Configuring the Code: Enhancer-Promoter Arrangement and Transcriptional Regulation.

The precise spatial and temporal regulation of gene expression through enhancer-promoter (E-P) interactions represents a fundamental mechanism underlying cellular differentiation and organismal development in multicellular eukaryotes. Despite extensive studies on enhancer-mediated gene regulation, a systematic understanding of how specific E-P configurations affect transcriptional dynamics remains incomplete. Recent advances in live-imaging, single-cell assays, and chromatin conformation capture technologies have enabled unprecedented insights into these dynamic regulatory processes by providing temporal resolution and single-cell specificity that complement traditional population-based approaches.

Clinical validation of liquid biopsy-RECIST (LB-RECIST) in metastatic colorectal cancer (mCRC) patients: findings from the PLATFORM-B study.

Background: Circulating tumor DNA (ctDNA) variations predict tumor response to systemic treatment (so-called molecular response) earlier than radiological assessment. However, a standardized categorization of molecular response is an unmet clinical need. Liquid biopsy-RECIST (LB-RECIST), based on aggregate variant allele frequency (aggVAF; sum of all detected variant allele frequencies in a sample) variations, has been proposed to stratify molecular response.

Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensus.

Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorporating both patient-reported and clinician-reported outcomes.

Sex differences in (poly)phenol intake patterns and cardiovascular risk in Spanish adult population at high risk of cardiovascular disease: Cross-sectional findings.

Background: Men and women tend to follow different dietary patterns, but this is often disregarded when relating diet to health outcomes.

Objective: Our aim was to analyze (poly)phenol intake patterns and their association with cardiovascular risk (CVR) according to sex.

Methods: 6633 participants were included in this cross-sectional study.