Hypoglycemic effect of -fermented mulberry pomace extract and in .

Food Funct

Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control (Huazhong Agricultural University), College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. xuxiaoyun@mai

Published: October 2023


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Article Abstract

Mulberry pomace is rich in phytochemicals, but there are few studies on its utilization as a by-product. Natural foods containing phytochemicals can alleviate the toxic effects of excessive glucose intake. In this study, we investigated the protective effect of -fermented mulberry pomace extract (FMPE) under hyperglycemic conditions. The phenolic compounds and α-glucosidase inhibition of FMPE were determined using UPLC-MS and chemical models. Furthermore, was a model system to study the hypoglycemic effects. The results showed that the polyphenolics and α-glucosidase inhibition were improved during fermentation. Three phenolic components (cyanidin, 2,4,6-trihydroxybenzaldehyde, and taxifolin) were important variables for α-glucosidase inhibition. FMPE and the three key compound treatments reduced the glucose content and reactive oxygen species (ROS) level in . The protective mechanism occurred by activating DAF-16/FOXO and SKN-1/Nrf2. This study suggests that -fermentation was a potential way to utilize mulberry pomace polyphenols as hypoglycemic food ingredients.

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http://dx.doi.org/10.1039/d3fo02386aDOI Listing

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