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Background: The projection indicates that compound drought and hot events (CDHEs) will intensify, posing risks to cardiovascular health by potentially increasing stroke incidents. However, epidemiological evidence on this topic remains scarce. This study investigates the association between exposure to CDHEs and the risk of daily stroke admissions, specifically examining the effects on various stroke categories such as Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), Ischemic Stroke (IS), Transient Ischemic Attack (TIA), and other types of stroke.
Methods: Data on daily stroke admissions from 2010 to 2015 were obtained from the Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance (URBMI) claims databases in Guangzhou, China. Hot events were identified as days when the daily mean temperature exceeded the 75th percentile during the warm season (May to October) over the study period. The Standardized Precipitation Evapotranspiration Index (SPEI) was utilized to identify drought conditions, with thresholds set at -1 and -1.5 for low-severity and high-severity drought events, respectively. Through a generalized additive model (GAM), we analyzed the cumulative effects of CDHE exposure on daily stroke admissions and calculated the Attributable Fraction (AF) related to CDHEs.
Results: The analysis included 179,963 stroke admission records. We observed a significant increase in stroke admission risks due to exposure to hot events coupled with high-severity drought conditions (RR = 1.18, 95%CI: 1.01-1.38), with IS being the most affected category (RR = 1.20, 95%CI: 1.03-1.40). The AF of total stroke admission attributed to hot events in conjunction with high-severity drought conditions was 24.40% (95%CI: 1.86%-50.20%).
Conclusion: The combination of hot events with high-severity drought conditions is likely linked to an increased risk of stroke and IS admissions, which providing new insights into the impact of temperature and climate-related hazards on cardiovascular health.
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http://dx.doi.org/10.1265/ehpm.24-00168 | DOI Listing |
Cureus
August 2025
Vascular Surgery, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Background Fasting during the month of Ramadan is practiced by over a billion Muslims worldwide. This religious observance, which involves complete abstention from food and fluids during daylight hours, may contribute to dehydration and increase the risk of venous thromboembolism (VTE), particularly in hot climates. Despite this theoretical concern, limited clinical evidence exists on the actual incidence and risk of VTE associated with prolonged fasting.
View Article and Find Full Text PDFEnviron Microbiol Rep
October 2025
Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Barcelona, Spain.
Marine heatwaves are intensifying due to global warming and increasingly drive mass mortality events in shallow benthic ecosystems. Marine invertebrates host diverse microbial communities that contribute to their health and resilience, yet microbiome responses under thermal stress remain poorly characterised across most taxa. Here, we characterise the microbiome composition in colonies of the common Mediterranean bryozoan Myriapora truncata at two depths (13 and 17 m) following the extreme 2022 marine heatwave.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou 311400, China.
As global climate change exacerbates extreme heat events, the interplay between heat stress and blast disease resistance in rice remains poorly understood. In this study, through integrated transcriptome profiling and systematic phenotyping of mutants in several thermosensory pathways, we identified HsfA1 as a positive regulator of heat priming-enhanced blast resistance in rice. Systematic analysis of microRNA (miRNA) dynamics, bioinformatics prediction, and RNA pull-down experiments revealed that , a temperature-responsive miRNA, directly suppresses the expression of by targeting the second exon of messenger RNA (mRNA).
View Article and Find Full Text PDFBioact Mater
December 2025
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic differentiation, and mineralization. Biomaterial can regulate inflammatory responses through relevant immune cells in the local immune microenvironment of the implant-bone interface which is a hot topic in the field of regenerative medicine. Currently, Mg regulates immune cells in the bone microenvironment to promote osteogenesis and angiogenesis mainly focuses on macrophages,but there is relatively little research on T cells.
View Article and Find Full Text PDFEur J Appl Physiol
September 2025
Laboratório de Biomecânica, Centro de Desportos, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Purpose: The environmental conditions in open water swimming (OWS) can impair thermoregulation. Here we explored and discussed four interrelated topics concerning the disruption of thermal homeostasis, in parallel with the underlying physiological mechanisms, during OWS competitions in hot climates: (i) potential health risks; (ii) possible impacts on performance; (iii) technical feasibility of core temperature (Tc) measurement; and (iv) cooling strategies applicable to this context.
Methods: An integrative review was conducted.