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http://dx.doi.org/10.1007/s00540-024-03356-y | DOI Listing |
Endosc Int Open
August 2025
Gastro Unit, Division of Endoscopy, Copenhagen University Hospital Herlev, Herlev, Denmark.
Background And Study Aims: Remimazolam is a new ultra-short-acting benzodiazepine with a favorable safety-profile when used for sedation in endoscopy. The aim of this project was to investigate efficacy of remimazolam with fentanyl compared with midazolam with fentanyl for sedation in colonoscopy among fecal immunochemical test (FIT)-positive screening participants.
Patients And Methods: The study was a prospective, single-blinded, randomized controlled trial.
J Clin Med
August 2025
Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Republic of Korea.
Total intravenous anesthesia (TIVA) typically combines propofol and remifentanil. Remifentanil exerts minimal influence on motor evoked potential (MEP), whereas propofol partially reduces MEP amplitude. Remimazolam, a novel agent, is a component of TIVA.
View Article and Find Full Text PDFDrug Des Devel Ther
August 2025
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China.
Background: Laparoscopic partial hepatectomy, characterized by significant surgical trauma, profound stress responses, prolonged duration, and high anesthetic requirements, may lead to delayed recovery or emergence agitation. Whether remimazolam and propofol combined with flumazenil reversal can accelerate the recovery and enhance hemodynamic stability remains controversial.
Methods: Fifty patients aged 18-70 years with American Society of Anesthesiologists (ASA) class I-III and Child-Pugh classification A or B undergoing elective laparoscopic partial hepatectomy were enrolled.
Drug Des Devel Ther
August 2025
Department of Anesthesiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Purpose: This study aimed to compare the effects of remimazolam and propofol on hemodynamics in elderly hypertensive patients undergoing gastroenteroscopy.
Methods: In this multicenter, single-blind, randomized clinical trial, 220 hypertensive patients (65-75 years) scheduled for gastroenteroscopy were randomly assigned to receive either remimazolam (group R, n=110; 0.3 mg/kg induction followed by 0.
Drug Des Devel Ther
July 2025
Department of Anesthesiology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, People's Republic of China.
Purpose: To compare the effects of remimazolam and dexmedetomidine on the hemodynamics in elderly patients undergoing orthopedic surgery under spinal anesthesia.
Methods: This study evaluated 126 patients aged ≥ 60 years undergoing lower-extremity orthopedic surgery under spinal anesthesia, randomizing them into remimazolam and dexmedetomidine groups. The primary outcome was the incidence of hemodynamic fluctuations, such as hypotension and bradycardia.