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| http://dx.doi.org/10.3324/haematol.2025.287794 | DOI Listing |
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation.
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August 2025
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
The vast majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia are poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly barcoded SIVmac239M, treated with ART for 70 weeks, and necropsied on day 12 after ART discontinuation. Barcode analysis of plasma following ART discontinuation identified 1 to 38 rebounding barcode-defined viral lineages per animal, with 1 to 4 rebounding lineages contributing to first measurable rebound viremia.
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Adaptive Laboratory Evolution (ALE), a well-established framework in microbial evolution research, is widely applied in synthetic biology. By simulating natural selection through controlled serial culturing, ALE promotes the accumulation of beneficial mutations, leading to the emergence of specific adaptive phenotypes and bypassing the complexities inherent in rational genetic engineering. With advancements in next-generation sequencing and molecular biology, the integration of high-throughput omics and molecular tools with ALE has significantly enhanced the mapping of genotype-phenotype relationships and the characterization of mutational landscapes.
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Bahir Dar Institute of Technology, Faculty of Electrical and Computer Engineering, Bahir Dar University, Bahir Dar, Ethiopia.
Burst errors are common in high data rate communication, such as in the Six-Generation (6G) communication system, which degrades its ultra-high reliability requirements. In this study, we have demonstrated how Reed-Solomon codes can be combined with Fifth-Generation (5G) new Radio polar codes to correct burst errors for the 6G system. We have used serial and hybrid concatenating methods.
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