Versatility of Surfactant-Mediated NiTe Nanoparticles: Unlocking Potential for Hydrogen Evolution Reaction, Supercapacitor, and Sustainable Green Catalysis.

Designing multifunctional nanomaterials is economically and practically advantageous. Herein, this work reports a surfactant-mediated synthesis of NiTe nanoparticles (NPs) and their applications in electrocatalysis, energy storage, and sustainable green catalysis. The NiTe NPs exhibit excellent hydrogen evolution reaction (HER) activity, with a low overpotential of 309 mV versus RHE at 10 mA cm and a Tafel slope of 50 mV dec, indicating fast kinetics.

Rhodamine and functionalised azobenzene condensed fluorescent novel receptor for the selective and sensitive detection of Hg: a combined experimental and theoretical study.

Rhodamine dye has a high absorption coefficient, fluorescence quantum yield, photostability, and extended wavelengths that make it a promising fluorescent probe. A rhodamine and functionalised azobenzene condensed novel chemosensor L has been reported for the first time to detect Hg in aqueous ethanol optically in this investigation. Chemosensor L's fluorescence activation in response to Hg is due to the suppression of PET and CHEF processes and the change from spirolactam to ring-opened amide.

1,3,4-Thiadiazole Derivatives as VEGFR-2 Inhibitors and Its Molecular Insight for Cancer Therapy.

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a pivotal role in tumor angiogenesis, progression, and metastasis by modulating cell proliferation, migration, and survival via VEGF-mediated signaling. Despite the therapeutic success of current VEGFR-2 inhibitors, their clinical utility is often constrained by acquired resistance, off-target toxicities, and suboptimal selectivity. The 1,3,4-thiadiazole (TDA) scaffold has emerged as a privileged moiety in cancer drug discovery due to its mesoionic character, structural diversity, and molecular pharmacology.

A Review on MOFs as Efficient Fluorometric Chemosensors for Metal Ions.

MOFs are extensively utilized for recognizing metal ions. With their tunable structures, opportunities for postsynthetic modification, and chemical stability, MOFs outperform current alternatives by providing unique spectroscopic readings for metal ion detection. We find their recyclability particularly appealing, as it allows repeated use of the same host probe-this aspect is crucial for point-of-care technologies.

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma.

Angiogenesis plays a key role in the development and progression of renal cell carcinoma (RCC). Actin-binding protein profilin-1 (Pfn1) is overexpressed in clear cell RCC predominantly in tumor-associated vascular endothelial cells (ECs). We previously demonstrated that that EC-selective (over)expression of Pfn1 accelerates RCC progression, and conversely, genetic loss of EC-Pfn1 dramatically inhibits tumor angiogenesis impeding tumor initiation and/or progression in RCC, suggesting that Pfn1 could be an actionable therapeutic target in RCC.

Primary Mucinous Ovarian Carcinoma: Insight into a Rare Histology and Impact of Pattern of Infiltration on Oncological Outcomes.

Primary mucinous ovarian carcinomas (pMOCs) are a rare subtype of epithelial ovarian cancer which have a unique biological behaviour. These tumours have been divided into patterns of infiltration, namely expansile and infiltrative types, which in turn have prognostic significance. A hospital-based, retrospective analytical cohort study was conducted at a tertiary cancer center in Northeast India, from September 2019 to September 2023.

NMR Elucidation of Structure-Dynamics-Function Relationship of Engineered CCL2 Chemokine Monomer.

The monocyte migration at the inflammatory site is regulated by monocyte chemoattractant protein-1 (MCP/CCL2), a crucial CC chemokine existing in equilibrium between monomers and dimers under physiological conditions. The present study unveils the relative structure-stability and functional features for engineered murine CCL2-P8A monomer (CCL2-M) in comparison to dimer (CCL2-WT) using a combination of nuclear magnetic resonance (NMR), biophysical and cell-based techniques. We delineate here the NMR assignment and structural characteristics of wild-type and monomeric versions of CCL2 protein.

Green Synthesis of Biomass-Derived Nitrogen-Doped Carbon Dots for Selective Co and Nitric Oxide Sensing and Bioimaging Applications.

Biomass-derived carbon dots (CDs) offer a sustainable alternative for nanomaterial synthesis; however, their photoluminescence properties often remain suboptimal. This study targets a green and cost-effective hydrothermal approach to prepare nitrogen-doped carbon dots (NCDs) using agricultural residues as precursors, with amine-rich waste serving as the nitrogen source. The resulting NCDs exhibited low cytotoxicity, exceptional water solubility, high stability, and excellent biocompatibility.

Hope for OTHERS (Our Tissue Helping Enhance Research & Science): research results from the University of Pittsburgh rapid autopsy program for breast cancer.

Breast cancer affects 1/8 of women throughout their lifetimes, with over 90% of cancer deaths being caused by metastasis. However, metastasis poses unique challenges to research, as complex changes in the microenvironment in different metastatic sites and difficulty obtaining tissue for study hinder the ability to examine in depth the changes that occur during metastasis. Rapid autopsy programs thus fill a unique need in advancing metastasis research.

A rhodamine 6G derivative for turn-on detection of Fe and Cr: Cell imaging studies.

Fluorescent chemosensors that were reported for the recognition of metal cations like Cr and Fe usually resulted in the fluorescence quenching on interaction with the cations. Herein we report a rhodamine based compound (L-Bz) that produces pink coloration and strong fluorescence increment in the occurrence of Cr and Fe in acetonitrile/water (HEPES buffer, pH 7.4, 99.

Retrieval of Surface Soil Moisture at Field Scale Using Sentinel-1 SAR Data.

The presence of vegetation in agricultural fields affects the accuracy of soil moisture retrieval using synthetic aperture radar (SAR) data. As a result, the estimation of soil moisture using the existing Oh model produces high error values. The magnitude of this error primarily depends upon the nature of crops, crop coverage, and the roughness of the field.

Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line.

Heavy metals are pervasive environmental and occupational carcinogens known to induce uncontrolled cell proliferation. They influence a number of cellular processes, including proliferation, metabolism, apoptosis, and carcinogenesis. Among the several underlying mechanisms of carcinogenesis, metal-induced aberrant modulation of DNA methyltransferase (DNMT) activity may play crucial role.

Damage-associated molecular patterns (DAMPs) in vascular diseases.

Research into the role of chronic sterile inflammation (i.e., a prolonged inflammatory state not caused by an infectious agent) in vascular disease progression has continued to grow over the last few decades.

Discovery of newer 1,3,4-Oxadiazole clubbed Isoindoline-1,3-dione derivatives as potential anticancer agents: Design, machine learning, synthesis, molecular docking, ADMET, DFT and MD simulation.

Cancer remains to be the second leading cause of death, since the available drugs and therapies may get failure due to the early-stage drug resistance, metastasis, poor pharmacokinetics, and toxic effects. This gap can be fulfilled by designing potential anticancer agent with the Phthalimide as a prime scaffold. The robust and reliable pharmacophore model was used for the designing of newer Phthalimide derivatives.

Regulating environmental arsenic-mediated gut-brain toxicity using chitosan-conjugated luteolin gold nanoparticles.

Anxiety and depression are two major contributors to global disease burden. Amongst various causal factors, exposure to even low doses of environmental heavy metals, like arsenic, can induce anxiety and depression-like behaviour in mammals. Ingestion of arsenic, primarily through contaminated drinking water, severely disrupts the gut microbes, thereby inducing structural and functional abnormalities in the brain.

Annihilation-limited long-range exciton transport in high-mobility conjugated copolymer films.

A combination of ultrafast, long-range, and low-loss excitation energy transfer from the photoreceptor location to a functionally active site is essential for cost-effective polymeric semiconductors. Delocalized electronic wavefunctions along π-conjugated polymer (CP) backbone can enable efficient intrachain transport, while interchain transport is generally thought slow and lossy due to weak chain-chain interactions. In contrast to the conventional strategy of mitigating structural disorder, amorphous layers of rigid CPs, exemplified by highly planar poly(indacenodithiophene-co-benzothiadiazole) (IDT-BT) donor-accepter copolymer, exhibit trap-free transistor performance and charge-carrier mobilities similar to amorphous silicon.

Imidazo-phenanthroline based ratiometric optical sensing platform for cyanide and fluoride ions.

The severe toxicity and widespread distribution of fluoride (F) and cyanide (CN) ions in various environmental matrices highlight the urgent need for their efficient and reliable detection methods. In this study, we present a fluorogenic imidazo-phenanthroline based probe (L) for selective detection of F and CN in semi-aqueous medium. Probe L exhibits a pronounced ratiometric fluorescence response upon interaction with these anions, driven by hydrogen bonding interaction involving the N-H group of the imidazole moiety.

Single-shot, receptor-free, rapid detection and classification of five respiratory viruses by machine learning integrated SERS sensing platform.

A machine learning integrated SERS sensing platform is developed for a single-shot, receptor-free, rapid detection and classification of five respiratory viruses including Influenza A, Respiratory Syncytial Virus (RSV), Human Rhinoviruses (Rhino), and two variants of SARS-CoV-2 virus such as Omicron and Delta in clinical nasal and/or nasopharyngeal samples (CNS) in viral transport media (VTM). SERS sensor composed of Ag nano-sculptured thin film (nSTF) is fabricated by glancing angle deposition (GLAD) technique and possess a SERS enhancement factor of the order of 10. Various machine learning (ML) algorithms like Random Forest Classifier (RF), Support Vector Machine (SVM), Logistic Regression (LR), k-Nearest Neighbor (KNN), and Multilayer Perceptron (MLP) are trained on SERS spectra dataset of CNS for classification of the viruses.

Oncological Outcomes in Patients with Delayed Cytoreductive Surgery During COVID Times.

ESMO ESGO guidelines recommend standard 3-4 cycles of neoadjuvant chemotherapy (NACT) for advanced epithelial ovarian cancers (EOC); however, the ideal number of cycles is still debatable. Literature regarding survival after 5 or more cycles is conflicting. COVID pandemic saw several oncosurgeries postponed due to healthcare crises.

Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and Bacopa Monnieri for Accelerated Peripheral Nerve Regeneration.

Peripheral nerve injuries (PNIs) often lead to semi or complete loss of motor, sensory and autonomic functions. Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative.

Deciphering the molecular interactions between monocyte chemoattractant protein and its potential inhibitor suramin.

Chemokines, in coordination with glycosaminoglycans (GAGs) and G protein-coupled receptors (GPCRs), play a critical role in regulating inflammatory responses. Among these, monocyte chemoattractant protein-1, also known as CCL2 stands out for its role in coordinating with other immune molecules to direct macrophage migration, infiltration, and recruitment to inflamed tissues, highlighting this pathway as a promising target for therapeutic intervention. In the present study, suramin, a polysulfonated napthylurea compound, having structure similarity with heparin, initially developed therapeutic for treating Human African Trypanosomas [HAT] was analyzed for its repressive action against CCL2 arbitrated macrophage migration.

An easily synthesizable naphthalene-based sensing platform for Al and Zn ions: theoretical insights and live cells imaging.

A new naphthalene-derived Schiff base probe, 1-((2-(diphenylphosphino)ethylimino)methyl)naphthalen-2-ol (HL), has been demonstrated for fluorometric detection of Al and Zn ions. HL was characterized by elemental analysis, FT-IR, NMR, UV-Vis, fluorescence, and ESI-MS analyses. It exhibited high sensitivity and selectivity toward Al and Zn ions in a semi-aqueous medium (CHCN-HO; 4 : 1, v/v), remaining unaffected by other competing metal ions.

Considering Opportunities and Challenges When Implementing the Model Master File Framework - a Meeting Report.

Unlabelled: [Image: see text]

Supplementary Information: The online version contains supplementary material available at 10.1007/s11095-025-03839-x.

Nano-ionic Solid Electrolyte FET-Based Reservoir Computing for Efficient Temporal Data Classification and Forecasting.

Physical dynamic reservoirs are well-suited for edge systems, as they can efficiently process temporal input at a low training cost by utilizing the short-term memory of the device for in-memory computation. However, the short-term memory of two-terminal memristor-based reservoirs limits the duration of the temporal inputs, resulting in more reservoir outputs per sample for classification. Additionally, forecasting requires multiple devices (20-25) for the prediction of a single time step, and long-term forecasting requires the reintroduction of forecasted data as new input, increasing system complexity and costs.

The root-derived syringic acid and shoot-to-root phytohormone signaling pathways play a critical role in preventing apple scab disease.

Apple scab is a serious disease that has a huge economic impact. While some cultivars of apple are scab-resistant, most are not. Growing research has suggested that root-derived metabolites play a vital role in conferring resistance to aboveground pathogens through the long-distance signaling system between shoot and root.