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http://dx.doi.org/10.1007/s10620-025-09270-x | DOI Listing |
Cureus
August 2025
Department of Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
Brucellosis is a neglected zoonotic infection in Nepal that is often underdiagnosed, particularly in regions considered to have low prevalence. Its presentation can mimic autoimmune or hepatic disorders, complicating timely diagnosis and management. Coexistence with hereditary conditions such as Gilbert syndrome can further obscure the clinical picture.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Rationale: Weaver syndrome is a rare congenital overgrowth disorder characterized by a wide spectrum of clinical manifestations that often overlap with other overgrowth syndromes. It is primarily caused by pathogenic variants in the Enhancer of Zeste Homolog 2 (EZH2) gene on chromosome 7q36.1.
View Article and Find Full Text PDFClin Epidemiol
August 2025
Research Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Background: Gilbert's syndrome (GS) is a common genetic disorder marked by elevated bilirubin levels due to UGT1A1 enzyme deficiency. While jaundice and some adverse drug reactions are the primary recognised clinical features, individuals with GS frequently report non-specific symptoms like fatigue, brain fog, and abdominal pain. This study investigates the symptoms and diagnostic triggers of GS using UK primary care electronic health records.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Background: Hepatoid adenocarcinoma (HAC) of the pancreas is a rare malignant tumor characterized by morphologic and immunophenotypic features resembling hepatocellular carcinoma. The tumor cells exhibit polygonal morphology with eosinophilic or clear cytoplasm and large, irregular nuclei. Immunophenotypically, the tumor cells are positive for alpha-fetoprotein (AFP) and glypican-3.
View Article and Find Full Text PDFIndian J Nephrol
July 2024
Department of Pediatrics, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
The pathological jaundice in neonates develops due to hematological, infectious, surgical causes. We present an interesting case of persistent neonatal hyperbilirubinemia, who was diagnosed to have urinary tract infection (UTI) and effectively managed. Unexplained persistent neonatal jaundice, poor response to phototherapy, and higher rebound total serum bilirubin levels should be evaluated for UTI.
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