The Bidirectional Relationship between Psoriatic Arthritis and Mental Health: A Comprehensive Review.

Introduction: Psoriatic arthritis (PsA) is a long-standing inflammatory immune-mediated condition that involves articular and peri-articular tissues and frequently accompanies psoriasis (PsO). It is defined by chronic joint inflammation, pain, and structural damage, resulting in impairment of physical function and quality of life. Increasing evidence points to the close relationship between PsA and mental disorders, especially depression and anxiety.

4D-printed multifunctional hydrogels as flexible strain sensors and nerve conduits.

Conductive hydrogels are critical for advanced bioelectronics and the repair of electroactive tissues. However, developing conductive hydrogels into complex biomimetic shapes with good flexibility and bioactivity poses a major biofabrication challenge. This study utilizes dual-component hydrogel inks based on alginate incorporating conductive fCNT (acid-functionalized carbon nanotube) nanofillers, with the composite gel exhibiting an electrical conductivity of 6.

The Fragile Balance: Autophagy's Role in Neurodegenerative Disease Progression.

Autophagy relates to the mechanism underlying the intracellular constituents' breakdown by lysosomes. Autophagy plays an essential role in preserving and regulating cellular homeostasis by mediating the degradation of intracellular components and recycling their decomposition products. It was demonstrated that autophagy operates in-vivo in the starving reaction, initial growth, internal control of quality, and cell division.

Development and In-vitro Optimization of Telmisartan-Curcumin Solid Dispersion Nanoparticles for the Management of Diabetic Nephropathy Using DoE Approach.

Objectives: This study aimed to develop and optimize Telmisartan-Curcumin Solid Dispersion Nanoparticles (SDNs) to improve the management of diabetic nephropathy by enhancing Telmisartan's solubility and release rate.

Methods: A Box-Behnken design was used to optimize the formulation with critical excipients PVP VA S630 and Poloxamer 407. Pre-formulation studies assessed Telmisartan's solubility and lipophilic nature.

Targeting neurotrophic dysregulation in diabetic retinopathy: a novel therapeutic avenue.

The gradual retinal damage caused by chronic hyperglycemia is known as Diabetic retinopathy (DR), and it is the main cause of visual impairment and blindness in adults. The importance of neurotrophic factors in DR pathogenesis has been emphasized by recent studies. In diabetes, several naturally occurring proteins undergo substantial changes that impact neuronal survival, development, and differentiation.

Beyond the Surface: The Role of Implantable Drug Delivery Systems in Modern Medicine.

Advanced drug delivery methods have emerged mainly because of the limitations of traditional drug delivery systems like oral and intravenous routes, along with fluctuating concentrations of drugs that have compromised therapeutic outcomes. An implantable drug delivery system (IDDS) presents an attractive alternative: long-term, continuous drug release improves therapeutic efficacy while minimizing toxicity and side effects. IDDS, first presented in the 1930s as subcutaneous hormone pellets, have gained much attention recently in drug delivery due to their controlled release of drugs in a localized and sustained manner.

Antimicrobial peptides: a promising frontier to combat antibiotic resistant pathogens.

Antimicrobial peptides (AMPs) are varied naturally occurring compounds that are crucial to the innate immune system among several organisms. These peptides are effective against various bacteria, viruses, fungus, and cancer cells. Alternative therapeutic options are becoming more important as drug-resistant diseases become a global concern nowadays.

Flavonoids and flavonoid-based nanoparticles for the treatment of arthritis.

Arthritis is an autoimmune disorder that predominantly causes inflammation and impacts peripheral joints. Even though immunosuppressive and NSAIDs or non-steroidal anti-inflammatory medicines are implemented for the management of this disorder, sbut they carry some severe side effects along with them. Therefore, society requires treatment with fewer side effects and powerful anti-arthritic properties, such as flavonoids.

Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and Bacopa Monnieri for Accelerated Peripheral Nerve Regeneration.

Peripheral nerve injuries (PNIs) often lead to semi or complete loss of motor, sensory and autonomic functions. Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative.

Serotonergic Dynamics in Autism Spectrum Disorder: Unraveling the Intricate Connection.

Autism Spectrum Disorder (ASD) constitutes a group of neurodevelopmental disorders characterized by impairments in verbal and nonverbal communication skills, social interactions, and stereotypes of behavior, with an estimated frequency of 1.2% of children throughout the world. The lack of specific treatments or molecular biomarkers underscores the complexities of ASD as a nonunified clinical entity.

Potential role of NSAIDs loaded nano-formulations to treat inflammatory diseases.

Inflammation is a necessary immunological response that promotes survival and preserves tissue homeostasis, a common characteristic linked to various diseases. However, in some circumstances, the inflammatory response is deleterious and contributes to disease pathogenesis. Anti-inflammatory substances have poor affinity for inflamed tissues, resulting in low concentrations in the target tissue and a higher incidence of severe adverse effects.

Transdermal Drug Delivery Systems: Integrating Modern Technology for Enhanced Therapeutics.

Background: In recent years, transdermal drug delivery systems (TDDS) have gained popularity as a non-invasive, patient-friendly medication delivery method.

Objective: This review article examines the latest transdermal medication delivery developments and breakthroughs. The review begins with a brief summary of transdermal medication administration, stressing the skin's barrier role and drug permeation methods.

Recent Updates on Antibacterial Quinolones: Green Synthesis, Mode of Interaction and Structure-Activity Relationship.

Quinolone antibiotics are a crucial class of synthetic antibacterial agents, widely utilized due to their broad spectrum of antibacterial activity. Due to the development of antimicrobial resistance, the potency of quinolone drugs decreased. Many conventional methods have been developed to elevate amination rate and to improve yield.

Mechanistic insights and therapeutic potential of astilbin and apigenin in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) represents a critical complication of Diabetes mellitus (DM), characterized by structural and functional changes in the myocardium independent of coronary artery disease or hypertension. Emerging evidence highlights the significant roles of phytochemicals, particularly astilbin and apigenin, in modulating key molecular pathways implicated in DCM. This review synthesizes current mechanistic insights and therapeutic potential of these compounds, focusing on their interactions with AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs), O-linked N-acetylglucosamine (O-GlcNAc), sodium-glucose co-transporter 2 (SGLT2), protein kinase C (PKC), nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) pathways.

Vincristine in Cancer Therapy: Mechanisms, Efficacy, and Future Perspectives.

Cancer remains one of the predominant causes of mortality globally, accounting for over 10 million deaths each year. Despite advancements in medical treatments, the challenge of resistance and treatment failure persists, necessitating innovative approaches. Traditional cancer treatments include surgery, chemotherapy, radiation therapy, and pharmaceutical therapy.

Exploring therapeutic potential: Targeting TRPM7 in neurodegenerative diseases.

The ions Ca and Mg, which are both present in the body, have been demonstrated to be crucial in the control of a variety of neuronal processes. Transient melastatin-7 (TRPM7) channel plays an important role in controlling Ca and Mg homeostasis, which is crucial for biological processes. The review will also examine how changes in TRPM7 function or expression can lead to neurodegeneration.

Exploring the potential of an and honey extract loaded bi-layered nanofibrous scaffold of PCL-Col and PCL-SBMA mimicking the skin architecture for the treatment of diabetic wounds.

Diabetic wounds are often chronic in nature, and issues like elevated blood sugar, bacterial infections, oxidative stress and persistent inflammation impede the healing process. To ensure the appropriate healing of wounds, scaffolds should promote complete tissue regeneration in wounds, both functionally and structurally. However, the available scaffolds lack the explicit architecture and functionality that could match those of native skin, thus failing to carry out the scar-free skin regeneration in diabetic wounds.

In Silico and In Vivo Evaluation of Anti-Arthritic Effects of Bakuchiol from Psoralea corylifolia Seeds in Experimental Rat Model.

Rheumatoid arthritis is an autoimmune disease mainly affecting the joints categorized by inflammation, swelling of the synovium and decrease in the joint movement. Bakuchiol, a meroterpene class of natural product present in Psoralea corylifolia known to possess anti-inflammatory effects by a variety of mechanisms. However, its effects in rheumatoid arthritis still remain unclear.

Preclinical pharmacology and pharmacokinetics of curcumin tagged cilostazol nanodispersion for the management of diabetic nephropathy in wister rat model.

To evaluate the therapeutic potential of curcumin tagged cilostazol solid nano dispersion in wistar rat streptozotocin-nicotinamide-induced diabetic nephropathy. Cilostazol (CLT), a Phosphodiesterase (PDE) inhibitor has an inhibitory effect on reactive oxygen species (ROS), and Curcumin (Cur), an antioxidant, and anti-inflammatory, are water-soluble. Solid Nano dispersions were developed using the "Box-Behnken Design" and emulsion solvent evaporation procedure to improve the solubility and bioavailability.

Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis-Comprehensive Review.

Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible therapeutic agents for RA disease.

Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin.

Neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, and others) and cancer, seemingly disparate in their etiology and manifestation, exhibit intriguing associations in certain cellular and molecular processes. Both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and DNA repair and pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is a flavonoid compound abundant in various plant sources.

Harnessing Bioprinting Technologies for Diabetic Wound Regeneration.

A chronic metabolic condition, diabetes mellitus (DM), is becoming more common all over the globe. Diabetic complications include diabetic foot ulcers (DFUs). Between fifteen and twenty-five percent of people with diabetes will experience DFU at some point in their lives.