Pheochromocytoma metastasis to the central nervous system: a case report and systematic review.

Background: Pheochromocytoma (PCC) is a rare neuroendocrine tumor, with 10-15% of cases showing malignant behavior defined by metastatic spread, including exceptionally rare central nervous system (CNS) involvement. Brain metastases present unique diagnostic and therapeutic challenges due to their potential to impair neurological function. This study reports a case of malignant PCC (mPCC) with CNS metastases and a systematic review to clarify the clinical patterns, management strategies, and prognostic factors.

Research Note: Impact of different carrot forms on production results and physiochemical features of carcass elements in broiler ducks.

The objective of this study was to evaluate the effect of dietary inclusion of different carrot forms on production results, carcass traits, meat quality, fatty acid (FA) composition, vitamin content, and feed costs in Cherry Valley broiler ducks. A total of 240 one-day-old males (initial body weight of 55.2 g) were allocated to 4 treatments (n = 60; 6 replicates of 10 birds): control (CD; 100 % commercial diet), CFL (CD + 2 % carrot flakes), RAWC (80 % CD + 20 % raw carrot), and CPOW (CD + 2 % carrot powder).

River transport of Hg as a potential contamination pathway for sediments, soils and vegetation: management practices.

River systems, besides shaping their landscapes through the formation of Fluvisols, can also act as pathways for transporting significant pollutants, affecting both the river and its surrounding areas. One such pollutant is mercury (Hg). To assess the impact on sediments and adjacent riverbanks, including Fluvisols and their vegetation, the alluvial plains near Poland's most important river have been studied to understand this process and propose effective management measures.

Sex Differences in Vitamin Metabolism and Their Role in Oxidative Stress Regulation and Cardiometabolic Health.

Vitamins A, D, E, K, B2, B12, and C play a key role in regulating metabolism and oxidative stress, significantly impacting cardiometabolic health. This review uniquely integrates mechanistic and epidemiological data to examine sex-specific differences in the bioavailability, metabolism, and physiological effects of these vitamins. By linking hormonal and genetic factors with oxidative stress modulation, lipid metabolism, and endothelial function, we outline how individualized vitamin intake strategies may help prevent cardiovascular and metabolic disorders.

Degradation Characteristics of Microstructure and Mechanical Properties on the Cross-Section of a Massive Casting Made of G17Mn5 Steel.

This paper presents the changes in microstructure and mechanical properties that occurred across the wall cross-section of a massive slag ladle casting due to service conditions. The slag ladle was made of low-carbon cast steel. Based on the test results, it was shown that the working environment influenced the macro-segregation of C and S on the cross-section of the wall and, consequently, had an effect on the changes in microstructure.

Evaluation of a Method for Determining Material Strength Based on Hardness Measurements: A Case Study of the Ti6Al4V Alloy.

The aim of this study was to evaluate the feasibility of estimating the tensile strength of Ti6Al4V alloy, based on HV measurements. The investigation included samples that were manufactured using both additive technology and conventional methods, under various conditions: as-built, heat-treated, and untested mechanically. Static tensile tests and HV measurements were performed to assess the influence of the manufacturing method, heat treatment, and mechanical loading on material performance.

Oxidative Stress and Neurotoxicity Biomarkers in Fish Toxicology.

Exposure to xenobiotics causes pathophysiological changes in fish, including oxidative stress and neurotoxicity. Here, we describe the biochemical mechanisms underlying oxidative stress (i.e.

Selected Protective Mechanisms of Human Milk Against Intestinal Protozoal Infections in Infants.

Human milk, especially colostrum, is a biologically complex fluid with potent protective properties against gastrointestinal disturbances in infants. Among intestinal protozoa transmitted via the fecal-oral route, this review focuses on and , as the protective role of milk-derived factors against these parasites is the most extensively documented. Its protective effects result from a wide range of bioactive components, including mucins, lactoferrin, human milk oligosaccharides, melatonin, and secretory IgA, which support the integrity of the intestinal barrier, regulate immune responses, and inhibit the adhesion and activity of pathogens.

Increased Expression of Bacterial Cellulose Synthase Genes in Exposed to a Rotating Magnetic Field.

The objective of this study was to investigate the alterations in the expression of () genes in, dependent on the exposure duration and specific parameters of a rotating magnetic field (RMF). cells were subjected to an RMF at frequencies of 5 and 50 Hz for durations ranging from 12 to 72 h. Gene expression was assessed using quantitative polymerase chain reaction (qPCR).

Neural pathways to bariatric success: What explainable AI reveals that conventional fMRI methods may miss.

Aims: Metabolic-bariatric surgery (MBS) remains a cornerstone of obesity treatment, yet 15%-30% of patients fail to achieve its intended benefits. Existing clinical and biochemical markers offer limited value in identifying who will respond favourably to this intervention. We hypothesize that the long-term success of MBS is influenced by individual differences in preoperative brain function.

Changes in carcase composition, gastrointestinal morphometry and leg bone dimensions in different goose genotypes after a four-year reproductive period.

1. The aim of this study was a comparative analysis of three goose genotypes (Rypińska, Suwalska, Kartuska) after a four-year laying period at the National Research Institute of Animal Production, Waterfowl Genetic Resources Station in Dworzyska. It examined carcase composition as well as morphometric parameters of their digestive system and leg bones.

Comparative analysis of the World Health Organization Reporting System for Head and Neck Cytopathology and the Milan System for Reporting Salivary Gland Cytopathology.

Background: A comparative analysis of the International Academy of Cytology-International Agency for Research on Cancer-World Health Organization Reporting System for Head and Neck Cytopathology (WHO) and the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was performed.

Methods: A total of 2218 salivary gland fine-needle aspiration samples collected at the Institut Curie, Paris (1954-2022) were evaluated, with 1356 having histological follow-up. Samples were classified according to the MSRSGC (nondiagnostic [ND], nonneoplastic [NN], atypia of undetermined significance [AUS], benign neoplasm [BN], salivary gland neoplasm of uncertain malignant potential [SUMP], suspicious for malignancy [SM], and malignant [M]) and the WHO system (insufficient/inadequate/nondiagnostic, benign, atypical, neoplasm of uncertain malignant potential [NUMP], suspicious for malignancy [SM], and malignant [M]).

Transgenerational effects of in ovo stimulation with synbiotic and choline on gonadal tissue across three generations.

Epigenetic mechanisms play a pivotal role in hereditary processes, shaping phenotypic outcomes across generations. This study investigates the transgenerational impacts of in ovo injection of bioactive substances on gene expression and DNA methylation in the male gonads using the Green-legged Partridgelike chickens as a model organism. Synbiotic PoultryStar (Biomin; PS) and choline were injected in ovo on the 12th day of egg incubation.

Application of the Milan and IAC-IARC-WHO Systems in diagnosing soft tissue and bone tumors of the salivary glands: The Institut Curie experience.

Background: Soft tissue and bone tumors of the salivary gland were compared using classic 4-tier, Milan System for Reporting Salivary Gland Cytopathology (MSRSGC), and the International Academy of Cytology-International Agency for Research on Cancer-World Health Organization (IAC-IARC-WHO) Reporting System for Soft Tissue Cytopathology.

Methods: The authors retrospectively analyzed 2219 salivary gland fine-needle aspiration (FNA) samples collected at the Institut Curie in Paris between 1954 and 2022. A total of 86 cases (3.

Compressible CoO@MoS Aerogel as an Advanced Functional Electrode for Asymmetric Supercapacitors.

For the development of next-generation portable energy storage devices, compression-tolerant electrodes are essential, but most of the previous reports have focused only on carbon-based materials. Herein, gelatin methacrylate (GelMA) and poly(-isopropylacrylamide) (PNIIPAM) were used as hosts to incorporate the CoO@MoS aerogel (CoO@MoS AG). GelMa-PNIPAM (GP) was transformed into a carbon network as an intrinsically compressible host template with high conductivity.

The use of reduced graphene oxide (rGO) as de-icing agent in engineered cementitious composites (ECC).

In this study, it is aimed to prevent traffic accidents caused by icing by producing an innovative concrete pavement that is both heatable and has high ductility in order to solve the ductility and icing problems encountered in rigid pavements used in highways. For this aim, rGO-ECCs were produced by adding different proportions of Reduced Graphene Oxide (rGO) to Engineered Cementitious Composites (ECC) known for their high ductility properties. The mechanical, electrical and heating properties of rGO-ECCs in different environments were investigated.

Wide-field quantitative micro-elastography of freshly excised human prostate.

Prostate cancer is a significant global health issue. To advance diagnostic and treatment procedures, such as image-guided needle biopsy, optical imaging methods offering high spatial resolution have been proposed. Optical coherence tomography (OCT) allows for detailed visualization of prostate microarchitecture in three dimensions; however, it does not reliably differentiate tumors from surrounding healthy tissue.

Proximate Composition, Physicochemical Properties and Concentration of Selected Minerals in Edible Giblets of Geese.

The purpose of this study was to determine the effect of breed and sex (3 × 2) on the basic chemical composition, concentration of some minerals, and physicochemical properties of edible giblets of farm geese. The study material consisted of edible giblets (livers, gizzards, hearts) obtained from 42 geese from three Polish native breeds (Rypin, Suwałki, Kartuzy) at 220 weeks of age. Edible giblets were obtained during goose evisceration from seven males and seven females of each breed.

The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies.

Alcohol dependency is a complex and chronic condition that negatively impacts multiple organ systems, including the skin. A key pathological factor in this process is oxidative stress, leading to progressive cellular damage, chronic inflammation, and accelerated cutaneous aging. Alcohol metabolism generates reactive oxygen species (ROS), which overwhelm endogenous antioxidant defenses and contribute to a range of skin alterations, including nonspecific changes such as xerosis, erythema, and wrinkle formation, as well as inflammatory and neoplastic skin disorders.

Antibacterial and Antifungal Tannic Acid Coating on Plasma-Activated Titanium Alloy Surface.

Titanium (Ti) alloys, renowned for their exceptional physicochemical properties and high biocompatibility, are widely utilized in orthopedic and dental implants; however, their lack of intrinsic antimicrobial activity significantly increases the risk of implant-associated infections, often leading to severe complications and implant failure. Developing antimicrobial coatings on Ti implants is therefore a promising strategy. In this study, tannic acid (TA) coatings were deposited by immersing Ti alloy surfaces-beforehand activated by low-temperature oxygen plasma-in TA solutions at 2, 5, and 8 wt%.

NGS coverage accurately predicts and () gene amplifications in a real-world non-small cell lung cancer cohort.

Background: Fluorescence hybridization (FISH) is the current standard for detecting gene amplifications, yet its low throughput and practical constraints call for alternative methods. This study evaluates next-generation sequencing (NGS) as a potential tool for accurately predicting gene amplifications.

Methods: We analyzed 66 primary non-small cell lung cancer (NSCLC) samples, tested by both NGS and FISH.

Seven years of follow-up of first-in-human percutaneous epicardial-only left atrial appendage closure using Sierra device.

Background: It is estimated that at least one third of the population will suffer from atrial fibrillation in their lifetime. In order to prevent strokes and thromboembolism, anticoagulation treatment should be administered. In addition, exclusion of the left atrial appendage should be considered in certain cases to prevent fatal ischemic complications.

Pulmonary Complications in Connective Tissue Disease-Associated Interstitial Lung Disease.

Interstitial lung disease (ILD) associated with connective tissue disease (CTD) is a challenging entity burdened with multiple risk factors and undesirable events. ILD can occur at any time and progress regardless of the underlying disease activity. Apart from the established difficulties in choosing an appropriate treatment strategy for both pulmonary and extrapulmonary involvement, such patients require a holistic and multidisciplinary approach.

FeO nanoparticles and IAA auxin affect secondary metabolism over time without altering genetic stability in chrysanthemum.

This research studied the impact of bare iron oxide nanoparticles (FeO NPs), citrate-stabilized iron oxide nanoparticles (FeOCA NPs), and indole-3-acetic acid (IAA) on the genetic stability and metabolic activity of Chrysanthemum × morifolium (Ramat.) Hemsl. plants obtained from synthetic seeds.

Recovery of Natural Pyrazines and Alcohols from Fusel Oils Using an Innovative Extraction Installation.

The production of spirits generates significant amounts of waste in the form of fusel oils-previously treated mainly as an environmental problem. This paper presents an innovative installation designed to recover valuable components from this difficult waste. The key achievement is the effective separation and recovery of pyrazine derivatives-natural aromatic compounds with high utility value in the food, cosmetics and pharmaceutical industries.