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The pathological jaundice in neonates develops due to hematological, infectious, surgical causes. We present an interesting case of persistent neonatal hyperbilirubinemia, who was diagnosed to have urinary tract infection (UTI) and effectively managed. Unexplained persistent neonatal jaundice, poor response to phototherapy, and higher rebound total serum bilirubin levels should be evaluated for UTI.
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http://dx.doi.org/10.25259/IJN_209_2024 | DOI Listing |
Pediatr Surg Int
September 2025
Department of Pediatric Surgery, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, 100020, China.
Purpose: Biliary atresia (BA) patients presenting after 90 days of age face contentious treatment decisions between Kasai portoenterostomy and direct liver transplantation. This study evaluated outcomes of Kasai portoenterostomy in older BA patients to inform therapeutic decision-making.
Methods: A retrospective multicenter study analyzed 32 BA patients who underwent Kasai portoenterostomy beyond 90 days of age.
Asian Biomed (Res Rev News)
August 2025
Department of Neonatology, University of Health Sciences Ankara Training and Research Hospital, Ankara 06230, Turkey.
Background: Transcutaneous bilirubinometers provide a non-invasive method to estimate total serum bilirubin (TSB) using multiwavelength reflectance. However, their accuracy during phototherapy (PT) remains controversial due to decreased dermal bilirubin.
Objective: To assess the correlation between TSB and transcutaneous bilirubin (TcB) measured from covered and exposed skin areas before, during, and after PT.
Front Cell Infect Microbiol
September 2025
Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
The neonatal period is a critical stage for microbial colonization and immune system development, with dynamic changes in the microbiome closely linked to the pathogenesis of various diseases. Traditional microbiological testing methods have low sensitivity and time-consuming limitations compared to metagenomic next-generation sequencing (mNGS), which makes it difficult to meet the diagnostic and therapeutic needs of critically ill neonates. mNGS analyzes the total DNA in a sample without bias, allowing comprehensive identification of bacteria, viruses, fungi, and parasites, and resolution of functional genes, providing new avenues for precision diagnosis and treatment of diseases such as neonatal sepsis, necrotizing enterocolitis, neonatal pneumonia, neonatal meningitis, neonatal jaundice, and other diseases.
View Article and Find Full Text PDFIndian J Nephrol
July 2024
Department of Pediatrics, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
The pathological jaundice in neonates develops due to hematological, infectious, surgical causes. We present an interesting case of persistent neonatal hyperbilirubinemia, who was diagnosed to have urinary tract infection (UTI) and effectively managed. Unexplained persistent neonatal jaundice, poor response to phototherapy, and higher rebound total serum bilirubin levels should be evaluated for UTI.
View Article and Find Full Text PDFActa Med Philipp
July 2025
Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila.
Objective: Phenobarbital is an inductor of microsomal hepatic enzyme and used as choleretic for cholestatic liver disease to enhance bile flow. It is also used as a premedication for hepatobiliary scintigraphy (HIDA) scan to improve diagnostic accuracy for an obstructive liver disease. We reviewed the available literature on the use of Phenobarbital for treatment of cholestasis and its utility as a premedication for HIDA scan.
View Article and Find Full Text PDF