Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Previous studies have demonstrated associations between fatty acids and neurological disorders. However, no studies have examined the relationship between serum fatty acid levels and serum neurofilament light chain (NfL), a biomarker of neurological disorders.
Objectives: This study aimed to comprehensively investigate the intricate relationship between 30 serum fatty acids and serum NfL levels in a nationally representative sample of United States adults, using data from the 2013-2014 National Health and Nutrition Examination Survey.
Methods: Using a cross-sectional analysis, multivariable linear regression models were used to explore the associations between 30 serum fatty acids and serum NfL levels. This analysis involved adjustment for potential confounding variables, including age, sex, race, body mass index (BMI), smoking status, hyperlipidemia, and diabetes, to clarify the association between serum fatty acids and serum NfL levels.
Results: The analysis revealed that certain fatty acids exhibited distinct associations with serum NfL levels. Notably, docosanoic acid (22:0) and tricosanoic acid (C23:0) were found to be inversely associated with serum NfL levels (β = -0.280, 95% confidence interval [CI]: -0.525, -0.035; β = -0.292, 95% CI: -0.511, -0.072). Conversely, palmitoleic acid (16:1n-7) demonstrated a positive association with serum NfL levels (β = 0.125, 95% CI: 0.027, 0.222). Notably, these associations remained significant even after adjustment for potential confounders.
Conclusions: Individuals with high relative concentrations of certain SFA exhibited decreased serum NfL, whereas those with high relative concentrations of certain monounsaturated fatty acids showed increased serum NfL. These findings contribute to a deeper understanding of the potential impact of serum fatty acids on NfL levels, shedding light on novel avenues for further investigation and potential interventions in the context of neurological health.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tjnut.2024.07.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The association between weight-adjusted-waist index and serum neurofilament light chain: Results from NHANES 2013 to 2014.
Medicine (Baltimore)
August 2025
Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Neurofilament light chain (NfL) is an important biomarker for neuronal damage, widely used in the study of neurodegenerative diseases. The weight-adjusted-waist index (WWI), as a measure of abdominal obesity, is closely related to metabolic diseases. However, the association between WWI and NfL has not been systematically investigated.
View Article and Find Full Text PDFSerum neurofilament light chain as a prognostic biomarker of glial fibrillary acidic protein autoimmunity.
J Neuroimmunol
August 2025
Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.
This study investigated whether serum neurofilament light chain (NFL) levels could predict the prognosis of patients with Glial Fibrillary Acidic Protein Autoimmunity (GFAP-A). The study included 54 patients diagnosed with GFAP-A at Gifu University Graduate School of Medicine between June 2019 and October 2023. Patients with other neurological diseases or antineuronal antibodies were excluded.
View Article and Find Full Text PDFSerum neurofilament light chain levels are associated with cognitive decline in a consecutive cohort of patients with Alzheimer's disease.
J Neurol Sci
August 2025
Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK2100 Copenhagen, Denmark. Electronic address:
Background: Alzheimer's disease (AD) is characterized by cognitive decline, but the individual progression rates vary. One type of blood-based biomarker that has been widely investigated is neurofilament light chain (NfL), as it reflects measures neuronal damage.
Aim: The aim of the current study was to investigate whether NfL could determine the rate of progression in patients with AD.
Neurofilament light chain in Alzheimer's disease.
Clin Chim Acta
August 2025
Faculty of Pharmacy, AIMST University, Bedong, Kedah 08100, Malaysia. Electronic address:
Neurofilament light chain (NfL) is a sensitive marker of neuroaxonal injury with growing clinical relevance in Alzheimer's disease (AD). Across cohorts, blood and CSF NfL concentrations are higher in AD than controls, with reported 1.7-1.
View Article and Find Full Text PDFSerum biomarkers of delirium in critical illness: a systematic review of mechanistic and diagnostic evidence.
Intensive Care Med Exp
September 2025
Neurosciences Intensive Care Unit, John Radcliffe Hospital, Oxford, UK.
Delirium is a frequent and serious complication of critical illness, yet its pathophysiological mechanisms remain incompletely understood. Serum biomarkers offer a potential avenue for improved diagnosis, risk stratification, and mechanistic insight. This systematic review synthesises evidence from 28 studies evaluating 54 serum biomarkers in relation to delirium among critically ill adult patients.
View Article and Find Full Text PDF