Evaluation and Management of Uveitis in a Patient With AIDS With Low CD4 Count and Prior CMV Retinitis.

To report an unusual case of uveitis in a patient with AIDS with low CD4 count. A single case was evaluated. A 28-year-old man with AIDS, central nervous system lymphoma, and cytomegalovirus (CMV) viremia developed subacute vitritis in the left eye.

Vitrectomy in eyes with diabetic retinopathy and light perception vision: A comprehensive outcome analysis.

PurposeTo evaluate the outcome of PPV in PDR patients with a Light Perception (LP) visual acuity at the time of signing up for surgery.MethodsThis retrospective study reviewed patient records from Harbor-UCLA and Olive View Medical Centers between March 2018 and March 2022. 32 patients (32 eyes) with LP visual acuity prior to surgery were included.

Accessory secondary plaque in brachytherapy for uveal melanoma.

Purpose: We describe the technique, indications and outcomes of an accessory secondary brachytherapy plaque for the treatment of uveal melanoma to provide supplemental tumor coverage for the primary brachytherapy plaque.

Methods: Retrospective case series was performed to identify brachytherapy plaque cases for the treatment of primary uveal melanoma where an accessory secondary plaque was created to improve treatment coverage of the uveal melanoma, and positioned at the time of removal of the primary brachytherapy plaque. Baseline tumor, patient characteristics, and clinical outcomes including tumor control, visual acuity, treatment complications, metastases and death treatment were obtained.

Swept-Source Anterior Segment Optical Coherence Tomography of a Vascularized Syphilitic Iris Lesion.

Purpose: To describe the appearance and resolution of a vascularized iris nodule in a case of ocular syphilis with swept-source anterior segment optical coherence tomography (SS AS-OCT) imaging.

Methods: Case report.

Results: A 73-year-old male with a history of ocular syphilis presented with anterior uveitis of the left eye characterized by mutton fat keratic precipitates, anterior chamber cells, hypopyon mixed with hemorrhage, and a vascularized iris nodule.

Novel EDTA-chitosan/alginate porous composite beads for the removal of Pb(ii) and methylene blue from aqueous solutions.

Wastewater containing heavy metals and organic dye pollutants discharged into receiving waters poses a serious environmental concern. Herein, a novel EDTA-chitosan/alginate porous composite bead adsorbent (EC-AB) was reported for the simultaneous removal of lead (Pb(ii)) and methyl blue (MB) complexes from wastewater. Characterization results showed that EC-AB contained plenty of oxygen/nitrogen functional groups.

Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection.

Purpose: To describe a case of acute multifocal retinitis (AMR) and retinal vasculitis associated with Rickettsia typhi.

Methods: Case report.

Results: A 37-year-old previously healthy female presented with acute bilateral panuveitis that was preceded by a febrile illness with pneumonitis and transaminitis.

Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency.

Purpose: This prospective cohort study examined the use of optical coherence tomography angiography (OCTA) to detect in vivo retinal and choroidal variations associated with placental insufficiency, manifesting as fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP).

Methods: Pregnant women were imaged with OCTA from gestational week 16 and every 4 weeks until week 36. Pregnancy outcomes were categorized into three groups: uncomplicated, complicated by late FGR, or complicated by HDP after 32 weeks.

Multifocal Vitelliform Paravascular Retinopathy (MVPR): A New Disorder in the Vitelliform Spectrum.

Purpose: To describe a new retinal phenotype characterized by bilateral, multifocal, subretinal vitelliform lesions along the vascular arcades that we refer to as multifocal vitelliform paravascular retinopathy (MVPR).

Design: Observational case series.

Methods: Multimodal retinal imaging including color fundus photography, fundus autofluorescence and cross sectional and en-face optical coherence tomography was performed to evaluate and characterize the lesions of MVPR.

Deep learning-based algorithm for the detection of idiopathic full thickness macular holes in spectral domain optical coherence tomography.

Background: Automated identification of spectral domain optical coherence tomography (SD-OCT) features can improve retina clinic workflow efficiency as they are able to detect pathologic findings. The purpose of this study was to test a deep learning (DL)-based algorithm for the identification of Idiopathic Full Thickness Macular Hole (IFTMH) features and stages of severity in SD-OCT B-scans.

Methods: In this cross-sectional study, subjects solely diagnosed with either IFTMH or Posterior Vitreous Detachment (PVD) were identified excluding secondary causes of macular holes, any concurrent maculopathies, or incomplete records.

Visual Acuity in Patients Requiring Intravitreal Injections: Short-Term and Long-Term Effects of Delay in Care.

To assess the short-term and long-term effects of a delay in care on visual acuity (VA) in patients requiring intravitreal injections. This retrospective cohort study comprised patients with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), or retinal vein occlusion (RVO) receiving intravitreal injections. The visual and anatomic outcomes at the next completed visit and at the 1-year follow-up were studied.

Hyperoxia Induced Hypomyelination.

We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then removed to room air until P11. Corpus callosal sections were probed myelin immunofluorescence, tested for myelin basic protein concentration by Western blot, and both glial fibrillary acidic protein levels and apoptosis quantified.

Performance of a Machine-Learning Computational Image Analysis Algorithm in Retinal Fluid Quantification for Patients With Diabetic Macular Edema and Retinal Vein Occlusions.

Background And Objective: The objective is to validate an automated artificial intelligence model in detecting and quantifying fluid in diabetic macular edema (DME) and retinal vein occlusion (RVO) optical coherence tomography images.

Patients And Methods: DME ( = 100) and RVO ( = 100) images of adult patients were reviewed. The performance of machine-learning (ML) computational image analysis algorithm was evaluated against consensus manual grading.

Organic Supramolecular Zippers with Ultralong Organic Phosphorescence by a Dexter Energy Transfer Mechanism.

Ultralong organic phosphorescence (UOP) materials glow persistently in the dark, which offers new exciting possibilities in the fields of anti-counterfeiting, photoelectric devices and biological imaging. However, the development of single-component UOP materials remains a great challenge. Herein, we develop a single component organic supramolecular zipper system with a lifetime up to 0.

The Utilization of Phone Communication with Patient Companions During a Pandemic.

Involvement of companions is a critical aspect of patient-centered care. This retrospective cross-sectional study examined patients who were asked, by utilizing electronic medical record (EMR) preset questions (SmartPhrase template), if they wanted another individual called during the assessment and plan portion of an ophthalmology visit. Of 518 patients, 14.

The Effect of Delay in Care among Patients Requiring Intravitreal Injections.

Purpose: To examine the effect of delay in care on visual acuity (VA) in patients requiring intravitreal injections (IVIs).

Design: Retrospective cohort study.

Participants: Patients 18 years of age or older with diabetic macular edema (DME), proliferative diabetic retinopathy (PDR), or both; neovascular age-related macular degeneration (nAMD); or retinal vein occlusion (RVO) scheduled to see a retina specialist during the mandated lockdown period (March 14 - May 4, 2020 [the coronavirus disease 2019 period]) and who had received an IVI in the 12 weeks prior.

Characterization of Kiosk Usage for Ophthalmic Outpatient Visits.

Background And Objectives: This study aims to characterize check-in kiosk usage within a multidisciplinary ophthalmic clinic.

Patients And Methods: Chart review of patients aged 18 or older seen at Cole Eye Institute, Cleveland Clinic, from August 1, 2019, to October 31, 2019. Primary endpoint was percentage of patients who used a check-in kiosk.

Prevention of Macular Edema in Patients With Diabetic Retinopathy Undergoing Cataract Surgery: The PROMISE Trial.

Background And Objective: To determine the safety and efficacy of intravitreal aflibercept injection (IAI) in patients with diabetic retinopathy (DR) in the prevention of macular edema (ME) following cataract surgery.

Patients And Methods: This phase 2, prospective, interventional, single-masked, randomized trial at a single academic center included 30 patients who were 18 years of age or older with nonproliferative DR and undergoing cataract surgery with phacoemulsification. Patients received 2 mg intravitreal aflibercept (0.