Integrative cognitive neuropsychological program emphasizing brain response to enhance inhibitory control among substance abusers at the alternative rehabilitation communities in Eastern Thailand.

Introduction: Inhibitory control (IC) deficit among substance abusers is a potential consequence of detrimental drug use and can also serve as a risk factor for drug-seeking behaviors, compromising substance abuse treatment and leading to drug relapse. This study examined the efficacy of an integrative cognitive neuropsychological program emphasizing brain response to enhance inhibitory control (ICNIC intervention program) among substance abusers.

Methods: A total of 30 substance abusers were recruited and randomly assigned to either an ICNIC training group and a non-training control group.

Synergistic effects of fatty acids and phenolic compounds on enhancing resistant starch formation in rice starch.

Starch-lipid complexes are classified as resistant starch (RS) type 5 and their formation can be enhanced through the synergistic action of fatty acids and phenolic compounds. This study investigated the effects of stearic acid, lauric acid, gallic acid, and quercetin on V-amylose complex formation, physicochemical properties, crystallinity, and digestibility of rice starch. The addition of these compounds transformed starch crystallinity from A-type to mixed A- and V-type forms, with relative crystallinity increasing dramatically from 11.

How Well Do ChatGPT and Claude Perform in Study Selection for Systematic Review in Obstetrics.

The use of generative AI in systematic review workflows has gained attention for enhancing study selection efficiency. However, evidence on its screening performance remains inconclusive, and direct comparisons between different generative AI models are still limited. The objective of this study is to evaluate the performance of ChatGPT-4o and Claude 3.

Choosing the optimal nonstatin lipid lowering therapies for statin-intolerant patients: A systematic review and network meta-analysis.

Background: Statin intolerance presents a considerable challenge in managing patients at risk for cardiovascular diseases, as it limits patients' access to standard lipid-lowering therapies.

Objective: This study aims to compare the efficacy and safety of various nonstatin lipid-lowering therapies in patients who are intolerant to statins.

Methods: We searched PubMed, Embase, CENTRAL, and EBSCO open dissertations through September 2023 for randomized controlled trials in statin-intolerant patients comparing nonstatin lipid-lowering agents.

Two-stage biorefinery strategy using Rhodopseudomonas harwoodiae KKU-NM3/1-2 for biohydrogen production and dairy farm effluent valorization.

To address the dual challenges of sustainable energy production and agro-industrial waste management, this study presents a novel two-stage biorefinery strategy for the valorization of dairy farm effluent (DFE) using Rhodopseudomonas harwoodiae KKU-NM3/1-2. In Stage 1, an active hydrogen-producing culture was developed using low-cost carbon sources; vinegar was identified as the most cost-effective substrate, yielding 559 mL H/L at 87 % purity and a 7.4-fold cost advantage.

Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin.

: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which have never been synthesized with folate before. : Poloxamer 188 and poloxamer 184 were synthesized with folate by esterification. The in vitro skin penetration enhancement of irinotecan- and alpha-mangostin-loaded folate-conjugated polymeric micelles was evaluated.

Edible Insect Production in Thailand: Sustainable Supply Chain Management.

This study aims to foster a guideline for sustainable supply chain management for edible insect production through a comprehensive review and critical analysis of the current situation, focusing especially on Thailand's perspective. It addresses the traditional culture and modern practice of insect consumption and how these factors affect current production for commercial purposes. The advantages of nutritional values and farming with edible insects over traditional livestock farming are highlighted.

Beneficial Effects of Water-Based Exercise Alone and in Combination with Cognitive Training on Cardiovascular Fitness and Arterial Stiffness in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.

Mild cognitive impairment (MCI) is the transitional stage between normal cognition and dementia and is associated with arterial stiffness, which may lead to cardiovascular disease. A water-based exercise (W) presents a low-impact activity for the joints and increases resistance compared to exercises performed in the air, which benefits older adults. However, little evidence has been found regarding the effect of W on promoting cognitive and physical performance in older individuals with MCI.

Calcified Pulmonary Artery Conduit With Distal Embolism: Challenges in Adult Congenital Heart Disease Post-Rastelli.

Background: The Rastelli procedure is a standard surgical repair for congenital heart disease (CHD). Improved long-term survival has revealed rare complications previously unrecognized.

Case Summary: We report a unique case of a patient with a history of Rastelli repair who presented with left-sided heart failure.

The risk of thyroid diseases in lichen sclerosus patients: a systematic review and meta-analysis.

Background/objective: Lichen sclerosus (LS) is a chronic inflammatory skin disease affecting both genital and extra-genital areas and is found predominantly in female patients. The relationship between LS and thyroid diseases remains unclear, with conflicting evidence reported in the literature. This systematic review and meta-analysis aimed to investigate the association between LS and thyroid diseases rigorously.

Green Smart Packaging Film Based on Kappa-Carrageenan/Poly(Vinyl Alcohol) Enriched with Mexican Petunia Anthocyanins for Visual Detection of Food Freshness.

This research presents a novel approach for the development of environmentally friendly and pH-sensitive films composed of kappa-carrageenan and poly-(vinyl alcohol), designed to facilitate real-time monitoring of food freshness. Sol-gel cross-linked films, enriched with natural anthocyanins extracted from Mexican petunia flowers, were prepared using an aqueous solution casting method. The formation of siloxane cross-linking and the successful incorporation of anthocyanins were confirmed by ATR-FTIR spectroscopy.

Role of Generative Artificial Intelligence in Assisting Systematic Review Process in Health Research: A Systematic Review.

Objectives: Artificial intelligence (AI) is widely used in healthcare for various purposes, with generative AI (GAI) increasingly being applied to systematic review (SR) processes. We aimed to summarize the evidence on the performance metrics of GAI in the SR process.

Methods: PubMed, EMBASE, Scopus, and ProQuest Dissertations & Theses Global were searched from their inception up to March 2025.

Closing the Diagnostic Gap in Medical Mycology: The LODDY Test for Identification of Lodderomyces elongisporus.

Lodderomyces elongisporus is an emerging, cryptic opportunistic yeast increasingly linked to fungemia, especially in immunocompromised patients and those with indwelling devices. Frequently misidentified as Candida parapsilosis due to phenotypic overlap, it escapes timely diagnosis, delaying effective therapy. Despite accounting for < 2% of candidemia cases, true prevalence is likely underestimated.

Structural and functional insights into a novel aldehyde deformylating oxygenase with enhanced efficiency for biofuel applications.

Aldehyde deformylating oxygenase (ADO) plays a crucial role in hydrocarbon biosynthesis by converting C fatty aldehydes into C alkanes, key components of biofuels. However, ADO's low catalytic efficiency and thermostability hinder its industrial application. In this study, we identified a novel ADO from Pseudomonas plecoglossicida (PsADO) using the Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST).

Turnover prevalence and the relationship between transition shock and turnover intention among new nurses: A meta-analysis.

Background: Higher turnover rates of new nurses is a global problem. New nurses are the workforce that retains and prevents the nursing shortage. Many new nurses often experience transition shock during their first year of practice, which correlates with a greater intention to leave the profession.

Deciphering supramolecular and polymer-like behavior in metallogels: real-time insights into temperature-modulated gelation and rapid self-assembly dynamics.

Bis(pyridyl) urea-based gelators, namely L2 and its isomeric mixture (L1 + L2), are known to self-assemble into 1D architectures capable of inducing supramolecular gelation. Coordination with metal ions such as Ag(I), Cu(II), and Fe(III) introduces structural reinforcement, enabling the formation of distinct 3D networks governed by metal-specific coordination geometries. Here, we present a comprehensive investigation into the temperature-responsive behavior (20-60 °C) of L2 and L1 + L2, both in the absence and presence of Ag(I), Dy(III), Fe(III), Cu(II), and Ho(III), using real-time small-angle neutron scattering (SANS).

Effect of Family Nursing Intervention on Suffering Parents of Children with Cancer: A Quasi-Experimental Study.

Background: Childhood cancers often lead to significant distress for parents. This study aimed to evaluate the effects of a Family Nursing Intervention (FNI) on the suffering of parents of children with cancer.

Materials And Methods: This study employed a quasi-experimental design with a sample of 42 parents of children with cancer.

fruit extract attenuates hyperglycemia in type 2 diabetic rats through modulation of oxidative stress and inflammation.

The global incidence of type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, is on the rise, with persistent hyperglycemia contributing to vascular complications. The present study aimed to assess the preventive effects of fruit extract (SSE) on pancreatic β cell dysfunction and associated metabolic disturbances in a diabetic rat model. Male Wistar rats were rendered diabetic through a high-fat diet combined with a low dose of streptozotocin and subsequently divided into four groups: Normal control, diabetic control, diabetic treated with SSE (400 mg/kg) and diabetic treated with glibenclamide (5 mg/kg), a sulfonylurea insulin secretagogue used as a positive control.

Network meta-analysis of immunomodulatory therapies for Behçet's disease-associated uveitis: comparative evaluation of safety and efficacy profiles.

Purpose: To systematically evaluate and compare the efficacy and safety profiles of various immunomodulatory therapies for Behçet's Disease-associated uveitis (BDU) through network meta-analysis, providing evidence-based guidance for clinical practice.

Methods: We conducted a comprehensive systematic review following PRISMA guidelines. Electronic databases (PubMed, Cochrane CENTRAL, Scopus, Google Scholar) were searched for studies published between 2000 and 2025.

Complete genome sequence of the halophilic archaeon Haloferax volcanii PC0224, isolated from a solar saltern in Thailand.

Objectives: Haloferax volcanii is an extreme halophile belonging to the Haloferacaceae family that thrives in hypersaline environments. This study presents the complete genome sequence of the H. volcanii strain PC0224 isolated from a Thai solar saltern.

In Vitro Investigation of the Cytotoxic and Antioxidant Activities of and Extracts With Potential Applications in Breast Cancer Therapy.

and are commonly used to nourish women's blood and treat reproductive system diseases, according to Thai Traditional Medicine (TTM) scriptures. This study explores the biological activities of these herbs as documented in TTMs. Both water and ethanol extracts of the three herbs were examined for their antioxidant activities using DPPH, FRAP, and NO assays.

Green Synthesis of Primary Aniline-Based Indolylmethanes via One-Pot Aza-Friedel-Crafts Reaction Catalyzed by Brønsted Acidic Ionic Liquid in Aqueous Media.

A green, convenient, and metal-free methodology for synthesizing primary aniline-based indolylmethanes has been developed through a sequential one-pot, three-component aza-Friedel-Crafts reaction. This approach employs a wide range of commercially available aldehydes, primary anilines, and indoles, catalyzed by a Brønsted acidic ionic liquid in an aqueous medium. A variety of desirable products were obtained in high yields (up to 98%).

Complex interaction of δ-globin variant HbA-Famagusta combined with β-globin variant Hb Monroe in with the HBB:c.-92C>G mutation: hematological characteristics and molecular diagnostic insights.

Background: Hemoglobin (Hb) variants can cause clinical conditions like thalassemia. Understanding their molecular phenotypes and clinical profiles is essential for accurate diagnosis and genetic counseling.

Research Design And Methods: Blood samples from a 67-year-old Thai female and four relatives were analyzed using HPLC and capillary electrophoresis.

Optimization of levan biosynthesis from using batch and continuous stirred-tank bioreactors: A response surface methodology approach.

Levan, a promising fructan polysaccharide for biopharmaceuticals, has limited large-scale production studies. This research optimized and scaled up levan biosynthesis from in continuous stirred-tank bioreactors based on response surface methodology (RSM). Batch cultures optimized for 30 % (w/v) sucrose, pH 5.

Influence of Various Cooking Methods on Selenium Concentrations in Commonly Consumed Seafood Species in Thailand.

Selenium (Se) is an important trace element in our body; however, food composition data remain limited due to analytical challenges and interferences. Seafood, abundant in Thailand, is recognized as a rich source of Se. This study aimed to expand knowledge on Se content in seafood prepared using traditional Thai cooking methods.