Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.scib.2025.06.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis.
Phytomedicine
October 2025
Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China. Electronic address:
Background: The study elucidates wogonin's therapeutic mechanisms in osteoarthritis (OA) induced by medial meniscus destabilization (DMM), focusing on macrophage polarization regulation, inflammatory signaling modulation, and cellular crosstalk within OA joints.
Methods: A DMM-induced OA mouse model received intra-articular injection of wogonin for 8 weeks. In vitro analyses utilized LPS-stimulated Raw264.
The LSD1/HDAC dual-target inhibitor for cancer therapy: Challenge and opportunity.
Bioorg Chem
August 2025
Department of Obstetrics and Gynecology, Zhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment Zhengzhou China, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:
In recent years, the epigenetic regulation in tumor development has garnered significant attention. The lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC), key enzymes involved in epigenetic modification, are overexpressed in various cancers and promote tumor cell proliferation and differentiation by modulating histone modifications. Although single-target inhibitors for LSD1 or HDAC exhibit efficacy in preclinical models, their clinical utility is hindered by compensatory signaling pathways and the emergence of drug resistance.
View Article and Find Full Text PDFFemale Mice Lacking LSD1 in Myeloid Cells Are Resistant to Inflammatory Bone Loss.
Cells
July 2025
Division of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.
Osteoclasts, which are derived from myeloid precursors, are essential for physiologic bone remodeling but also mediate pathological bone loss in inflammatory diseases such as periodontitis and rheumatoid arthritis. Lysine-specific demethylase (LSD1/KDM1A) is a histone demethylase that modulates the chromatin landscape via demethylation of H3K4me1/2 and H3K9me1/2, thereby regulating the expression of genes essential for deciding cell fate. We previously demonstrated that myeloid-specific deletion of LSD1 (LSD1LysM-Cre) disrupts osteoclast differentiation, leading to enhanced BV/TV under physiological conditions.
View Article and Find Full Text PDFCurrent Advances and Future Directions for Sensitizing Gastric Cancer to Immune Checkpoint Inhibitors.
Cancer Med
July 2025
Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Immunotherapy combined with chemotherapy has become the standard treatment for HER2-negative gastric cancer (GC), but its clinical benefits remain limited, with a median progression-free survival (mPFS) of 6-8 months and median overall survival (mOS) of 15-18 months. These outcomes are particularly poor in patients with CPS < 1. The marked heterogeneity of GC, along with primary and secondary resistance, presents significant clinical challenges and underscores the urgent need for novel therapeutic strategies.
View Article and Find Full Text PDFLSD1 modulates ovarian reserve establishment by modifying FOXO3 and mitophagy-related genes.
Sci Bull (Beijing)
June 2025
State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China. Electronic address: