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Background Excessive preoperative blood requisition often results in non-utilization, aging, and wastage of blood units and resources. Transfusion indices help assess the efficiency of the blood requisition process. Hence, this study aimed to analyze blood utilization patterns using transfusion indices across various departments in a tertiary care center. Methodology This study employed a retrospective, observational design, utilizing blood bank records collected over a one-year period from April 1, 2023, to March 31, 2024. A total of 5,881 patients were analyzed. The primary aim was to evaluate blood utilization efficiency by calculating key transfusion indices based on the crossmatching and transfusion of packed red blood cells (PRBCs). These indices included the crossmatch-to-transfusion (C/T) ratio, transfusion probability (TP), and transfusion index (TI). Results Out of 6,694 blood requisitions received during the study period, 5,881 patients underwent PRBC transfusions. A total of 11,894 PRBC units were crossmatched, of which 7,759 (65.23%) units were ultimately transfused. Transfusion indices demonstrated notable variations across different departments. The General Surgery Department recorded the highest C/T ratio at 2.05, while Hemato-oncology and Radiotherapy achieved the highest TP of 96%. In contrast, Dermatology reported the lowest TP at 74%. Gastro-surgery stood out with the highest TI of 2.47. Despite these differences, all departments operated within the established acceptable transfusion thresholds, maintaining C/T ratios below 2.5, TP values above 30%, and TI levels exceeding 0.5. Conclusions Departments with outlier indices should adopt restrictive transfusion practices. Educational programs and department-specific guidelines can optimize blood utilization, reducing unnecessary transfusions, costs, and resource consumption.
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http://dx.doi.org/10.7759/cureus.88344 | DOI Listing |
Kaposi sarcoma (KS) is an angioproliferative malignancy associated with human herpesvirus 8 (HHV-8) infection, predominantly affecting immunocompromised patients such as those with HIV/AIDS. Despite advances in antiretroviral therapy, KS remains a significant cause of morbidity and mortality in this population, especially when diagnosis or treatment is delayed. Ocular involvement, although rare, can lead to significant functional impairment.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Nutrition Department, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.
Rationale: Extracorporeal membrane oxygenation (ECMO) is a life-support technology for refractory cardiac arrest, but the massive blood transfusions required during treatment significantly increase the risk of transfusion-related infections. Hepatitis E virus (HEV) - traditionally linked to fecal-oral transmission - is increasingly recognized as a transfusion-transmitted pathogen, especially in emergency settings where urgent blood product infusion is common and routine HEV screening in blood banks is often lacking. However, nursing strategies for managing acute HEV infection after ECMO remain poorly defined, highlighting the need to address this clinical gap.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Chulalongkorn University, Bangkok, Thailand.
Background: The interprofessional educational curriculum for patient and personnel safety is of critical importance, especially in the context of the COVID-19 pandemic, to prepare junior multiprofessional teams for emergency settings.
Objective: This study aimed to evaluate the effectiveness of an innovative interprofessional educational curriculum that integrated medical movies, massive open online courses (MOOCs), and 3D computer-based or virtual reality (VR) simulation-based interprofessional education (SimBIE) with team co-debriefing to enhance interprofessional collaboration and team performance using Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS). This study addressed 3 key questions.
PLoS One
September 2025
Department of Internal Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
In resource-limited settings in Africa, which harbour the greatest burden of Sickle Cell Disease (SCD) globally, poor care outcomes are driven in part, by a lack of trained healthcare providers (HCP) and an absence of context-specific treatment guidelines appropriate to the level of healthcare facility. The study aimed to evaluate the impact of a structured training program on HCP's knowledge of SCD in Ghana. This was prospective cross-sectional study involving HCPs from 46 health facilities from 4 out of 16 regions in Ghana.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai, China.
Background: Aging is accompanied by profound changes in immune regulation and epigenetic landscapes, yet the molecular drivers underlying these alterations are not fully understood.
Methods: Transcriptional profiles of peripheral blood samples from young and elderly individuals, together with aging-associated methylation probe data, were used to identify aging biomarkers. Transcriptomics and chromatin immunoprecipitation sequencing (ChIP-Seq) were conducted to explore potential regulatory mechanisms.