Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E (eIF4E).

Scalable and cost-effective CAR-T exosome therapies: challenges and future directions.

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized hematological cancer treatment but faces challenges in solid tumors, including poor infiltration, cytokine release syndrome (CRS), and toxicity. CAR-T cell-derived exosomes (CAR-T exosomes) offer a promising alternative by inheriting CAR-mediated targeting and cytotoxic molecules (e.g.

ECM-based molecular subtypes define prognostic, EMT status, and therapeutic diversity in IDH-mutant gliomas.

IDH-mutant gliomas show prognostic heterogeneity despite favorable overall outcomes, necessitating refined molecular classification. While the extracellular matrix (ECM) critically regulates tumor progression, immunity, and EMT, its prognostic significance in IDH-mutant gliomas remains largely unexplored. Here, we employed unsupervised clustering of ECM-related genes across multiple glioma cohorts, identifying two distinct molecular subtypes: ECM1 and ECM2.

Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial.

Introduction: Overactivation of the sympathetic nerve system can lead to a sustained increase in heart rate, which may impair blood perfusion and organ function. Previous studies have demonstrated that the use of -blockers like esmolol can reduce heart rate, thereby improving clinical outcomes in patients with septic shock. For acute pancreatitis (AP), which shares a similar inflammatory pathophysiology with sepsis, previous experimental and observational studies showed significant sympathetic excitation during the acute phase, and the use of -blockers might be clinically beneficial.

Diagnostic Use of High-Frequency Ultrasound in Differentiating Benign and Malignant Pigmented Skin Lesions.

Objective: This study aims to assess the clinical utility of high-frequency ultrasound in the preoperative differentiation of benign and malignant pigmented skin lesions.

Methods: A cohort of 126 patients with pigmented skin lesions who underwent high-frequency ultrasound examination and subsequent surgical treatment at the First Affiliated Hospital of Henan University of Science and Technology between October 2022 and July 2024 were included in this prospective study. Pathological findings served as the reference standard, and the clinical and ultrasonographic features of benign and malignant pigmented skin lesions were compared.

Extraction, Structural Characteristics, and Antioxidant Activity of a Glucose-Dominated Polysaccharide, NJPW, Purified from (D.Don) DC. .

With the hypothesis that polysaccharides (NJPs) could be the functional constituent contributing to the pharmacological effects of , this study comprehensively examined the extraction approach, chemical characteristics, and antioxidant activities of the polysaccharide from . An ultrasonic-assisted extraction method was developed, with the critical optimum parameters determined as follows: ultrasonic temperature at 64 °C, solid-liquid ratio of 1:45, and ultrasonic time of 52 min. Through purification, a pure polysaccharide (NJPW) was obtained, and its structure was characterized.

Enhanced ferroptosis by light-triggered biomimetic nano-erythrocyte membranes for tumor synergistic therapy.

Breast cancer is the most prevalent fatal cancer among women worldwide and the leading cause of death for women. Ferroptosis is a form of programmed cell death that relies on iron and is non-apoptotic, triggered by the inhibition of the cellular antioxidant system. Photodynamic therapy (PDT) employs photosensitizers to produce reactive oxygen species (ROS), increasing oxidative stress in tumor cells.

The antibody-drug conjugate SHR-A1904 for targeting CLDN18.2 in advanced gastric or gastroesophageal junction cancer: a phase 1 trial.

Claudin-18 isoform 2 (CLDN18.2), a tight junction protein expressed in non-malignant gastric epithelium and exposed on tumor cell surface during malignant transformation, is a promising therapeutic target for gastric and gastroesophageal junction (G/GEJ) cancers. SHR-A1904 is an antibody-drug conjugate comprising CLDN18.

The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.

Background: Idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune diseases with variable long-term outcomes.

Objective: To determine the prognosis of IIM.

Methods: This multicenter, prospective cohort study included Chinese patients with IIM.

Autophagy induced by Porphyromonas gingivalis aggravates esophageal squamous cell carcinoma via YAP/TAZ-miR-21-5p axis.

Porphyromonas gingivalis (P. gingivalis), a keystone pathogen in adult periodontitis, is linked to an increased risk of many cancers. Although autophagy stimulated by P.

Dual-responsive zwitterionic nanogels with synergistic charge reversal and hypoxia-activated drug release for precise tumor targeting and enhanced chemotherapy.

Developing nanomedicine delivery systems that respond to endogenous stimuli from the tumor microenvironment for the precise tumor targeting and controlled release of chemotherapeutic drugs has become a promising candidate to enhance cancer therapy. Here, we designed a zwitterionic nanogel system (named PMm) with charge-switchable and hypoxia-responsive properties for tumor targeting and on-demand drug release. PMm was synthesized through precipitation polymerization, strategically integrating a sulfamide-quaternary ammonium zwitterionic monomer (MPTA) and an azobenzene (azo) based crosslinker (MEFA).

Plasma proteins and different onset subtype of COPD: Proteome-wide Mendelian randomization study and co-localization analyses.

Several studies have reported a strong association between plasma proteins and chronic obstructive pulmonary disease (COPD). However, the directionality and causality of the association and whether proteins effected COPD remain unclear. Therefore, we used Proteome-wide Mendelian randomization (MR) study and co-localization analyses to estimate the casual relationship between them.

Endoplasmic Reticulum-Targeted Photodynamic Therapy Combined with Autophagy Inhibition to Enhance Synergistic Immunotherapy for Triple-Negative Breast Cancer.

Activating immunogenic cell death (ICD) represents a promising therapeutic strategy for tumor immunotherapy. However, photodynamic therapy (PDT)-mediated ICD effect is severely limited due to the extremely short half-life and limited diffusion radius of reactive oxygen species (ROS), hindering effective endoplasmic reticulum (ER) stress induction. In addition, targeted therapy of triple-negative breast cancer (TNBC) remains hugely challenging due to the lack of expression of multiple receptors.

Enhancing salt resistance and all-day efficient solar interfacial evaporation of antibacterial sodium alginate-based porous hydrogels via surface patterning.

The fully bio-based solar-driven interfacial evaporator offers the advantage of being environmentally friendly, but achieving efficient evaporation throughout the day, good salt resistance, and excellent antibacterial properties remains a significant challenge. In this study, a fully bio-based porous hydrogel with a core-shell structure was prepared using sodium alginate (SA) as the matrix and pulp fiber (PF) as the reinforcing material. Crosslinking SA with Cu ions imparts excellent antibacterial properties to the evaporator.

Strategies to overcome the limitations of current organoid technology - engineered organoids.

Organoids, as 3D in vitro models derived from stem cells, have unparalleled advantages over traditional cell and animal models for studying organogenesis, disease mechanisms, drug screening, and personalized diagnosis and treatment. Despite the tremendous progress made in organoid technology, the translational application of organoids still presents enormous challenges due to the complex structure and function of human organs. In this review, the limitations of the translational application of traditional organoid technologies are first described.

The Effect of Aging Time at 600 °C on Tensile Properties of the 0.3Nb FeCrAl Alloy.

This study examines the impact of aging at 600 °C on the tensile properties of 0.3NbFeCrAl alloy at various temperatures, including room temperature (RT), 300 °C, 350 °C, and 400 °C, as well as the corresponding changes in microstructure. Results demonstrate that as aging time increases, the grain size remains relatively stable, while the amount of precipitate gradually increases and becomes uniformly distributed.

Effects of milling degree on proximate composition, functional components and antioxidant capacity of foxtail millet.

The effects of milling degree on proximate compositions, phytic acid (PA), -aminobutyric acid (GABA), phenolics and antioxidant capacity of foxtail millet, as well as color characteristics, were investigated. As milling degree increased, the percentage of total starch content increased continuously, while the total protein, crude fat, total carotenoid and PA contents of foxtail millets increased firstly and then decreased. For the whole milling process, the total ash and GABA contents, total phenolic content (TPC) and total flavonoid content (TFC) of foxtail millet decreased with varying degree.

PEGylated PAMAM dendrimer nanoplatform for co-delivery of chemotherapeutic agents and inorganic nanoparticles enhancing chemo-photothermal combination therapy.

Chemo-photothermal combination therapy has emerged as an important approach for enhancing therapeutic efficacy against tumors. However, developing a flexible nanoplatform capable of co-encapsulating inorganic photothermal agents (PTAs) and organic antitumor drugs remains challenging. A polyethylene glycol-functionalized polyamidoamine (PAMAM) dendrimer (PAMAM-PEG) served as a template for the synthesis of copper sulfide (CuS) nanoparticles and subsequent encapsulation of doxorubicin (DOX) within its inner cavities.

Ultrasound-assisted fermentation effectively alleviates the weakening of wheat gluten network caused by long-chain inulin and the underlying mechanism.

The main objective of the article is to elucidate the effects of ultrasonic treatment with different ultrasonic power (0 W, 200 W, 250 W, 300 W, 400 W and 500 W) on the rheology, water distribution, sulfhydryl disulfide bond content, microstructure, and gluten properties of FXL (Long-chain inulin) dough. When the ultrasonic power is 300 W, the protein polymerization can be promoted, thus improving the gluten network. The mechanical action and cavitation induced by ultrasound changed the water distribution of FXL dough and promoted the transition from weakly bound water to tightly bound water.

Effects of phosphorylation-modified long-chain inulin on wheat starch: Physicochemical properties and retrogradation behaviors.

In this research, modification of long-chain inulin (FXL) through phosphorylation (PFXL) to enhance its application in wheat starch (WS) and starch-based products. The impacts of PFXL on the pasting, rheology, microstructure, and retrogradation characteristics of WS were researched. The findings revealed that PFXL significantly reduced both the breakdown and setback values of WS.

Ivarmacitinib, a selective Janus kinase 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis and inadequate response to conventional synthetic DMARDs: results from a phase III randomised clinical trial.

Objective: To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).

Methods: Patients were randomised (1:1:1) to receive either placebo (n=188), ivarmacitinib 4 mg (n=189) or ivarmacitinib 8 mg (n=189) once daily, with background csDMARDs allowed. After 24 weeks, patients on placebo switched to ivarmacitinib 4 mg for an additional 28 weeks, while those on ivarmacitinib continued their initial dosage.

Rezivertinib versus gefitinib as first-line therapy for patients with EGFR-mutated locally advanced or metastatic non-small-cell lung cancer (REZOR): a multicentre, double-blind, randomised, phase 3 study.

Background: This study aimed to compare the efficacy and safety of rezivertinib (BPI-7711) and gefitinib as first-line therapies in patients with EGFR-mutated locally advanced or metastatic non-small-cell lung cancer (NSCLC).

Methods: This multicentre, double-blind, randomised, phase 3 study (REZOR) included eligible patients from 50 hospitals across China. Those who had been histologically or cytologically confirmed as having NSCLC with EGFR exon 19 deletion or exon 21 Leu858Arg mutation by central laboratory were randomly assigned (1:1) to receive once daily either rezivertinib 180 mg or gefitinib 250 mg, until unacceptable toxicity occurred, disease progression, or other treatment discontinuation criteria were met.

Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study.

Concurrent inhibition of angiogenesis and immune checkpoints represents a potent therapeutic approach. We conducted a phase 2, multicenter, basket study to assess the efficacy and safety of combination therapy of famitinib (anti-angiogenic agent) plus camrelizumab (PD-1 antagonist) in patients with metastatic solid tumors across 11 cohorts (this study was registered at Clinicaltrials.gov [NCT04346381]).

Construction of GOx-loaded metal organic frameworks antibacterial composite hydrogels for skin wound healing.

Bacterial infections and inflammation severely impede wound healing. Here, we developed a zwitterionic hydrogel incorporating MOF/GOx for pH-responsive, controlled drug release. The multifunctional hydrogel embedded with MOF/GOx was successfully prepared through the Schiff base reaction between the copolymer poly[(2-methacryloyloxyethyl phosphorylcholine)-co-(4-formylphenyl methacrylate)] (PMF) and the branched polyethylenimine (PEI) modified by the zwitterionic monomer ((4-hydroxyphenyl)sulfonyl)(4-(trimethylammonio)butanoyl)amide (AB), which possessed excellent injectable and self-healing ability, a highly sensitive and reversible responsiveness to pH changes, and good biocompatibility.

[The multi-center mid-term clinical outcomes of combined complete preservation of chordal structure mitral valve replacement with total anatomic complete arterial myocardial revascularization for coronary patients with moderate-to-severe or severe ischemic mitral regurgitation].

To evaluate the clinical outcomes of combined complete preservation of chordal structure mitral valve replacement (C-MVR) with total anatomical arterial myocardial revascularization (TACR) in coronary patients with moderate-to-severe or severe ischemic mitral regurgitation (IMR). This is a retrospective multi-center case series study. Data were retrospectively collected from 127 patients with coronary artery disease with moderate to severe or severe IMR who received TACR with C-MVR from July 2015 to April 2024 in 13 hospitals in China.