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We report a case of cytomegalovirus retinitis in a hematopoietic stem cell transplant recipient during valganciclovir pre-emptive therapy followed by maribavir. Analysis of UL97 mutation revealed a C480F substitution associated with high maribavir resistance and low ganciclovir resistance.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972909 | PMC |
http://dx.doi.org/10.3947/ic.2024.0131 | DOI Listing |
Ocul Immunol Inflamm
September 2025
Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Purpose: To report a rare case of bilateral necrotising retinitis caused by a potentially novel human adenovirus D (HAdV-D) in a post-bone marrow transplant patient and to highlight the diagnostic challenges and therapeutic role of intravenous cidofovir, alongside a review of previously reported cases of human adenovirus (HAdV) retinitis.
Methods: Retrospective case report.
Results: A 60-year-old man with a history of acute myeloid leukaemia, in remission post-bone marrow transplant, presented with bilateral hypertensive granulomatous panuveitis and necrotising retinitis.
J Vitreoretin Dis
August 2025
Olive-View Medical Center, University of California Los Angeles, Los Angeles, CA USA.
To report an unusual case of uveitis in a patient with AIDS with low CD4 count. A single case was evaluated. A 28-year-old man with AIDS, central nervous system lymphoma, and cytomegalovirus (CMV) viremia developed subacute vitritis in the left eye.
View Article and Find Full Text PDFViruses
August 2025
Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Pyroptosis is a proinflammatory programmed cell death (PCD) that protects the host against invading viruses. We previously reported that pyroptosis plays a prominent role in the pathogenesis of murine cytomegalovirus (MCMV) retinal necrosis using mice with MAIDS as a mouse model for AIDS-related human cytomegalovirus (HCMV) retinal necrosis. Because MCMV and HCMV exhibit species specificity, we sought to determine if pyroptosis induction extends to different cell types of murine or human origin.
View Article and Find Full Text PDFWorld J Stem Cells
July 2025
Department of Ophthalmology, Sultan Qaboos University, Muscat 123, Oman.
Cytomegalovirus (CMV) retinitis is a significant yet infrequent complication in pediatric hematopoietic stem cell transplant recipients, occurring in approximately 4% of cases. Its presentation typically coincides with immune reconstitution, between 6 weeks to 6 months post-transplant, emphasizing the need for timely detection. Symptoms often develop insidiously, underscoring the role of fundus examinations during episodes of CMV viremia.
View Article and Find Full Text PDFJ Pharm Policy Pract
July 2025
Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.
Background: Cytomegalovirus retinitis (CMVR) is an opportunistic infection frequently seen in people living with HIV (PLHIV) and can cause blindness. Intravenous (IV) ganciclovir is a typical CMVR treatment in Thailand, but oral valganciclovir is a more convenient alternative. However, its cost-effectiveness and budget impact remain unclear.
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