Pillar-like Macrocycle Reversibly Self-Assembled from a Molecular Thermally Activated Delayed Fluorescence Emitter Based on B ← N Dative Bonds with Intriguing Fluorescence.

Incorporating boron atoms into organic macrocycles imparts unique chemical, electronic, and optical properties. The concept of making use of dative boron-nitrogen (B ← N) bonds for the construction of macrocycles has been proposed, but very few examples have been prepared with functional structures, much less pillar-like and other prismatic macrocycles, and their various functionalities have not been fully exploited. Here, we introduce a "functional molecular wall" synthetic protocol based on the self-assembly characteristics of B ← N dative bonds to construct highly symmetrical macrocycles, forming a quasi-pentagonal-shaped macrocycle (named [5]pyBN-) with a pillar-like structure.

SEE-phAST: Spatially encapsulated emulsions for phenotypic antibiotic susceptibility testing via sequential digital RAA-CRISPR.

The escalating threat of antimicrobial resistance is exacerbated by delayed diagnostics and improper antibiotics use, underscoring an urgent demand for rapid, versatile AST tools to support evidence-based prescribing. In this study, we present an innovative, generalizable phenotypic AST approach by quantifying bacterial gDNA copy number variations (CNVs) following 0.5-h-brief culturing with antibiotic exposure, termed spatially encapsulated emulsions (SEE)-phAST.

Surgery, radiotherapy and endocrine therapy for oligometastatic prostate cancer efficacy: a systematic review and network meta-analysis.

In recent years, the treatment approach for metastatic prostate cancer has evolved, with early combination therapies increasingly being favored over androgen-deprivation therapy (ADT) alone. Despite the availability of various treatments, their relative effectiveness and safety trade-offs remain uncertain. Randomized controlled trials have explored a range of treatments for oligometastatic prostate cancer, but clear conclusions regarding their prognostic benefits and patient-centered outcomes have not been established.

Multispecies view of the effectiveness of the giant panda conservation programme.

Giant panda (Ailuropoda melanoleuca) conservation programs have attracted significant funding and helped increase panda numbers. However, their effectiveness in achieving wider conservation goals is often doubted. This study evaluates the impact of giant panda reserves on the habitat suitability of 12 endangered species within 5 km of roads and assesses changes in human disturbances.

Phylogenetically and metabolically diverse active carbon-fixing microbes reside in mangrove sediments.

Background: Mangroves are hotspots of carbon sequestration in transitional zones between marine and terrestrial ecosystems. Microbially driven dark carbon fixation (DCF) is prominent in sediments, yet our understanding of the DCF process across this continuum remains limited. In this study, we explored DCF activities and associated chemoautotrophs along the sediment depth of different mangrove sites in Fujian Province, China, using radiocarbon labeling and molecular techniques.

Research on the impact of family doctor contract services on the willingness of residents' first choice of medical institutions for treatment-empirical analysis based on PSM.

Objective: The survey explored the mechanism between family doctor contract services and the willingness of residents' first choice of medical institutions for treatment in Shandong Province.

Methods: Stratified random sampling was used to do the survey. Logistic regression model was used to analyze the influencing factors of residents' willingness to first choice of medical institutions for treatment.

The investigation into the physicochemical properties of fermented soybean meal and its effects as a substitute for soybean meal on the growth performance and intestinal development of broiler chickens.

This experiment aims to investigate the physicochemical properties of fermented soybean meal (FSBM) and its effects on the growth and development of broilers when used as a substitute for soybean meal (SBM). The process optimization of FSBM was based on indicators such as particle size, moisture content, temperature, and the amounts of protease and microbial agents added. The physicochemical indicators of the FSBM meal were measured accordingly.

Global thermal tolerance compilation for freshwater invertebrates and fish.

Scientists have investigated the thermal tolerance of organisms for centuries, yet the field has not lost relevance as the environmental threats of thermal pollution and global change sharpen the need to understand the thermal vulnerability of organisms in landscapes increasingly subjected to multiple stressors. Freshwater fish and invertebrates are greatly underrepresented in recent large-scale compilations of thermal tolerance, despite the importance of freshwaters as a crucial resource and as havens for biodiversity. Therefore we compiled ThermoFresh, a thermal tolerance database for these organisms that includes literature from 1900 until the present, sourced from five languages to counteract geographic bias.

Siloxane-Tethered Halogenated Thiophene Additives Enable Excellent Fibrillar Morphology and Air Processing for High-Performing Polymer Solar Cells.

For organic solar cells (OSCs), morphological optimization and high-performance air-processing of the photoactive layer are important concerns. Herein, three siloxane-tethered halogenated thiophene additives Cl-Th-SiO, Br-Th-SiO, and I-Th-SiO, with chlorine, bromine, and iodine substitutions on the thiophene, are designed and synthesized, respectively. With the three additives, fibrillar active layer networks based on polymer donor D18 and nonfullerene acceptor L8-BO can be achieved.

Rapid self-assembled electroactive biohybrid cathode-driven electron transfer for enhanced uranium bioremediation.

Efficient and eco-friendly purification of uranium-bearing wastewater is essential for the safety of the water ecosystem and sustainable development of the nuclear energy industry. Although bioelectrochemical systems show great prospect for uranium bioremediation, the uranium removal efficiency is often limited by the ineffective quality of biofilm formation and unsatisfactory electron transfer. Here we propose a rapid self-assembled biofilm formation strategy to construct a sulfate-reducing bacteria-carbon cloth biohybrid cathode (CF-PQ7) modified with cotton-derived carbon fibers for the simultaneous removal of uranium and sulfate.

Efficacy analysis of minimally invasive treatment for scapular coracoid fractures assisted by TiRobot ForcePro Superior.

Background: Accurate spatial positioning is the key to the precise implantation of coracoid screws. This study aimed to explore the efficacy and current issues of TiRobot ForcePro Superior (TFS) in the treatment of scapular coracoid fractures by comparing it with the freehand screw implantation technique.

Methods: A retrospective analysis was conducted on the medical records of 29 patients with scapular coracoid fractures who underwent surgical treatment at Foshan Hospital of Traditional Chinese Medicine from 2019 to 2024.

Chemical engineering of γδ T cells with cancer cell-targeting antibodies for enhanced tumor immunotherapy.

Gamma delta (γδ) T cells hold great promise in adoptive cell therapy, but suffer from low tumor-targeting efficiency. Herein, we report the development of antibody-γδ T cell conjugates for enhanced tumor therapy. By evaluating different biomolecules residing on the cell surface, sialic acids-the terminal sugars of various cell-surface glycans-are identified as the optimum site for anchoring antibodies onto γδ T cells via metabolic glycan labeling with unnatural sugars containing a bioorthogonal functional group.

Association between weight-adjusted waist index and severe periodontitis using NHANES 2009-2014.

The Weight-adjusted Waist Index (WWI) is a novel anthropometric indicator for assessing obesity. Given the well-established association between obesity and periodontitis, this cross-sectional clinical study aimed to investigate the relationship between WWI and severe periodontitis while evaluating its potential as a simple predictive marker for periodontitis. The study analyzed periodontal examination data and WWI measurements from participants in the 2009-2014 National Health and Nutrition Examination Survey (NHANES), employing weighted logistic regression, smoothed curve fitting, and subgroup analyses.

From assessment to action: experience from a quality improvement initiative integrating indicator evaluation and adverse event analysis in a clinical laboratory.

Objectives: ISO 15189:2022 recommends the use of quality indicators (QIs) to monitor laboratory performance and focuses on risk management and continual improvement. This study aims to compare hospital laboratory data with national and international quality specifications and to share experiences in quality improvement and adverse event management.

Methods: We evaluated 15 QIs from 2023 by comparing their percentages and sigma levels with those of national benchmarks to identify performance gaps.

Factors influencing HPV vaccination willingness among male college students in Jinan according to the health belief model.

Human papillomavirus (HPV) infection is a significant global public health threat. HPV vaccination in males is crucial for reducing the risk of related cancers and partner infection. On the basis of the health belief model (HBM), this study delves into the factors influencing the willingness to receive HPV vaccination among male college students in Jinan.

Pauling's Rules Guided Design of High-Entropy Sulfide Solid-State Electrolyte with High Ionic Conductivity and Stability.

All-solid-state lithium batteries (ASSLBs) represent a promising next-generation energy storage technology. While sulfide-based solid-state electrolytes (SSEs) offer high ionic conductivity, their practical application is hindered by inherent instability issues. To further enhance the performance, Pauling's rules are considered.

SMARCA4-deficient undifferentiated uterine sarcoma: A case report and literature review.

Rationale: SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) is a rare, sporadic malignant tumor of mesenchymal origin of the uterus, which has highly aggressive and poor prognosis. In this case, we described a malignant tumor formed in the uterus occurring in a SMARCA4 deletion type and discussed its clinical characteristics, differential diagnosis, treatment and related literature analysis.

Patient Concerns: A 61-year-old patient underwent diagnostic scraping at a local hospital for irregular vaginal bleeding for 2 months.

The biomechanical changes of facet joint violation after transforaminal lumbar interbody fusion combined with decompression surgery: a finite element study.

Introduction: Facet joint violation (FJV) is a common complication of intervertebral fusion surgery, altering the load-bearing capability of the facet joints and ultimately contributing to segmental instability. Furthermore, adjacent segment degeneration is one of the potential long-term complications following lumbar spinal intervertebral fusion. For patients with a history of lumbar intervertebral fusion who developed symptomatic spinal stenosis at adjacent segments, adjacent segment decompression surgery is a clinically viable option.

Neutrophil extracellular traps in cardiovascular disease: a bibliometric analysis (2005-2024).

Cardiovascular disease (CVD) has consistently posed a significant challenge in the medical field. Currently, they remain a leading cause of premature mortality. In recent years, the growing recognition of neutrophil extracellular traps (NETs) has revealed their significant involvement in the pathogenesis of CVD.

The distribution of polycyclic aromatic hydrocarbons pollution and the characteristics of microbial diversity in the soil of coal mining areas.

The distribution of polycyclic aromatic hydrocarbons (PAHs) in soil and their impact on soil bacterial communities have garnered significant attention. In this study, we selected the representative Huainan Panji coal mining area as our research site to analyze the diversity of bacterial communities in four distinct zones within the mining area, as well as the relationship between environmental factors and PAHs contamination. A total of 16 PAHs were found to be enriched in the soil, with notably higher concentrations in the coal gangue hill area compared to other regions.

Design of functionalized tips driven by molecule-plasmon coupling.

The sensitivity of plasmon-enhanced spectroscopy (PES) fundamentally arises from the near-field enhancements within plasmonic nanocavities. To further advance PES, we utilized a molecule with exciton modes that are sensitive to the excitation wavelength to functionalize the metal tip. Our findings reveal that exciton modes play a dominant role in shaping near-field patterns.

Role of Activating Transcription Factor 3 in Hyperosmotic Stress-Induced Human Corneal Epithelial Cell Damage.

Purpose: Dry eye disease with ocular surface inflammation leads to corneal epithelial cell damage. This study aims to investigate the role of activating transcription factor 3 (ATF3) in hyperosmotic stress (HS)-induced damage in human corneal epithelial (HCE) cells and to identify new targets for dry eye disease treatment.

Methods: HCE cells were treated with isotonic or hypertonic (312 and 500 mOsM) culture media for 24 hours and added by 94 mM of NaCl to achieve hyperosmotic conditions.