Nanotherapeutics Mediated Intranasal Delivery for Therapeutic Effect on Parkinson's Disease: Balancing Advancements and Challenges.

Managing Parkinson's Disease (PD) presents formidable challenges due to the impermeability of the Blood-Brain Barrier (BBB), which severely restricts effective drug delivery. Traditional treatment modalities often prove inadequate, prompting the exploration of intranasal drug delivery as a novel and promising alternative. This innovative approach provides direct access to the central nervous system while bypassing the Blood-Brain Barrier (BBB).

Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?

The HIV-1 pandemic presents a multifaceted challenge across the globe, standing as the foremost public health crisis today. Global data on HIV-related morbidity and mortality are alarming. Effective HIV management hinges on minimizing transmission through highly active antiretroviral therapy (HAART), which relies on a combination of HAART and has been a cornerstone in HIV management.

A review on biomacromolecular ligand-directed nanoparticles: New era in macrophage targeting.

Traditional drug delivery strategies often have side effects due to uneven drug distribution leading to the subtherapeutic impacts. Ligand-modified nanoparticles offer a revolutionary approach to precise drug delivery. These modified nanoparticles can potentially target macrophages, which is crucial for defense and disease progression efficiently.

Conceptual Overview of Prevalence of Prediabetes.

Prediabetes increases the risk of type 2 diabetes, metabolic syndrome, chronic renal disease, and cardiovascular disease in a person. In current practice, five alternative definitions of prediabetes are utilized, each based on different HbA1c, fasting glucose, and 2-hour glucose cut points. Prediabetes is a common condition that occurs between normal glycemia and diabetes.

Small molecules as cancer targeting ligands: Shifting the paradigm.

Conventional chemotherapeutics exploration is hampered due to their nonspecific distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for chemotherapy becomes a question of concern for many terminally ill cancer patients. However, with evolving times nanotechnology assisted in reducing the haywire distribution and channelizing the movement of drug-enclosing drug delivery systems to cancer cells to a greater extent, yet toxicity issues still could not be obliterated.

Pattern stabilization in swarms of programmable active matter: A probe for turbulence at large length scales.

We propose an algorithm for creating stable, ordered, swarms of active robotic agents arranged in any given pattern. The strategy involves suppressing a class of fluctuations known as "nonaffine" displacements, viz., those involving nonlinear deformations of a reference pattern, while all (or most) affine deformations are allowed.

Exploring the link between crystal defects and nonaffine displacement fluctuations.

We generalize and then use a recently introduced formalism to study thermal fluctuations of atomic displacements in several two- and three-dimensional crystals. We study both close-packed and open crystals with multiatom bases. Atomic displacement fluctuations in a solid, once coarse grained over some neighborhood, may be decomposed into two mutually orthogonal components.

Translationally invariant colloidal crystal templates.

We show that dynamic, feed-back controlled optical traps, whose positions depend on the instantaneous local configuration of particles in a pre-determined way, can stabilise colloidal particles in finite lattices of any given symmetry. Unlike in a static template, the crystal so formed is invariant under uniform translations and retains all possible zero energy modes. We demonstrate this in silico by stabilising the unstable two-dimensional square lattice in a model soft solid with isotropic interactions.