Novel Precursor for h‑BN Synthesis on Ni(111) Substrates.

In this study, we report the synthesis of single-crystalline h-BN on Ni(111) under ultrahigh vacuum (UHV) conditions using hexamethylborazine (HMB) as a nonclassical precursor. The novel use of HMB facilitates the diffusion of methyl groups into the bulk of Ni(111), playing a critical role in the achievement of high-quality crystalline h-BN layers. The synthesis is performed on a 2 mm-thick Ni(111) single crystal and on a 2-μm-thick Ni(111) thin film on sapphire to evaluate the feasibility of synthesizing h-BN on industrially relevant substrates.

Correction: Tuning the spontaneous emission of CdTe quantum dots with hybrid silicon-gold nanogaps.

[This corrects the article DOI: 10.1039/D5RA04583E.].

Mechanical and electronic response of monolayer chromium trihalides CrX (X = Cl, Br, I) under uniaxial strain.

Recent advances in two-dimensional (2D) magnetic materials have promoted significant progress in low-dimensional magnetism and its technological applications. Among them, atomically thin chromium trihalides (CrX with X = Cl, Br, and I) are among the most studied 2D magnets due to their unique magnetic properties. In this work, we employ density functional theory calculations to investigate the mechanical and electronic properties of CrX monolayers in the presence of in-plane uniaxial strain.

Elucidation of the thermo-kinetics of the thermal decomposition of cameroonian kaolin: mechanism, thermodynamic study and identification of its by-products.

This work elucidates the thermo-kinetics of the thermal conversion of cameroonian kaolin to metakaolin as the main product. The thermokinetical parameters (activation energy and pre-exponential factor ) for the kaolin conversion were calculated using model-free methods, the Kissinger-Akahira-Sunrose (KAS) and the Flynn-Wall-Ozawa (FWO) method, and differential methods (Kissinger and Ozawa) additionally including iterative procedures for KAS and FWO methods (KAS-Ir; FWO-Ir). The cameroonian kaolin was heat-treated using three different heating rates, 5, 20 and 40 K min, leading to metakaolin samples named MK-(5), MK-(20) and MK-(40).

Exploring allosteric properties of mammalian ALOX15: octyl (-(4-(benzofuran-2-yl)-2-methoxyphenyl)sulfamoyl)- and octyl (-(4-(1-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates as ALOX inhibitors.

Mammalian ALOX15 are allosteric enzymes but the mechanism of allosteric regulation remains a matter of discussion. Octyl (-(5-(1-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate inhibits the linoleate oxygenase activity of ALOX15 at nanomolar concentrations, but oxygenation of arachidonic acid is hardly affected. The mechanism of substrate selective inhibition suggests inter-monomer communication within the allosteric ALOX15 dimer complex, in which the inhibitor binding to monomer A induces conformational alterations in the structure of the active site of monomer B.

Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder.

This article proposes minimum requirements for reporting efficacy in treatment studies of compulsive sexual behavior (CSB). CSB disorder (CSBD) is a condition whose diagnostic criteria were only recently defined by the World Health Organization. Multiple primary and secondary outcomes have been used in treatment trials of CSB, and possible neuropsychological measures have been considered.

Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit.

Herein we present the rapid development of LH168, a potent and highly selective chemical probe for WDR5, streamlined by utilizing a DEL-ML (DNA encoded library-machine learning) hit as the chemical starting point. LH168 was comprehensively characterized in bioassays and demonstrated potent target engagement at the WIN-site pocket of WDR5, with an EC of approximately 10 nM, a long residence time, and exceptional proteome-wide selectivity for WDR5. In addition, we present the X-ray co-crystal structure and provide insights into the structure-activity relationships (SAR).

Advanced cancer patients' experience and perception of advance care planning at a university teaching hospital in Northern Tanzania.

Background: Advance care planning (ACP) is not formally implemented in Tanzanian healthcare. While the burden of non-communicable diseases continues to rise, most patients present at advanced stages of illness, highlighting the urgent need for ACP to support preference-based care.

Objectives: This study aimed to explore advanced cancer patients' experiences and perceptions of ACP at a university teaching hospital in Northern Tanzania.

RETURN-TO-WORK AFTER ACETABULAR FRACTURES: THE IMPACT OF INJURY SEVERITY ON THE POST-REHABILITATION WORKING CAPACITY AND WORKLOAD.

Objective: Acetabular fractures are among the most severe injuries in trauma surgery. In younger patients, they typically result from high-energy trauma and are often associated with polytrauma. Treatment complexity and rehabilitation outcomes are influenced by overall injury severity.

Psychology's Questionable Research Fundamentals (QRFs): Key problems in quantitative psychology and psychological measurement beyond Questionable Research Practices (QRPs).

Psychology's crises (e.g., replicability, generalisability) are currently believed to derive from Questionable Research Practices (QRPs), thus scientific misconduct.

The Relation of Osteoporotic Vertebral Fractures and Sarcopenic Characteristics on the Occurrence of Complications: A Systematic Review.

Study Design: Systematic review.

Purpose: As the number of elderly increases, age-related changes of body composition like osteoporosis and sarcopenic muscle changes contribute to higher morbidity, less quality of life and higher health care costs. Data on the effect of muscle atrophy on osteoporotic vertebral fractures is limited.

Mutation-based, neoadjuvant treatment for advanced anaplastic thyroid carcinoma.

Introduction: The prognosis of anaplastic thyroid carcinoma (ATC) remains poor. Mutation-based targeted therapies and immune checkpoint inhibitors (ICI) have gained increasing importance in the treatment of advanced tumor stages. This study aimed to investigate whether mutation-based neoadjuvant therapy can convert an initially unresectable tumor into a resectable state, optimizing local tumor control and prolonging overall survival.

3,3'-Linked BINOL macrocycles: optimized synthesis of crown ethers featuring one or two BINOL units.

Chiral macrocycles hold significant importance in various scientific fields due to their unique structural and chemical properties. By controlling their size, shape, and substituents, chiral macrocycles offer a platform for designing and synthesizing highly efficient catalysts, chemosensors, and functional materials. We have recently made strides in developing macrocyclic organocatalysts; however, their synthesis remains challenging.

Oxygen targets in patients with septic shock: a retrospective cohort study on the association between hyperoxia and mortality.

Background: In critically ill patients with septic shock, adequate oxygenation is crucial and hypoxia should be avoided. However, hyperoxia has been linked to the formation of reactive oxygen species, inflammation, and vasoconstriction, which could potentially harm critically ill intensive care patients. Therefore, this study aimed to examine the association between oxygen exposure and mortality and to define optimal oxygen target ranges for this specific group of patients.

Aspects of power sensitivity among social workers and social work students: a comparative study.

The asymmetrical nature of the relationship between social workers and their clients may lead to abuse of power due to a human trait or corruption. A high level of power sensitivity is thus crucial to counteract power abuse. Ideally, this topic should be covered during studies, as the risk of corruption rises with everyday working life.

Analysis of tracrRNAs reveals subgroup V2 of type V-K CAST systems.

Clustered regularly interspaced palindromic repeats (CRISPR)-associated transposons (CAST) consist of an integration between certain class 1 or class 2 CRISPR-Cas systems and Tn7-like transposons. Class 2 type V-K CAST systems are restricted to cyanobacteria. Here, we identified a unique subgroup of type V-K systems through phylogenetic analysis, classified as V-K_V2.

Avalanche transceiver search times during avalanche companion rescue - A prospective randomized single-blinded cross-over simulation study.

Background: The aim of this study was to analyse the influence of voice navigation in a new generation of transceivers on the time and success rate of transceiver search in a simulated avalanche rescue scenario.

Methods: Fifty participants performed two randomized test runs, using two different transmitters with and without voice navigation. Primary outcome was success rate, total transceiver search and total location time, secondary outcome parameters comprised predefined time intervals (coarse search time, fine search time, probing time) and deviations from the recommended standard search procedure.

Low-Energy Electron Irradiation Inactivates Viruses in Serum and Maintains Growth-Promoting Properties in Cell Culture.

Background: Serum and other blood-derived products are widely used in biomedical and biopharmaceutical processes, especially for the production of vaccines or cell therapeutic applications. To ensure quality and safety, each serum lot undergoes testing for sterility to minimize the risk of disease transmission. A currently performed standard procedure is gamma-irradiation of serum for effectively killing pathogens.

Updated Trends in Valvular Heart Disease-Related Heart Failure in G20-the Group of Twenty Countries: Insights From the Global Burden of Disease Study 2021.

Background: Valvular heart disease (VHD), including both non-rheumatic valvular heart disease (NRVHD) and rheumatic valvular heart disease (RVHD), is a major global health concern. Moreover, the progression of VHD to heart failure (HF) poses substantial clinical and public health challenges. In light of the global population aging, alongside increasing cardiovascular risk factors, and the additional strain imposed by the COVID-19 pandemic, a timely reassessment of the VHD-related HF burden is urgently needed.

Photomediated C-H trifluoromethoxylations enabled by bis(trifluoromethyl)peroxide.

We describe a photomediated protocol for the trifluoromethoxylation of benzylic, aldehydic, and non-activated C-H bonds, using bis(trifluoromethyl)peroxide (BTMP, (FCO)) as the key reagent. Under catalyst-free conditions in acetone, this reaction proceeds with selective functionalization of benzylic methylene groups. Furthermore, by using tetrabutylammonium decatungstate as a photocatalyst, the scope extends to include both non-activated methylene C(sp)-H and formyl C(sp)-H bonds.

First light them up: photoresponsive imine-containing systems.

The reversible covalent bond formation that underpins dynamic covalent chemistry (DCC) enables the construction of stimuli-responsive systems and the efficient assembly of complex architectures. While most DCC studies have focused on systems at thermodynamic equilibrium, there is growing interest in systems that operate away from equilibrium-either by shifting to a new free-energy landscape in response to a stimulus, or by accessing an out-of-equilibrium state following an energy input. Imine-based systems are especially attractive due to the accessibility of their building blocks and their dynamic behavior in both condensation and transimination reactions.

Differences and similarities in the chemical bonding of intermetallic phases in the Ca-Al-Pt system.

Intermetallic compounds belong to an important class of materials, not only due to the sheer number of compounds known but also due to their application in everyday life. These compounds possess their very own peculiarities, especially when it comes to chemical bonding. To address this point, bonding analyses based on Crystal Orbital Bond Index (COBI) values, Löwdin charges, and - for the first time - oxidation numbers (ON ) were conducted, all extracted from delocalized plane-wave functions.

The eubiotic perspective on utilization of tannins in phytotherapy and nutrition of pigs.

Gastrointestinal eubiosis is essential for maintaining overall host wellbeing. Post-weaning diarrhea (PWD) is a common issue in pig development, arising from weaning stress, which disrupts the gut microbiota balance and increases susceptibility to infections. The primary bacterial pathogen linked to PWD is enterotoxigenic (ETEC).

Toward more realistic career path prediction: evaluation and methods.

Predicting career trajectories is a complex yet impactful task, offering significant benefits for personalized career counseling, recruitment optimization, and workforce planning. However, effective career path prediction (CPP) modeling faces challenges including highly variable career trajectories, free-text resume data, and limited publicly available benchmark datasets. In this study, we present a comprehensive comparative evaluation of CPP models-linear projection, multilayer perceptron (MLP), LSTM, and large language models (LLMs)-across multiple input settings and two recently introduced public datasets.

Emulating sensation by bridging neuromorphic computing and multisensory integration.

Multisensory perception produces vast amounts of data requiring efficient processing. This paper focuses on the multisensory example of touch in biological and artificial systems. We integrate philosophical theories of multisensory perception with neuromorphic hardware and demonstrate how classical sensory integration concepts can enhance artificial sensory systems.