Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Study Design: Systematic review.
Purpose: As the number of elderly increases, age-related changes of body composition like osteoporosis and sarcopenic muscle changes contribute to higher morbidity, less quality of life and higher health care costs. Data on the effect of muscle atrophy on osteoporotic vertebral fractures is limited. We systematically reviewed the current literature for the influence of preexisting degenerative muscle changes in patients with OVF on the occurrence of complication during and after treatment.
Methods: A systematic literature review adherent to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines was performed using the Web of Science and Medline databases. We considered English and German articles from January 1990 to December 2022. Inclusion criteria covered patients with OVF and muscle degeneration with complications during and after treatment. Included trials were cohort studies and case series.
Results: Eight Studies were included in this systematic review. One studied the role of degenerated paravertebral muscle during conservative treatment. One article analysed the influence of sarcopenia after dorsal instrumentation in patients with OVF, another the effects of muscle degeneration after dorsal instrumentation or kyphoplasty. The other studies evaluated complications after percutaneous vertebroplasty or kyphoplasty. Seven studies described an increased risk for subsequent fracture following OVF treatment in case of muscle degeneration, despite differing methods and cut-offs for muscle degeneration.
Conclusion: Subsequent fractures were the most frequently analysed complication, others were scarcely analysed. Most studies found a correlation of paravertebral muscle degeneration and the occurrence of secondary OVFs. However, very different methods and cut-offs for sarcopenia assessment were used and it remains unclear what defines muscle changes that lead to an increased risk for complications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415093 | PMC |
| http://dx.doi.org/10.2147/CIA.S532935 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis.
Cell Commun Signal
September 2025
Department of Cytology, Institute of Anatomy, Medical Faculty, Ruhr-University Bochum, Universitätsstr. 150, Building MA 5/52, Bochum, 44801, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.
Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.
Precise measurement of motor neuron dysfunction in Drosophila ALS model via climbing assay and leg imaging.
Methods Cell Biol
September 2025
The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, P.R. China; Medical and Health Research Institute, Zhengzhou Research Institute of HIT, Zhengzhou, HA, P.R. China. Electronic address:
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle weakness, paralysis, and death. While there is a plethora of studies focusing on many aspects of ALS, the pathogenesis of this disease is not well understood, and effective treatments are scarce. Drosophila melanogaster is a powerful model organism for studying ALS due to its genetic tractability and its evolutionarily conserved cellular and molecular processes which are also shared between the fly and human.
View Article and Find Full Text PDFThe Relation of Osteoporotic Vertebral Fractures and Sarcopenic Characteristics on the Occurrence of Complications: A Systematic Review.
Clin Interv Aging
September 2025
Department for Orthopedics, Traumatology and Plastic Surgery, University Hospital, Leipzig, Germany.
Study Design: Systematic review.
Purpose: As the number of elderly increases, age-related changes of body composition like osteoporosis and sarcopenic muscle changes contribute to higher morbidity, less quality of life and higher health care costs. Data on the effect of muscle atrophy on osteoporotic vertebral fractures is limited.
Facial nerve pathology: emerging strategies for regeneration and functional restoration.
J Mater Chem B
September 2025
Nebraska Translational Research Center (NTRC), Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Joseph D. & Millie E. Williams Science Hall, 525 S 42nd St, Room No 3.0.010, Omaha, NE 68105-6040, USA.
Facial nerve injuries cause significant functional impairments, affect facial expressions, speech, and overall quality of life. This article explores advances in facial nerve regeneration, encompassing both conventional and emerging therapeutic strategies. The regenerative process involves Wallerian degeneration, axonal regrowth, and target muscle reinnervation, where the distal axon degrades and the proximal axon initiates sprouting to restore connectivity.
View Article and Find Full Text PDFEvaluation of Cartilage Degeneration Using MRI T1ρ Mapping after Locomotion Training in Patients with Early Knee Osteoarthritis.
Prog Rehabil Med
September 2025
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Objectives: : This study aimed to assess the qualitative effects of locomotion training (LT) on articular cartilage using magnetic resonance imaging T1ρ mapping.
Methods: : Fifteen patients with early knee osteoarthritis participated in the study. They performed a series of exercises, including one-leg stands, squats, heel raises, and front lunges, on a daily basis for 12 weeks.