The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.

Outcomes of high BMI colorectal cancer patients with natural orifice specimen extraction surgery: a propensity-score matching study.

Background: Natural orifice specimen extraction surgery (NOSES) is widely used for colorectal cancer. However, there is limited study regarding the outcomes of patients with high BMI who undergo NOSES surgery for colorectal cancer.

Methods: This retrospective study included 251 patients (including 205 Non-High BMI and 46 High BMI patients) who underwent NOSES for colorectal cancer between January 2013 and December 2018.

Identification of Key Gene Related to Matrisome in HBV-Associated Liver Cirrhosis via Bioinformatics Analysis.

Hepatitis B virus (HBV)-associated liver cirrhosis, characterized by progressive fibrosis and regenerative nodule formation, remains a critical public health concern due to its high risk of progression to hepatocellular carcinoma (HCC). The matrisome-comprising extracellular matrix (ECM) components such as collagens, laminins, fibronectin, glycoproteins, and proteoglycans-plays a pivotal role in disease pathogenesis. Previous studies have shown that HBV infection modulates ECM composition and activates fibrogenic responses through hepatic stellate cells, contributing to cirrhosis and eventual HCC development.

Short-term effects of remote ischemic conditioning on vascular function in patients with cardiovascular diseases: a systematic review with meta-analysis.

Objective: The purpose of this systematic review with meta-analysis was to compare the short-term (≤1 month) effects of remote ischemic conditioning versus sham remote ischemic conditioning on vascular function in patients with cardiovascular diseases.

Methods: A systematic review was conducted to identify relevant studies through six healthcare science databases up to March 2025. Arterial stiffness and endothelial function were defined as the primary outcome.

[Features of the clinical course of reccurent diseases lymphoepithelial ring of the pharynx in children].

We present results researchchildren with reccurens infections lympho-epithelial ring, revealed features of the clinical manifestations adeno-tonsillar pathology, studied etiology factors of bacterial and viral nature in formation reccurence course diseases in children, noted role virus herpes 6 type in formation pathology lymphoepithelial ring in young children.

Preservation of ALYREF Phase Separation Mitigates Doxorubicin-Induced Cardiomyocyte DNA Damage and Cardiotoxicity.

The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. ALYREF, a nuclear protein that preserves genomic stability through interactions with intranuclear components or as an m⁵C-binding regulator of mRNA maturation and export, has not been previously implicated in DOX-induced cardiotoxicity (DIC). Here, the role and underlying mechanisms of ALYREF in the pathogenesis of DIC are investigated.

[Approaches to medical rehabilitation of patients with post-stroke hemianopsia].

Visual impairment is reported in about a third of stroke patients. It significantly reduces patients' quality of life and leads to maladjustment in everyday life and disability. There are three main areas of medical rehabilitation for patients with visual impairments after a stroke: restoration of visual fields (restorative therapy), modification of behavior to compensate for lost visual function (training of compensatory capabilities), and replacement of a visual defect using devices or external modifications (replacement therapy).

Macular Atrophic versus Subretinal Proliferative Changes in Myopic and Age-Related Macular Degeneration: The 2-Continent Eye Study.

Objective: To assess the prevalences of subfoveal retinal pigment epithelium (RPE) loss versus subfoveal tissue proliferation as causes of vision loss in patients with late-stage age-related macular degeneration (AMD) or myopic macular atrophy.

Design: Population-based studies conducted in Russia, China, and India and histological examination of enucleated human globes.

Participants: The Russian Ural Eye and Medical Study ( = 5899 participants; age: ≥40 years), Ural Very Old Study ( = 1526; age: 85+ years), Beijing Eye Study ( = 3468; age: ≥40 years), and Central India Eye and Medical Study ( = 4711) were conducted in rural and urban regions in Bashkortostan/Russia, Beijing/China, and Nagpur/India, respectively.

Dynamics of the Novel Cardiac Biomarkers sST2, H-FABP, GDF-15 and suPAR in HFrEF Patients Undergoing Heart Failure Therapy, a Pilot Study.

Despite improvements in medical therapy, heart failure with reduced ejection fraction (HFrEF) is a major burden on the healthcare system and remains a leading cause of death with a 5-year mortality rate of more than 60%. Novel therapeutic agents such as angiotensin-receptor-neprilysin-inhibitors (ARNIs) lead to significant improvement in clinical outcomes. Optimal therapy monitoring under these novel drugs is crucial for improving the outcome.

Ammonium Catecholaldehydes as Multifunctional Bioactive Agents: Evaluating Antimicrobial, Antioxidant, and Antiplatelet Activity.

A wide range of water-soluble quaternary ammonium acylhydrazones based on catecholaldehyde were synthesized and characterized using NMR, IR spectroscopy, and elemental analysis. The total antioxidant capacity of the acylhydrazones discussed herein was estimated via coulometric titration with electrogenerated bromine. Pyridinium derivatives - exhibited the highest antioxidant capacity.

[Effect of polymorphic variants of the HTR2A gene on the effectiveness and safety of sertraline in patients with mixed anxiety-depressive disorder].

Objective: To identify pharmacogenetic markers of the effectiveness and safety of sertraline pharmacotherapy at polymorphic loci (-1438G>A, rs6311), (102c>T, rs6313), (1354C/T, rs6314), (rs7997012 G>A) of the gene in patients with mixed anxiety-depressive disorder from the Republic of Bashkortostan.

Material And Methods: The study included 100 patients treated with sertraline. The effectiveness and safety of sertraline therapy in patients were assessed using standardized psychometric scales on the day before the start of therapy and then for 42 days.

Intravitreal panitumumab and retinal pigment epithelium proliferation in laser-induced retinal degeneration in rabbits.

Purpose: This study aims to examine the effect of intravitreally applied epidermal growth factor (EGF) receptor blocker panitumumab on the proliferation of retinal pigment epithelium cells (RPE) in an experimental model of localized retinal degeneration.

Methods: The experimental study included rabbits with age of 2 to 3 months and body weight of 2.5-3 kg and which were randomly distributed into a study group and control group.

The use of alendronate to enhance transcranial transmission of focused ultrasound for successful ablations in brain.

Objective: The aim of this study was to evaluate the efficacy of alendronate therapy in improving bone density distribution in skull bones and corresponding ultrasound permeability in patients who had previously experienced unsuccessful transcranial MR-guided focused ultrasound (MRgFUS) ablation. The ability of alendronate treatment to modify skull bone characteristics and enhance the success rate of repeat MRgFUS procedures was assessed.

Methods: Five patients with initially unsuccessful MRgFUS ablations underwent a 6-12 month regimen of alendronate to improve bone density.

Exploring the Association Between Urinary Incontinence and Depression Based on a Series of Large-Scale National Health Studies in Türkiye.

: Urinary incontinence (UI) and depression are prevalent conditions affecting millions globally and are significantly associated with various demographic, health, and socio-economic factors. This study examines the associations between UI and depression over a 14-year period using nationwide data. : We analyzed cross-sectional data from the Turkish Health Studies Surveys conducted in seven different years between 2008 and 2022, including 125,276 participants aged 15 and older and excluding those with incomplete key health data.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects.

Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, including schizophrenia (SCZ), autism (ASD), bipolar disorder (BD), depression (MDD), PTSD, and ADHD (N = 574,965). Using gene-set burden analysis (GSBA), we tested duplication (DUP) and deletion (DEL) burden across 2,645 functional gene sets defined by the intersections of pathways, cell types, and cortical regions.

Targeting programmed death ligand 1 for anticancer therapy using computational drug repurposing and molecular simulations.

Discovering new drug candidates for complex diseases like cancer is a significant challenge in modern drug discovery. Drug repurposing provides a cost-effective and time-efficient strategy to identify existing drugs for novel therapeutic targets. Here, we exploited an integrated in-silico approach to identify repurposed drugs that could inhibit programmed death-ligand 1 (PD-L1).

Multicenter Single-Blind Randomized Controlled Trial of the Romiplostim Biosimilar.

Background: This was a randomized multicenter single-blinded active-controlled equivalence Phase III study evaluating the efficacy and safety of the biosimilar of romiplostim (GP40141) compared to the reference drug Nplate in patients with persistent or chronic immune thrombocytopenia (ITP).

Methods: The study included 136 adult patients randomized 1:1 to receive either the biosimilar or reference drug for 26 weeks. The primary endpoint was the proportion of patients achieving a platelet response (≥ 50 × 10/L) at Week 11.

Heteropaternal superfecundation in dizygotic twins: a case report and literature review.

Purpose: Superfecundation, the fertilization of two oocytes by different spermatozoa within the same ovulatory cycle, can result in monopaternal or heteropaternal dizygotic twins. While monopaternal superfecundation is more common, heteropaternal superfecundation is rare and typically seen in disputed paternity cases. This study presents a case of heteropaternal superfecundation confirmed through forensic DNA analysis and reviews its occurrence in existing literature.

Angiogenesis and Resistance Mechanisms in Glioblastoma: Targeting Alternative Vascularization Pathways to Overcome Therapy Resistance.

Introduction: Glioblastoma (GBM), the most aggressive form of primary brain tumor in adults, remains a significant clinical challenge due to its high recurrence and poor prognosis. Characterized by rapid growth, invasiveness, and resistance to therapy, GBM relies on a sophisticated vascular network to sustain its progression. Angiogenesis, the process of forming new blood vessels, is central to meeting the metabolic demands of the tumor.

Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.

Inflammatory bowel disease (IBD) is a chronic condition in which endoplasmic reticulum (ER) stress and subsequent apoptosis of intestinal epithelial cells play significant roles. E3 ubiquitin ligases and deubiquitinases are crucial in IBD pathophysiology by modulating protein ubiquitination. This study investigated the regulatory role of a deubiquitinase ubiquitin-specific peptidase 13 (USP13) in a DSS-induced colitis mouse model and explored the underlying mechanism.

Testosterone, sex hormone-binding globulin, and fracture risk in men: evidence from observational and Mendelian randomization analyses.

Unlabelled: Both observational and factorial Mendelian randomization analysis revealed that the combined exposure to higher TT and lower SHBG was associated with decreased risk of fracture. These findings suggest that considering both TT and SHBG-rather than focusing on testosterone alone-may improve fracture risk assessment.

Purpose: Lower total testosterone (TT) levels have been associated with increased fracture risk in aging men, yet the benefits of testosterone supplementation remain uncertain.

Phosphorus-Derived Isatin Hydrazones: Synthesis, Structure, Thromboelastography, Antiplatelet, and Anticoagulation Activity Evaluation.

A series of new isatin hydrazones bearing phosphorus-containing moiety was synthesized through a simple, high-yield and easy work-up reaction of phosphine oxide (Phosenazide) or phosphinate (2-chloroethyl (4-(dimethylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate, CAPAH) hydrazides with aryl-substituted isatins. The P NMR technique showed that, in most cases, out of 12 examples in solution, the ratio of the two spatial isomers varied from 1:1 to 1:3. Quantum chemical calculations confirmed the predominance of form both in the gas phase and in solution.

Oncological and Functional Outcomes of Hemi-Ablation Versus Focal Ablation for Localized Prostate Cancer Using Irreversible Electroporation.

: Irreversible electroporation (IRE) is a novel ablative treatment modality for localized prostate cancer and aims at achieving oncological control while minimizing the related side effects. We present the functional and oncological outcomes of focal IRE ablation versus hemi-ablation from a single-center patient series. : Men with histologically confirmed low-intermediate risk prostate cancer received focal IRE ablation or hemi-ablation.