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Article Abstract
Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component system into distinct phases with varying compositions and structures. The latest study has found that protein aggregates formed through phase separation can effectively realize short-distance transport of vesicles. PcloC responds to calcium through C2A domain-mediated calcium sensing, thereby extracting synaptic vesicles from the reserve pool where synaptic proteins aggregate into the surface of the active zone protein condensate. Therefore, PcloC-mediated phase separation may provide a new perspective to understanding short-distance directional transport within cells.
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