Revolutionizing Drug Delivery: The Promise of Self-emulsifying Systems in Overcoming Bioavailability Challenges.

Introduction: The oral route is a preferred method for drug administration; however, lipophilic drugs often suffer from poor water solubility, significantly limiting their therapeutic effectiveness. Traditional approaches like complexation, micronization, and solid dispersion have been explored, but each comes with inherent limitations.

Methods: Self-Emulsifying Drug Delivery Systems (SEDDS) have emerged as a promising strategy to address solubility challenges.

Nanotherapeutics Mediated Intranasal Delivery for Therapeutic Effect on Parkinson's Disease: Balancing Advancements and Challenges.

Managing Parkinson's Disease (PD) presents formidable challenges due to the impermeability of the Blood-Brain Barrier (BBB), which severely restricts effective drug delivery. Traditional treatment modalities often prove inadequate, prompting the exploration of intranasal drug delivery as a novel and promising alternative. This innovative approach provides direct access to the central nervous system while bypassing the Blood-Brain Barrier (BBB).

Advances in cancer therapy using fluorinated chitosan: a promising nanoplatform for drug delivery.

Chitosan, a naturally derived polysaccharide, has gained considerable attention as a biomaterial for drug delivery due to its excellent biocompatibility, biodegradability, and mucoadhesive properties. However, its limited solubility and compatibility with hydrophobic drugs restrict broader applications. Recent advances in the chemical modification of chitosan specifically through fluorination have significantly improved its performance in nanomedicine.

Optimizing meningioma grading with radiomics and deep features integration, attention mechanisms, and reproducibility analysis.

Objective: This study aims to develop a robust and clinically applicable framework for preoperative grading of meningiomas using T1-contrast-enhanced and T2-weighted MRI images. The approach integrates radiomic feature extraction, attention-guided deep learning models, and reproducibility assessment to achieve high diagnostic accuracy, model interpretability, and clinical reliability.

Materials And Methods: We analyzed MRI scans from 2546 patients with histopathologically confirmed meningiomas (1560 low-grade, 986 high-grade).

Application of response surface methodology for modeling adsorption of janus green and safranin-O on magnetic nanocomposite from aqueous solutions.

The presence of dyes in water bodies has become a significant concern in recent years. In this study, a magnetic nanocomposite synthesized from activated carbon (AC) and FeO nanoparticles (AC/FeO) was employed as an adsorbent to remove janus green (JG) and safranin-O (SO) dyes. The AC/FeO nanocomposite had particle sizes smaller than 100 nm.

Computation drug design for ACE inhibitor for high blood pressure management and assessment of pharmacokinetics and toxicity of promising compounds isolated from Gymnema sylvestre.

This study employs computational drug design approaches to identify and optimize ACE inhibitors from G. sylvestre's isolated compounds, assessing their pharmacokinetic and toxicity profiles. The receptor (PDB: 1o86) was retrieved from RCSB, prepared, and analyzed for active binding sites.

Construction of Hierarchical Star Like Morphology of NiO Nanosheets Having Superb Peroxidase Mimetic Properties for Effective Colorimetric HO Sensing.

In this work, we have developed a novel and sensitive colorimetric sensor by the constructions of hierarchical star-like structure of exfoliated NiO called as NiO-ɤ catalyst with strong peroxidase mimetic properties. The as prepared sensor predicted highest sensing response with wider and linear range of 0.001-0.

Influence of ceramic thermal barrier coating on diesel engine performance using scum oil biodiesel at different compression ratios.

The present work explores the synergistic impact of mullite-based thermal barrier coatings (TBCs) and varying compression ratios (CRs) on the performance, combustion, and emission behavior of a single-cylinder, four-stroke variable compression ratio (VCR) diesel engine operated with Scum Oil Methyl Ester (SOME) diesel fuel blends. Mullite ceramic (3AlO·2SiO) was applied via plasma spraying onto engine components including the piston crown, cylinder head, and intake/exhaust valves to minimize thermal losses. Experimental tests were carried out at CRs of 16.

Novel PLA-Henna composite for sustainable tertiary enhanced oil recovery.

Enhanced oil recovery (EOR) remains a critical focus for the petroleum industry, aiming to overcome the challenges of residual oil mobilization and maximize hydrocarbon recovery in increasingly complex reservoirs. This study introduces an innovative approach using synthesized Polylactic Acid (PLA)/Henna composites as an environmentally sustainable additive to enhance oil recovery through mechanisms such as interfacial tension (IFT) reduction, wettability alteration, and physical sweeping for improved fluid sweep efficiency. The composite was synthesized using extrusion techniques to ensure a uniform filler dispersion and was extensively characterized through FTIR, SEM, and EDS analyses.

Hybrid pre trained model based feature extraction for enhanced indoor scene classification in federated learning environments.

Classification of indoor scenes is a crucial task of computer vision. It has widespread applications like smart homes, smart cities, robotics, etc. Primitive classification methods like Support Vector Machines (SVM) and K-Nearest Neighbors (KNN), provide a compromised performance with complex indoor environments due to light variations, intra-class similarities, and occlusions.

Synthesis of an efficient MOF heterogeneous catalyst (UiO-66-NH-Pd) for C-O cross-coupling reactions.

This study successfully encapsulated palladium nanoparticles within the metal-organic framework material UiO-66 using a straightforward method. Utilizing a microwave-assisted process, the pores of UiO-66 were activated, and the metal precursors were simultaneously reduced in the presence of a reducing agent. The morphological and physicochemical properties of the resulting material were thoroughly analyzed using various techniques, including EDX, SEM, XRD, TGA, BET, and ICP-OES.

Towards Sustainable Agarwood Production: Integrating Microbial Interactions, Anatomical Changes, and Metabolite Biosynthesis.

Agarwood is a highly valuable non-timber forest product mainly derived from the Aquilaria genus, widely traded in the perfumery, religious items, and traditional medicine industries. Naturally, agarwood forms within the xylem as part of the tree's defense mechanism against environmental stressors and microbial infection. The escalating demand for agarwood has led to the overexploitation of Aquilaria species, with some now classified as critically endangered.

Magnetic agar-cellulose hydrogel/g-C₃N₄/ZnAl LDH@Fe₃O₄ nanocomposite for efficient pirimicarb removal and antibacterial water purification.

This study focused on the development and application of a highly effective magnetic porous nanocomposite for the adsorption of pirimicarb, a carbamate pesticide commonly used for aphid control. This nanocomposite was prepared using agar, cellulose, graphitic carbon nitride, and ZnAl layered double hydroxide (Agar-Cellulose hydrogel/g-CN/Zn-Al LDH@FeO), and was characterized using various techniques, including FT-IR, XRD, SEM, VSM, and TGA. Optimization using response surface methodology (RSM) identified the best conditions as pH 7.

Dual inhibition of AXL and MER kinase: scope for lung and breast cancer therapeutics.

Cancer cells use multiple survival pathways for continuous proliferation, survival, and growth. Recent anticancer drug discovery commonly focuses on a single target that maintains key cancer cell survival mechanisms, where typically, this is a cellular enzyme that inhibits DNA replication, inducing cell damage and apoptosis. Since drugs that act on a single target may be more susceptible to the development of resistance, the search for polypharmacotherapeutics is becoming increasingly popular to defeat drug-resistant cancer cells.

Employing a drug repurposing strategy to identify B-cell lymphoma-2 (BCL-2) inhibitors with anticancer potential: An in silico and in vitro based study.

BCL-2 (B-cell lymphoma-2) is a key protein overexpressed in numerous cancers. Further, its association with cancer cell survival, prognosis, and ability to evade apoptosis makes it an important drug target in cancer chemotherapy. Venetoclax (ABP199) is the only FDA-approved BCL-2 inhibitor for chronic lymphocytic leukemia (CLL).

Optimized Formulation of Sulfasalazine and Probiotic-Loaded Carrageenan Microparticles Using Design of Experiments for Effective Colitis Management.

Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by mucosal inflammation and epithelial barrier dysfunction. Sulfasalazine, a standard antiinflammatory drug, and probiotics, known for gut microbiota modulation, have both shown efficacy in UC management. However, their combined delivery to the colon remains underexplored.

The Bidirectional Relationship between Psoriatic Arthritis and Mental Health: A Comprehensive Review.

Introduction: Psoriatic arthritis (PsA) is a long-standing inflammatory immune-mediated condition that involves articular and peri-articular tissues and frequently accompanies psoriasis (PsO). It is defined by chronic joint inflammation, pain, and structural damage, resulting in impairment of physical function and quality of life. Increasing evidence points to the close relationship between PsA and mental disorders, especially depression and anxiety.

Harnessing exosomal mediators for advanced wound healing: Mechanisms and therapeutic potential in angiogenesis.

Angiogenesis is critical for effective wound healing, supplying oxygen and nutrients to regenerating tissues. In chronic conditions like diabetes, impaired angiogenesis leads to delayed healing, chronic wounds, and significant healthcare burdens. Exosomes, nano-sized extracellular vesicles derived from cells such as mesenchymal stem cells (MSCs), amniotic epithelial cells, and keratinocytes, have emerged as key mediators in promoting angiogenesis.

Exploring SLAMF5/CD84 in Cancer: Advancing the Frontiers of Tumor Immunology.

The Signaling Lymphocytic Activation Molecule (SLAM) family receptors play essential roles in regulating immune cell activation, differentiation, and communication. SLAMF5, also known as CD84, has drawn increasing attention in cancer immunology due to its involvement in both tumor progression and immune modulation. This review explores the expression patterns, signaling mechanisms, and functional roles of SLAMF5/CD84 within the tumor microenvironment.

Quantum Dots in Neurotheranostics for the Treatment of Alzheimer's Disease.

Age-related neurodegeneration is one of the primary causes associated with the pathogenesis of Alzheimer's disease (AD). Currently, there are 5.8 million cases of AD worldwide.

Advancing multifunctional carbon fibre composites: the role of nanomaterials in boosting electrochemical performance for energy storage.

Carbon fibre composites (CFCs) hold significant promise for energy storage and harvesting applications owing to their exceptional strength-to-weight ratio and structural versatility, but their electrochemical performance is constrained by inherent limitations such as low surface area and restricted ion transport pathways. This review examines how strategic integration of nanomaterials-including graphene, carbon nanotubes and MXenes-can overcome these challenges by enhancing surface reactivity, improving electrical conductivity and facilitating efficient ion diffusion, thereby enabling high-performance multifunctional composites. We discuss key advances in nanomaterial-incorporated CFCs for structural batteries and supercapacitors, where tailored interfaces and hierarchical architectures contribute to superior energy and power densities, as well as their emerging role in integrated energy harvesting systems that combine energy storage with triboelectric, piezoelectric or thermoelectric conversion capabilities.

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies.

The roots of the genus, specifically and related species, contain natural plumbagin. Because of its possible medicinal benefits, naphthoquinone has been the subject of several studies. Ongoing research aims to better understand the mechanisms underlying the actions of plumbagin, optimize its distribution and formulation, assess its efficacy and safety in clinical trials.

Gold-Containing Compound Auranofin Ameliorates 6-OHDA Induced Neurotoxicity in Rats: Via Targeting PI3K/Akt/GSK-3β Signalling.

The prevalence of parkinsonism is increasing worldwide, not only in age groups but now becoming a favourite of adults. As the onset is increasing in developed and underdeveloped countries, the current therapy lacks a permanent cure. Therefore, the research has used the gold-containing compound auranofin (AUF) in its neuroprotective form.