in turn can have major impacts on disease control, graft-versus-host disease (GVHD), immunity and ultimately patient survival. There is a complex range of clinical and laboratory procedural considerations including methodology of testing, types of cell subset selection, frequency of testing, urgency of turnaround times (TATs), interplay with measurable residual disease (MRD) monitoring and duration of testing post-transplant. These aspects are routinely adapted according to disease indication, patient characteristics, donor source and intensity of transplant technique.
View Article and Find Full Text PDF