Association of Electrocardiographic Patterns After Successfully Resuscitated Out-of-Hospital Cardiac Arrest With Significant Coronary Lesions and Mortality-A Predefined Substudy of the Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation (TOMAHAWK) Trial.

Objectives: The use of electrocardiograms for predicting significant coronary lesions and mortality in patients with successfully resuscitated out-of-hospital cardiac arrest (OHCA) without ST-segment elevation has not been defined yet. The objective of this study was to investigate the association and predictive value of various standardized 12-lead electrocardiogram patterns in patients with successfully resuscitated OHCA and no ST-segment elevations on the presence of significant coronary lesions (diagnostic performance) and 30-day mortality (prognostic performance).

Design: Predefined subanalysis of the Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation (TOMAHAWK) trial.

Nondestructive and robust detection of different kinds of vegetable oils adulterated with used frying oil by multi-optical properties.

Developing a rapid and non-invasive detection tool for frying oil adulteration in pure vegetable oils holds the considerable significance. In this study, a self-developed optical system which combined double integrating spheres (DIS) and laser induced fluorescence (LIF) techniques was applied to obtain the optical properties of adulterated oils, which involved four categories: peanut, corn, rapeseed, and soybean oils, with each category from two distinct brands. The captured multi-optical properties included absorption coefficient (μ), reduced scattering coefficient (μ') and fluorescence intensity (F).

Identification of IGF2BPs-related mRNA signature for predicting the overall survival of lung adenocarcinoma.

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are m⁶A readers that stabilize target mRNAs by recognizing the GG(m⁶A)C sequence. While previous studies have explored the biological mechanisms of IGF2BPs in lung cancer, their prognostic value remains unclear. This study investigated the expression, molecular mechanisms, and prognostic significance of IGF2BPs in lung adenocarcinoma (LUAD) using TCGA and GEO datasets.

Stability Comparison of Implants with Alumina Sandblasting and Acid Etching Surface Treatment: A Retrospective Cohort Study.

This retrospective cohort study aimed to compare and evaluate the 1-year stability of two Korean implant brands, Osstem and Toplan, both treated with alumina- sandblasting and acid- etching (SA) surface modification. This retrospective analysis evaluated patients with American Society of Anesthesiologists grade I or II, >20 years, with alveolar bone volume suitable for implant placement, who received immediate or delayed placement after extraction, and with Osstem ( = 57) or Toplan ( = 87) implants. The insertion torque value (ITV) measured on the day of implant placement and the implant stability quotient (ISQ) measured on the day of implant placement, 1 month post-surgery, and 2-3 months after implantation were analyzed.

A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency.

Background: Delta storage pool disease (δ-SPD) is a rare platelet function disorder (PFD) characterized by a deficiency of dense granules or defective granule secretion, leading to bleeding diathesis. Diagnostics of δ-SPD are difficult and lack standardization, leading to underestimation of its prevalence. Current diagnostic methods are based on granule content assays or lumi-aggregometry, which have limited availability.

Comparison of continuous glucose monitoring with self-monitoring of blood glucose in type 1 diabetes in the changing atmospheric pressures in aviation: a hypobaric flight simulation.

Aim/hypothesis: Pilots with type 1 diabetes are required to perform capillary glucose monitoring regularly during flights. Continuous glucose monitoring (CGM) may be an effective and more practical alternative. This study aimed to assess the accuracy of CGM systems against self-monitoring of blood glucose (SMBG) during a hypobaric flight simulation.

Comprehensive extractables and leachables sensitization analysis and practical application of a risk-based approach to sensitization assessment for parenteral drug products.

The Extractables and Leachables Safety Information Exchange (ELSIE) Consortium added to the sensitization potency analysis of Parris et al. (2023) by including the Product Quality Research Institute (PQRI) extractable and leachable dataset (Johnson et al., 2024; Product Quality Research Institute, 2021).

Assessment of Reperfusion Efficacy of Altelyse Versus Actilyse in Patients with Acute Myocardial Infarction: A Phase 3, Randomized, Double-Blinded, Non-inferiority Clinical Trial.

Background: Primary percutaneous coronary intervention (PPCI) and fibrinolytic or thrombolytic therapy are common treatments for ST-elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention is more effective than thrombolytic therapy, but fibrinolytic therapy is still a preferable option for patients with limited access to healthcare. Alteplase is a tissue plasminogen activator (tPA) used to treat acute myocardial infarction, acute ischemic stroke, and pulmonary embolism.

Electrochemical Method for the Assay of Organic Peroxides Directly in Acetonitrile.

Lipid peroxidation is a major process that determines the quality of various oil samples during their use and storage, in which the primary products are hydroperoxides (HP'). HP' are very stable compounds at ambient conditions and are harmful to human health. Therefore, the evaluation of the degree of oil oxidation is an excellent tool for ensuring food safety.

Ritlecitinib, a JAK3 /TEC inhibitor, modulates the markers of celiac autoimmunity in alopecia areata and vitiligo patients.

Background: Celiac disease (CeD) has shown an association with autoimmune disorders including vitiligo and alopecia areata (AA). Ritlecitinib, a JAK3 and TEC kinase family inhibitor, has been approved for treatment of patients with AA and is in late-stage development for vitiligo. Ritlecitinib inhibits cytotoxic T cells, NK cells, and B cells which play a role in the pathogenesis of CeD.

Investigation of additional suitable positive controls in the human Cell Line Activation Test.

The human Cell Line Activation Test (h-CLAT) is an in vitro skin sensitization assay adopted by the OECD as Test Guideline 442E. In the h-CLAT, 2,4-dinitrochlorobenzene (DNCB) is used as a positive control; however, DNCB is considered a poisonous substance under the Poisonous and Deleterious Substances Control Act in Japan since 2014 because of its high acute toxicity. Strict control, handling, and storage are required when using DNCB, which is a burden to the users.

"Low Carbon Brazilian Beef": How is it perceived by Brazilians?

"Low Carbon Brazilian Beef" (LCBB) represents a Brazilian concept brand that certifies livestock systems adopting specific technical guidelines to minimize methane gas emissions from cattle. Understanding consumers' perceptions of this brand concept can help develop strategies to promote its consumption. The objective of this study was to investigate the perception of Brazilian consumers living in the state of Rio de Janeiro regarding the LCBB through free word association and to evaluate the influence of socio-demographic variables, green consumption values and frequency of beef consumption in associations.

Health and Liver Diagnostic Markers Influencing Glycemia in Subjects with Prediabetes: Preview Study.

Introduction: Glucose homeostasis may be dependent on liver conditions and influence health-related markers and quality of life (QoL) objective measurements. This study aimed to analyze the interactions of glycemia with liver and health status in a prediabetic population.

Subjects And Methods: This study included 2220 overweight/obese prediabetics from the multinational PREVIEW project.

Comprehensive Analysis of Physicochemical Properties and Sensory Attributes of Original-Cut Potato Chips in the Chinese Market.

This study investigates the Chinese market's physicochemical properties and sensory attributes of 14 original-cut potato chip brands. Color characteristics, compositional analysis, sugar content, acrylamide levels, and textural properties were examined alongside sensory evaluations. Significant variations were observed across all the parameters.

The healthfulness of major food brands according to Health Canada's nutrient profile model for proposed restrictions on food marketing to children.

Objective: To examine the proportion of products offered by leading food brands in Canada that are 'unhealthy' according to Health Canada's (HC) nutrient profile model for proposed restrictions on food marketing to children (M2K-NPM).

Design: Nutritional information for products offered by top brands was sourced from the University of Toronto FLIP and Menu-FLIP 2020 databases, respectively. HC's M2K-NPM, which includes thresholds for Na, total sugars and saturated fat, was applied to products.

Development and industrial application of geographical origin identification for Taiwanese oolong tea.

Taiwanese oolong tea is renowned for its excellent quality and enjoys a prestigious reputation both domestically and internationally. In recent years, there has been an issue with imported Taiwanese-style oolong tea being sold as genuine Taiwanese oolong tea, which has adversely affected the brand value of Taiwanese oolong tea. In this study, samples of domestic oolong tea (Taiwanese oolong tea) and Taiwanese-style oolong tea produced abroad (including China, Vietnam, Indonesia, Thailand, etc.

Reciprocating Torsional Fatigue and Mechanical Tests of Thermal-Treated Nickel Titanium Instruments.

Introduction: This study aimed to evaluate the mechanical properties of Reciproc, Reciproc Blue, One RECI, and R-Motion, specifically focusing on their flexibility and buckling resistance and to assess their torsional fatigue behavior under 2 different reciprocation angles (150°/30° or 70°/30°).

Methods: A total of 160 instruments (40 per brand) were tested. Flexion and buckling tests were conducted using a Universal testing machine (DL 200 MF).

Overseas residency rights of Chinese listed firms' controllers: Impacts on R&D and public welfare donations.

By developing an intertemporal decision-making model, this paper investigates the impact of the acquisition of overseas residency by a firm's beneficial owner on the firm's intertemporal decision-making. By incorporating a discount rate in the model, the paper finds that obtaining foreign residency alters the temporal distributional characteristics of the utility of the beneficial owner, weakening its preference for intertemporal investment behaviors such as R&D and donations. We then conduct an empirical analysis using the propensity score matching method for Chinese listed firms.

Investigation of Trace and Macro Element Contents in Commercial Cat Foods.

Background: Nutritional profiles and guidelines are determined by various associations to ensure optimum health of cats and provide pet food manufacturers nutritional recommendations to ensure the well-balanced and nutritionally adequate pet food.

Objectives: It was aimed to determine some trace elements and macro minerals in prescription and non-prescription dry cat foods and compare the contents with the suggested guidelines to evaluate the potential in-compliance.

Methods: A total of 96 dry cat foods were evaluated.

Fatigue failure testing of human hair: Weibull-analysis for constant strain experiments.

Fatigue failure testing of materials is an important aspect of assessing their strength and resilience under long-term, oscillatory stresses and/or strains. This also applies to human hair. For this investigation, we decided to complement existing experience on cyclic tests at various levels of constant stress with those at various constant strains (4-30%).

Fluorescence and color adjustment potentials of paste-type and flowable resin composites in cervical restorations.

Objective: Comparatively assess the fluorescence and color adjustment potentials of paste-type and flowable resin composites performed in cervical restorations.

Materials And Methods: Five paste-type resin composites and 5 highly-filled flowable composites were investigated (n=5 for each). Class V cavities on 50 extracted A2 shade human central incisors were restored.

Quantification of normal bone and osseous metastases in castration-resistant prostate cancer using SPECT/CT with xSPECT Quant: prospective imaging sub-study of a phase 2 clinical trial investigating the combination of pembrolizumab plus radium-223 compared to radium-223 alone.

Objective: The purpose of this study is to demonstrate the consistency and reproducibility of quantitative SPECT/CT by evaluating the maximum SUV (SUV) in normal bone, to provide the reference value of metastatic lesions, and to evaluate the clinical implication of SUV changes of osseous metastasis during treatment.

Material And Methods: This prospective imaging sub-study was performed as part of a phase 2 clinical trial of patients with metastatic castration-resistant prostate cancer (mCRPC) randomized to the combination of pembrolizumab plus radium-223 or to radium-223 alone (NCT03093428). The maximum standardized uptake value (SUV) and mean Hounsfield Unit (HU) of normal bone as well as metastases were measured using a 1.

Statistical analyses plan for "MAGnItude of cigarette substitutioN after initiation oF e-cigarettes and its ImpaCt on biomArkers of exposure and potenTial harm in dual users": MAGNIFICAT trial.

Background: The substitution of combustible cigarettes (CC) with non-combustible nicotine alternatives, such as e-cigarettes (EC), significantly lowers exposure to harmful chemicals. However, many individuals who use ECs continue smoking CCs, becoming dual users and remaining at increased risk of toxin exposure. This study will examine how the reduction in cigarettes smoked per day (CPD) after switching to ECs correlates with changes in biomarkers of exposure (BoE) and potential harm (BoPH) to evaluate the extent of harm in dual users.

Blood Loss in Women of Childbearing Potential Taking Oral Anticoagulants for Venous Thromboembolism (The BLEED Study).

Oral anticoagulants (OAC) may exacerbate menstrual bleeding in women of childbearing age; however, the existing literature on this issue has several limitations.This study investigates abnormal uterine bleeding in women of childbearing age taking OAC-vitamin K antagonists or direct oral anticoagulants-for venous thromboembolism through a retrospective analysis of prospectively collected data. Uterine bleeding was assessed using the Pictorial Blood Assessment Chart (PBAC) and hemoglobin (Hb) values during anticoagulation compared with prior therapy.