Angiogenesis and Resistance Mechanisms in Glioblastoma: Targeting Alternative Vascularization Pathways to Overcome Therapy Resistance.

Introduction: Glioblastoma (GBM), the most aggressive form of primary brain tumor in adults, remains a significant clinical challenge due to its high recurrence and poor prognosis. Characterized by rapid growth, invasiveness, and resistance to therapy, GBM relies on a sophisticated vascular network to sustain its progression. Angiogenesis, the process of forming new blood vessels, is central to meeting the metabolic demands of the tumor.

Unilateral biportal endoscopic in spine surgery: a global bibliometric analysis of research trends and influences.

Purpose: Unilateral biportal endoscopic (UBE) technique is increasingly utilized in spine surgery, offering minimally invasive solutions with promising outcomes. This study conducts a comprehensive bibliometric analysis of global research trends and key influences in UBE application.

Methods: A systematic search in the Web of Science Core Collection was performed on June 9, 2024, focusing on English publications related to UBE and spine surgery.

Long Non-coding RNAs as Key Modulators in Hypoxic-Ischemic Brain Injury: Implications for Neuroprotection.

Long non-coding RNAs (lncRNAs) are a complex and diverse group of transcripts, typically longer than 200 nucleotides, which do not encode proteins but play crucial roles in regulating gene expression. They exert their influence through various mechanisms, such as interacting with DNA, mRNA, and proteins, which allows them to modulate a wide array of biological processes. Recent studies have underscored the importance of lncRNAs in the development of the nervous system and the pathogenesis of neurological diseases, particularly in the context of hypoxic-ischemic brain injury.

lncRNAs and circRNAs: Emerging Players in Pediatric Medulloblastoma Pathology.

Medulloblastomas (MBs) are the most common malignant brain tumors in children, marked by aggressive growth, molecular heterogeneity, and a high propensity for cerebrospinal dissemination. Despite advancements in conventional treatments - surgery, chemotherapy, and radiation therapy-substantial challenges persist, including debilitating long-term toxicities and emerging resistance to therapy. This review examines the multifaceted roles of non-coding RNAs (ncRNAs) - particularly long non-- coding RNAs (lncRNAs) and circular RNAs (circRNAs) - in pediatric medulloblastoma pathogenesis, diagnosis, and therapeutic targeting.

Non-coding RNAs-based Therapy and Angiogenesis: A New Era for the Management of Gliomas.

The relentless pursuit of understanding and combating glioblastoma (GBM), one of the most formidable foes in the realm of cancer, requires a deeper exploration of its intricate dynamics. Gliomas, particularly GBM, are known for their lethal nature, and a significant aspect of their pathogenesis lies in their ability to manipulate the blood vessels that sustain them. This complex relationship is governed by a multitude of molecular mechanisms involving a diverse array of cell types within the tumor microenvironment.

New approaches to targeted drug therapy of intracranial tumors.

Intracranial tumors encompass a heterogeneous group of neoplasms, including gliomas, meningiomas, pituitary adenomas, schwannomas, craniopharyngiomas, ependymomas, medulloblastomas, and primary central nervous system lymphomas. These tumors present significant challenges due to their diverse molecular characteristics, critical locations, and the unique obstacles posed by the blood-brain barrier (BBB) and blood-tumor barrier (BTB), which limit the efficacy of systemic therapies. Recent advances in molecular biology and genomics have enabled the identification of specific molecular pathways and targets, paving the way for innovative precision therapies.

Interaction between microRNA and KRAS in Glioblastoma.

Glioblastoma (GBM) characterized byits rapid progression and challenging prognosis, often featuring mutations in the Kirsten rat sarcoma virus (KRAS) gene, which is crucial for numerous cellular signaling mechanisms. Emerging research underscores a significant interaction between KRAS and microRNAs (miRNAs) in these cancers, with miRNAs playing key roles as both regulators and mediators within the KRAS signaling framework. The concept of oncogene-induced senescence (OIS) is explored as a protective mechanism against tumor development, examining how K-RAS signaling is meticulously adjusted to bypass senescence, thereby enhancing cell growth and survival.

Artificial intelligence in surgery: evolution, trends, and future directions.

Artificial intelligence (AI) is significantly transforming surgery by enhancing precision, decision-making, and patient outcomes. This bibliometric analysis examines AI's impact on surgery, highlighting research trends, key contributors, and evolving themes from 1998 to 2024. Utilizing data from the Web of Science Core Collection and analyzed through the Bibliometrix tool, the study reviews publication trends, author impact, institutional contributions, country-specific research activities, and keyword frequency.

The Mechanism of Action of Exosomes Derived from Glioblastoma Cells.

Glioblastoma (GBM) is a highly aggressive and lethal brain tumor characterized by rapid growth, invasive behavior, and resistance to conventional therapies, such as surgery, radiotherapy, and chemotherapy. Despite these interventions, patient survival remains poor due to the tumor's ability to recur and adapt to treatments. The function of GBM-derived exosomes (GBM-exosomes) as essential mediators in tumor growth has drawn attention in recent years.