Three-year outcomes of neoadjuvant immunotherapy plus chemotherapy in patients with locally advanced esophageal squamous cell carcinoma: a real-world retrospective study.

Background: The objective of this study was to evaluate the efficacy, safety, as well as the 3-year survival outcomes of neoadjuvant immunotherapy with chemotherapy (NICT) plus surgery in patients with locally advanced esophageal squamous cell carcinoma (ESCC) in real-world settings.

Methods: We performed a retrospective analysis of patients with locally advanced ESCC who underwent surgery after NICT in our hospital between May 2019 and Mar 2022, with a median follow-up of 37.6 months.

Predicting tumor response to TACE plus lenvatinib and PD-1 inhibitors for unresectable HCC: A multicenter observational study.

Objectives: Preoperatively identifying patients with unresectable hepatocellular carcinoma (uHCC) who are likely to achieve an objective response to the treatment regimen of transarterial chemoembolization (TACE) plus lenvatinib and programmed death-1 inhibitors (TLP) remains challenging. We aimed to develop and validate a predictive model for tumor response to TLP treatment in patients with uHCC.

Materials And Methods: Patients with uHCC who received TLP treatment were divided into training (n = 107), internal validation (n = 46), and external validation (n = 52) cohorts.

Induction of CXCL8 by endoplasmic reticulum stress promotes migration and invasion of esophageal squamous cell carcinoma through activation of SMAD2/3.

Endoplasmic reticulum stress (ERS) is a protective stress response aimed at mitigating its own abnormal proteins, which is closely associated with tumors. However, the molecular mechanism of ERS in the pathogenesis of esophageal squamous cell carcinoma (ESCC) remains unclear. In the present study, RNA sequencing was carried out in the ESCC ERS cell model , and differentially expressed genes were screened, among which CXCL8 with exhibited differential expression which was studied.

Targeted Reprogramming of Tumor Cells by Digoxin-Loaded Immunogenic Nanoparticles Enhances Immunity Against Disseminated Tumor Cells.

To potentiate the in situ vaccine effect of radiotherapy (RT), an "inflamed-cell-as-vaccine" strategy is proposed. Specifically, a biomimetic, tumor-targeting nanoparticle (rVAR2-M-NP) carrying a Digoxin-Ovalbumin (Dig-Ova) complex is engineered as its core payload. This nanoparticle-induced gentle immunogenic cell death (ICD) stress promotes self-inflammation in tumor cells without causing direct cytotoxicity.

A multifunctional oxidative stress amplifier for synergistic disruption of redox homeostasis and enhanced cancer therapy.

Emerging nanomedicines that target and disrupt redox homeostasis present a compelling yet technically demanding strategy for cancer therapy. Herein, a multifunctional oxidative stress amplifier, denoted as C-COF@MnO-BSA-FA/Ce6 (CMBFC), was engineered to disrupt redox homeostasis through synergistic mechanisms precisely. The nanoplatform was constructed with a core of N-doped carbon nanospheres derived from covalent organic frameworks (C-COF), which was then coated by an in situ mineralized MnO layer.

Ultrasound-responsive diagnostic and therapeutic micro-/nanoplatforms for biomedical applications and clinical translation.

Ultrasound is a widely utilized diagnostic and therapeutic tool in biomedicine due to its non-invasiveness, biocompatibility, cost-effectiveness, and high tissue penetration depth. With the continuous development of materials science and nanomedicine, ultrasound-based diagnosis and treatment have achieved significant advancements. By combining ultrasound as a trigger with responsive biomaterials, platforms with diagnostic and therapeutic performance for specific diseases could be established, offering a promising approach for the development of precise medicine.

Therapeutic Effect of a Composite Acellular Matrix/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis/Bladder Pain Syndrome in a Rat Model.

This study investigated the therapeutic effects of a composite small intestinal submucosa decellularized extracellular matrix/hyaluronic acid (HA)-incorporated thermosensitive hydrogel (HA-Gel) on interstitial cystitis (IC) in rats. The HA-Gel was fabricated using rabbit small intestinal submucosa-derived extracellular matrix as a thermosensitive scaffold combined with HA, and an IC rat model was established using the UPK3A65-84 peptide. Rats were divided into five groups: IC group, IC + HA group, IC + Gel group, IC + HA-Gel group, and a non-modeled control group.

Diagnosis and treatment of a patient with severe hepatitis and rash caused by toripalimab: A case report.

Rationale: Immune-related adverse events have been frequently reported using immune checkpoint inhibitors. However, these reports are commonly observed in single-organ toxicity. Thus, the compound, multiple, multisite, and multi-organ toxicities are seldom recognized and lack treatment experience, finally leading to severe challenges in the clinical treatment of such patients.

Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.

[This corrects the article DOI: 10.3389/fonc.2025.

A patient with severe fever with thrombocytopenia syndrome complicated with intracranial and pulmonary aspergillosis.

Some patients with severe fever with thrombocytopenia syndrome (SFTS) develop complications including viral encephalitis and fungal infections, with a mortality rate reaching 44.7 %. In this case, the patient was admitted on Day 5 of illness, with symptoms of apathy and a delayed response.

Diagnostic performance of dual-layer spectral CT Radiomics and deep learning for differentiating osteoblastic bone metastases from bone islands.

Background: This study aimed to compare the diagnostic performance of radiomic features derived from dual-layer spectral detector computed tomography (DLSCT) and a deep learning (DL) model applied to conventional CT images in the differentiation of osteoblastic bone metastases (OBM) from bone islands (BI).

Methods: This retrospective study included patients with osteogenic lesions who underwent DLSCT examinations between March 2023 and September 2023. We extracted first-order radiomic features (e.

Biomedical informatics analysis has revealed a novel hub gene of the HBx in the pathogenesis and progression of DLBCL.

Hepatitis B virus X protein (HBx) is implicated in the pathogenesis of diffuse large B cell lymphoma (DLBCL). In this study, HBx-stably overexpressing DLBCL cell lines and mouse xenograft models were established to investigate HBx-driven transcriptional changes and functional effects. HBx enhanced cell proliferation, migration, and invasion and altered cell cycle progression.

Tracking the infection dynamics of in based on GFP labelling.

Introduction: root rot, caused by , has caused severe damage to the industry. Due to the unclear pathogenic mechanisms of on , the effective implementation of control measures has been greatly restricted.

Methods: An efficient protoplast preparation and genetic transformation system was established for FO-1, enabling real-time tracking of fungal colonization in .

Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts.

Locusts are characterized by a large genome size, polyphenism and an X0 sex determination system. Here we generated chromosome-level genomes for both desert and migratory locusts, as well as a comprehensive chromatin map for the latter. We found that genome enlargement is associated with an increased number of enhancers in expanded intronic regions.

Astragalin inhibits hepatitis B virus through functional reconstitution of CD8 T cells and a direct effect on HBV control.

Persistent HBV infection promotes hepatic lipid accumulation, a feature linked to immune dysfunction. We found cytotoxic T lymphocytes (CD8 T cells) from chronic HBV infection (CHB) patients exhibited elevated lipid peroxidation in response to hepatic lipids accumulation. And lipid peroxidation drives CD8 T cell dysfunction.

Records of human activities in sediments from the old Yellow River estuary, China: Concentrations, sources, and ecological risks of organochlorine pesticides.

Organochlorine pesticides (OCPs) are important indicators for assessing the intensity of human activities, while estuarine sediments are widely used to reconstruct the historical deposition of pollutants. In this study, a sediment core was collected from the old Yellow River estuary in the Yellow River Delta, China, to analyze the historical deposition of OCPs in detail. The results indicate that the sediment record extends back to 1941, with an average sedimentation rate of 1.

HDAC2 mediates the activation of macrophage in sepsis induced lung injury via regulating the acetylation of SOX2 and the transcription of STAMP2.

Background: Sepsis, characterized by a severe systemic inflammatory response leading to organ failure, often results in acute respiratory dysfunction in approximately half of affected individuals. Understanding the molecular mechanisms underlying pulmonary impairment in sepsis is critical for advancing clinical interventions. This study aimed to investigate the role and mechanism of histone deacetylase 2 (HDAC2) in the progression of septic lung injury (SLI).

Ergodicity Breaking and Ageing in a Vibrational Motor.

The ergodicity and ageing phenomena in a vibrational motor system driven by a periodic external force are investigated. Within the tailored parameter regime, the amplitude and frequency demonstrate contrasting effects on ergodicity. An increase of amplitude induces a transition from non-ergodic to ergodic behavior, whereas a higher driving frequency leads to a transition from ergodic to non-ergodic dynamics.

CRISPR/Cas-Mediated Optimization of Soybean Shoot Architecture for Enhanced Yield.

Plant architecture is a crucial agronomic trait significantly impacting soybean () yield. Traditional breeding has made some progress in optimizing soybean architecture, but it is limited in precision and efficiency. The Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein (CRISPR/Cas) system, a revolutionary gene-editing technology, provides unprecedented opportunities for plant genetic improvement.

Regulatory Mechanism of the GmMYB14 Transcription Factor on Auxin-Related Proteins in Soybean.

In a previous study, overexpressing () transgenic soybean plants displayed a semi-dwarfism and compact phenotype, which was regulated by the brassinosteroid (BR) pathway. However, the phenotype of plants could be partly rescued after spraying them with exogenous BR. This indicates that other hormones, in addition to BR, also play a role in regulating the architecture of plants.

Recent Progress in Flexible Wearable Sensors Utilizing Conductive Hydrogels for Sports Applications: Characteristics, Mechanisms, and Modification Strategies.

Conductive hydrogels demonstrate substantial potential for flexible wearable sensors in motion monitoring, owing to their unique physicochemical properties; however, current implementations still confront persistent challenges in long-term stability, sensitivity, response speed, and detection limits under complex dynamic conditions, which material innovations are urgently required to resolve. Consequently, this paper comprehensively reviews the recent advancements in conductive hydrogel-based flexible wearable sensors for sports applications. The paper examines the conductivity, self-adhesion, self-repair, and biocompatibility of conductive hydrogels, along with detailed analyses of their working principles in resistance, capacitance, piezoelectric, and battery-based sensing mechanisms.

Development and Validation of a Clinlabomics-Based Nomogram for Predicting the Prognosis of Small Cell Lung Cancer in China: A Multicenter, Retrospective Cohort Study.

Background And Objective: Small cell lung cancer has a high incidence and mortality rate, frequently metastasizes, and is associated with a poor prognosis. However, traditional prognostic models based on stage alone cannot meet clinical needs. This study aims to establish a clinlabomics-based, highly accessible prognostic model for small cell lung cancer.

Differentiating pilot distress and eustress via multimodal physiology: towards enhanced human-system integration in intelligent cockpits.

Ensuring safety in next-generation intelligent cockpits demands accurate assessment of pilot states, particularly distinguishing between eustress and distress. Traditional stress monitoring lacks this nuance and struggles across varying flight tasks. This study proposes a multimodal neuro-cardiac framework combining functional near-infrared spectroscopy (fNIRS) and electrocardiography (ECG) to differentiate eustress and distress across tasks.

Molecularly imprinted polymer-based system for simultaneous fluorescence quantification of malachite green and crystal violet.

CdTe QD-doped MIP-based TLC combined with a miniaturized fluorimeter system (namely the system) was developed to simultaneously detect malachite green (4-[(4-(dimethylamino)phenyl)(phenyl)methyl]-N,N-dimethylbenzenaminium chloride, MG) and crystal violet (4-(Bis{4-(dimethylamino)phenyl}methylidene)-N,N-dimethylcyclohexa-2,5-dien-1-iminium chloride, CV). The system integrated CdTe quantum dots-based molecularly imprinted polymers nanoparticles (CdTe-MIP/SiO NPs) with thin layer chromatography (TLC) plates. Firstly, CdTe-MIP/SiO NPs were synthesized by forming an imprinted layer on silica nanoparticle surfaces through a simple one-pot reaction.