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http://dx.doi.org/10.1016/j.jchf.2025.102520 | DOI Listing |
Heart Lung Circ
September 2025
Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; Department of Cardiology, Central Adelaide Local Health Network, Adelaide, SA,
Cardiovascular-kidney-metabolic (CKM) syndrome is a term that is increasingly used to describe interconnected conditions that lead to poor health outcomes, including cardiovascular disease, chronic kidney disease, type 2 diabetes, and obesity. Historically, there have been very few targeted pharmacotherapies available that have changed cardiovascular outcomes for people with CKM syndromes; however, over the past decade, new pharmacologic options have rapidly expanded, with strong evidence for cardiovascular and kidney protective benefits in CKM conditions. Of note, sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists have emerged as key therapeutic options and are now widely guideline-endorsed.
View Article and Find Full Text PDFExp Cell Res
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China. Electronic address:
Background: Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) progression. This study aimed to develop and validate a prognostic model integrating EGC- and CRC-associated gene expression to predict patient survival, recurrence, metastasis, and therapy response.
Methods: Bulk and single-cell RNA sequencing data were analyzed, and a machine learning-based model was constructed using the RSF random forest algorithm.
J Foot Ankle Res
September 2025
La Trobe Rural Health School, La Trobe University, Bendigo, Australia.
Background: Acute Charcot neuroarthropathy (CN) is a rare but serious complication of diabetes that requires timely diagnosis and evidence-based management to prevent long-term disability. In regional or rural settings, delivering evidence-based care is particularly challenging due to systemic and contextual barriers.
Objective: To explore the perceptions of patients and health professionals about assessment, diagnosis and management of acute CN in a regional Victorian health service.
J Prim Care Community Health
September 2025
Department of Family Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Aims: To identify risk factors for hyperglycemia in emergency department visits within 1 year following type 2 diabetes diagnosis.
Methods: In this retrospective cohort study, electronic medical record data from 3333 adult patients newly diagnosed with type 2 diabetes across 57 primary care clinics in West Michigan between April 2021 and January 2023 were analyzed. The primary outcome was hyperglycemia at ED encounters within 12 months of diagnosis.
J Diabetes Investig
September 2025
Department of Rehabilitation, Hiroshima University Hospital, Hiroshima, Japan.
Purpose: Lower limb muscle strength is often reduced in patients with type 2 diabetes and is associated with a lower quality of life and poorer walking ability. Diabetic peripheral neuropathy (DPN) may contribute to muscle weakness, though evidence is inconsistent. No meta-analysis has specifically examined the effect of DPN on lower limb muscle strength.
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