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The mucosal zipper endoscopic resection (MZER) technique was developed as a novel approach for treating esophageal submucosal tumors (SMTs). This study aims to introduce the MZER technique and evaluate its feasibility.This retrospective study included 24 patients who underwent MZER between January 2022 and January 2024. Clinical data and treatment outcomes were collected and analyzed.Among these patients, the median distance from the incisor teeth to the SMTs was 25 cm (range: 16-38 cm), the median tumor length was 3.0 cm (range: 2.2-7.0 cm) and the median tumor width was 2.2 cm (range: 1.8-4.0 cm). All esophageal SMTs were successfully resected, achieving an en bloc resection rate of 100%. Intra-procedural perforation occurred in 10 patients (41.7%). The median operation time was 50 minutes (range: 30-180 minutes), and the median duration of hospitalization was 3 days (range: 2-6 days). No delayed bleeding or perforation occurred.MZER seems to provide an optional treatment for proximal or larger esophageal SMTs. The efficacy and safety profiles need further validation through multicenter studies with larger cohorts, given the current limitations of sample size and single-center design.
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http://dx.doi.org/10.1055/a-2605-4708 | DOI Listing |
Dig Dis Sci
September 2025
Zhongshan Hospital, Endoscopy Center and Endoscopy Research Institute, Fudan University, Shanghai, China.
Background And Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.
View Article and Find Full Text PDFObjectives: The usefulness of endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (NETs) is well established. However, factors influencing resection time remain unclear. This study aimed to identify these factors during ESD for rectal NETs.
View Article and Find Full Text PDFCureus
August 2025
Medicine and Pediatrics, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Leiomyomas are the most common benign mesenchymal tumors of the esophagus, and they account for nearly two-thirds of benign esophageal neoplasms. The leiomyomas of the esophagus present with numerous nonspecific symptoms and signs, including dysphagia, shortness of breath, anorexia, weight loss, chronic cough, and bowel obstruction. The patient in this case report presented with moderate to severe right upper quadrant pain and mild dysphagia, which initially prompted evaluation for hepatobiliary pathology.
View Article and Find Full Text PDFJ Cancer Res Ther
September 2025
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
Background: Map-like redness (MLR) is a high-risk membrane factor for early gastric cancer (EGC) after the successful eradication of Helicobacter pylori (Hp). This study aimed to analyze the clinical, endoscopic, and pathological characteristics of EGC with surrounding MLR after successful Hp eradication and evaluate the effect of endoscopic submucosal dissection (ESD) resection.
Methods: This retrospective study comprised 23 patients with EGC and surrounding MLR after Hp eradication (MLR group) and 135 patients with EGC without a surrounding MLR (non-MLR; NMLR group).
Sci Prog
September 2025
Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Colonic intussusception after endoscopic submucosal dissection (ESD) is an uncommon, yet clinically significant complication. Therapeutic approaches for postoperative intussusception encompass conservative management, endoscopic reduction, and surgical intervention. We present a case involving a woman in her early 40s who experienced acute abdominal pain and fever shortly after ESD for a large ascending colonic adenoma.
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